Zobrazeno 1 - 10
of 153
pro vyhledávání: '"Bruce L, Goode"'
Publikováno v:
European Journal of Cell Biology, Vol 103, Iss 1, Pp 151378- (2024)
How cells tightly control the formation and turnover of branched actin filament arrays to drive cell motility, endocytosis, and other cellular processes is still not well understood. Here, we investigated the mechanistic relationship between two bind
Externí odkaz:
https://doaj.org/article/46b4fe7d6c094454834b49d284e88a33
Autor:
Biljana Ermanoska, Bob Asselbergh, Laura Morant, Maria-Luise Petrovic-Erfurth, Seyyedmohsen Hosseinibarkooie, Ricardo Leitão-Gonçalves, Leonardo Almeida-Souza, Sven Bervoets, Litao Sun, LaTasha Lee, Derek Atkinson, Akram Khanghahi, Ivaylo Tournev, Patrick Callaerts, Patrik Verstreken, Xiang-Lei Yang, Brunhilde Wirth, Avital A. Rodal, Vincent Timmerman, Bruce L. Goode, Tanja A. Godenschwege, Albena Jordanova
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Mutations in tRNA ligases, essential components of the translational machinery, are associated with Charcot-Marie-Tooth peripheral neuropathy, but the mechanistic details are not known. The authors report that the tyrosyl-tRNA synthetase is an evolut
Externí odkaz:
https://doaj.org/article/10366423a6464375b1b796d7bfb9bd6f
Publikováno v:
eLife, Vol 10 (2021)
How cells tune the size of their subcellular parts to scale with cell size is a fundamental question in cell biology. Until now, most studies on the size control of organelles and other subcellular structures have focused on scaling relationships wit
Externí odkaz:
https://doaj.org/article/d9936e74321242d6bcd0e8489a2d6095
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Cellular actin networks can be rapidly disassembled and remodeled in a few seconds, yet in vitro actin filaments depolymerize over minutes. Here the authors show that Cyclase-associated protein (CAP) and Cofilin synergize to processively depolymerize
Externí odkaz:
https://doaj.org/article/a85eeae229464d918654826b7dd93a43
Autor:
Thomas J. Rands, Bruce L. Goode
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Cell growth in budding yeast depends on rapid and on-going assembly and turnover of polarized actin cables, which direct intracellular transport of post-Golgi vesicles to the bud tip. Saccharomyces cerevisiae actin cables are polymerized by two formi
Externí odkaz:
https://doaj.org/article/2daeecd1791b49e8913a876635ef8e58
Autor:
Shashi Prakash Singh, Peter A Thomason, Sergio Lilla, Matthias Schaks, Qing Tang, Bruce L Goode, Laura M Machesky, Klemens Rottner, Robert H Insall
Publikováno v:
PLoS Biology, Vol 18, Iss 8, p e3000774 (2020)
The Scar/WAVE complex is the principal catalyst of pseudopod and lamellipod formation. Here we show that Scar/WAVE's proline-rich domain is polyphosphorylated after the complex is activated. Blocking Scar/WAVE activation stops phosphorylation in both
Externí odkaz:
https://doaj.org/article/bdfc9a7e62504de482bc8b2512da123b
Autor:
Niv Ierushalmi, Maya Malik-Garbi, Angelika Manhart, Enas Abu Shah, Bruce L Goode, Alex Mogilner, Kinneret Keren
Publikováno v:
eLife, Vol 9 (2020)
Centering and decentering of cellular components is essential for internal organization of cells and their ability to perform basic cellular functions such as division and motility. How cells achieve proper localization of their organelles is still n
Externí odkaz:
https://doaj.org/article/fe062294b29646aa939cb012c89993c5
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Abp1, a type II actin nucleation promoting factor, is a known component of branched actin networks but its mechanism remains poorly understood. Here, the authors find that Abp1 enhances Arp2/3-mediated actin branch formation, and blocks ‘debranchin
Externí odkaz:
https://doaj.org/article/461cdd4ab1814dbc9d5420598bd15668
Autor:
Kristie Wrasman, Salvatore L. Alioto, Yorke Zhang, Kyle Hoban, Marjon Khairy, Bruce L. Goode, Beverly Wendland
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 8, Iss 5, Pp 1497-1512 (2018)
Endocytosis is a fundamental process for internalizing material from the plasma membrane, including many transmembrane proteins that are selectively internalized depending on environmental conditions. In most cells, the main route of entry is clathri
Externí odkaz:
https://doaj.org/article/1ca224056b324714877d8f793bda030c
Autor:
Tommi Kotila, Konstantin Kogan, Giray Enkavi, Siyang Guo, Ilpo Vattulainen, Bruce L. Goode, Pekka Lappalainen
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Depolymerized ADP-actin monomers must be recharged with ATP for new rounds of filament assembly. Here the authors show that cyclase-associated protein (CAP) catalyzes actin nucleotide exchange in vivo and their CAP–actin complex structure reveals t
Externí odkaz:
https://doaj.org/article/0d7ef003bbce4a12bf5c7b11adc2fba6