Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Bruce K. BEYER"'
Autor:
Susan L. Makris, Bruce K. Beyer, Anthony DeLise, Amy L. Williams, Linda G. Roberts, Janet R. Hardy, Joshua F. Robinson, Marcia L. Feldkamp
Publikováno v:
Birth Defects Research. 115:797-800
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16e9b9f66d6bd64da3bf75fb67119c73
https://doi.org/10.1002/bdr2.2164
https://doi.org/10.1002/bdr2.2164
Autor:
Scott Engel, K. Turner, Marlowe J. Schneidkraut, Brian P. Enright, Karen Augustine-Rauch, Mary Ellen McNerney, Paul Barrow, S. Powlin, K. Brannen, Bruce K. Beyer, Michael J. Graziano, David Potter, William S. Nowland, Dinesh Stanislaus, Nicola Powles-Glover
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 124
An IQ DruSafe working group evaluated the concordance of 3 alternative teratogenicity assays (rat whole embryo culture, rWEC; zebrafish embryo culture, ZEC; and murine embryonic stem cells, mESC) with findings from rat or rabbit embryo-fetal developm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::822c740e5933ddf69fac1cc9f0f30b2c
https://pubmed.ncbi.nlm.nih.gov/34216694
https://pubmed.ncbi.nlm.nih.gov/34216694
Autor:
Julian M. French, Luc De Schaepdrijver, Connie L. Chen, Antong Chen, Daniel R. Minck, Andrew J McDougal, Howard M. Solomon, Belma Dogdas, Jonathan Helfgott, Vicki L. Sutherland, Xiaoyou Ying, Susan L. Makris, Lelia Scott, Zhou Chen, R. Mark Henkelman, Jane Stewart, Kok-Wah Hew, L. David Wise, Bruce K. Beyer, Gary W. Chmielewski, Oscar Bermudez, Hasan Alsaid, Sandra L. Wood, Arun K. Tatiparthi, Anthony M. DeLise, Alan M. Hoberman, Christopher T. Winkelmann, Jacob Hesterman, Wafa Harrouk, Cecilia W. Lo
Publikováno v:
Regulatory Toxicology and Pharmacology. 77:100-108
During the past two decades the use and refinements of imaging modalities have markedly increased making it possible to image embryos and fetuses used in pivotal nonclinical studies submitted to regulatory agencies. Implementing these technologies in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30e54101c62f0c9c23d1a1e4e3e7fc32
Autor:
Warren G. Foster, Bruce K. Beyer, Graeme J. Moffat, M. Desai, K. Chadwick, Jane Stewart, Brian P. Enright, William J. Breslin, L. De Schaepdrijver, Julia Y. Hui, L. Wiesner, K. Van Malderen, Belen Tornesi, Connie L. Chen
Publikováno v:
Therapeutic Innovation & Regulatory Science. 50:155-168
The Health and Environmental Sciences Institute (HESI) Developmental and Reproductive Toxicology Technical Committee sponsored a pharmaceutical industry survey on current industry practices for contraception use during clinical trials. The objectives
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fd1cbf0b8353b04160611ac9c4a2cb3
https://doi.org/10.1177/2168479015608415
https://doi.org/10.1177/2168479015608415
Autor:
Katie Turner, Julia Hui, Graeme J. Moffat, Dinesh Stanislaus, Bruce K. Beyer, Scott Engel, Kimberly Brannen, James Vergis, David Potter, Claudia McGinnis, Nicola Powles-Glover, Mary Ellen McNerney, Aaron Fullerton, Karen A. Augustine, Brian P. Enright, Paul Barrow, Michael J. Graziano, William S. Nowland, Marlowe J. Schneidkraut
Publikováno v:
Reproductive Toxicology. 88:17-18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e3c53e23ffa154d27a79ed315eec7ee
https://doi.org/10.1016/j.reprotox.2019.07.033
https://doi.org/10.1016/j.reprotox.2019.07.033
Autor:
Sonja Beken, Brian P. Enright, William J. Breslin, Jan Willem van der Laan, Christine L E Siezen, Gregg D. Cappon, Dinesh Stanislaus, Gerhard F. Weinbauer, Peter T. Theunissen, Jennifer E. Foreman, Connie L. Chen, Sandra L. Wood, Luc De Schaepdrijver, Gary W. Chmielewski, Aldert H. Piersma, Belen Tornesi, Jane Stewart, Kok-Wah Hew, Kary E. Thompson, Matthew T. Martin, Wafa Harrouk, Susan B. Laffan, Bruce K. Beyer, Alan M. Hoberman, Thomas B. Knudsen, Julia Y. Hui, Mary Ellen McNerney, Susan L. Makris
Publikováno v:
Critical reviews in toxicology. 46(10)
Regulatory non-clinical safety testing of human pharmaceuticals typically requires embryo-fetal developmental toxicity (EFDT) testing in two species (one rodent and one non-rodent). The question has been raised whether under some conditions EFDT test
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4707b0dd83d27eec8d13b127ccb7c29d
https://pubmed.ncbi.nlm.nih.gov/27848393
https://pubmed.ncbi.nlm.nih.gov/27848393
Autor:
Karen Davis-Bruno, Neil Chernoff, Wafa Harrouk, Gemma Janer, James H. Kim, Meredith S. Rocca, Ronald D. Hood, Anthony R. Scialli, John M. Rogers, Ulla Liminga, Bengt R. Danielsson, Bruce K. Beyer
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 92:36-51
Workshops on maternal toxicity were held at the annual Society of Toxicology, Teratology Society, and European Teratology Society meetings in 2009. Speakers presented background information prior to a general discussion on this topic. The following r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92d3c03ef9b9b2e565c370c5743e097e
https://doi.org/10.1002/bdrb.20281
https://doi.org/10.1002/bdrb.20281
Autor:
Geneviève Van Maele-Fabry, Phillip Mirkes, Bruce K. Beyer, Sidney Hunter, George P. Daston, Philippe Vanparys, Thomas J. Flynn, K. Sue O'Shea, Aldert H. Piersma, Robert E. Chapin, David Sandler, Richard H. Finnell, Karen Augustine-Rauch
Publikováno v:
Birth Defects Research. Part B: Developmental and Reproductive Toxicology, Vol. 83, no. 4, p. 446-456 (2008)
A meeting was convened so that users of three models for in vitro developmental toxicity (embryonic stem cells, whole embryo culture, and zebrafish) could share their experiences with each model, and explore the areas for improvement. We present a su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b895aa724880af51b38872d83e792ba0
https://doi.org/10.1002/bdrb.20158
https://doi.org/10.1002/bdrb.20158
Autor:
L. David WISE, Sidney L. BECK, Diana BELTRAME, Bruce K. BEYER, Ibrahim CHAHOUD, Robert L. CLARK, Ruth CLARK, Alice M. DRUGA, Maureen H. FEUSTON, Pierre GUITTIN, Susan M. HENWOOD, Carole A. KIMMEL, Pia LINDSTROM, Anthony K. PALMER, Judith A. PETRERE, Howard M. SOLOMON, Mineo YASUDA, Raymond G. YORK
Publikováno v:
Congenital Anomalies. 37:165-210
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75e831f6c799f097989e5b69a25c20a3
https://doi.org/10.1111/j.1741-4520.1997.tb00975.x
https://doi.org/10.1111/j.1741-4520.1997.tb00975.x
Autor:
Julia Y. Hui, Graham Bailey, Jane Stewart, Bruce K. Beyer, Graeme J. Moffat, William J. Breslin, Connie L. Chen, Anthony R. Scialli, Anthony M. DeLise, Kary E. Thompson, Ingrid Brück Bøgh
Publikováno v:
Reproductive toxicology (Elmsford, N.Y.). 59
Small molecule pharmaceutical products are assumed to reach concentrations in semen similar to those in blood plasma. Exposure modeling for these small-molecule products in humans assumes a daily dose of 5mL of semen and 100% absorption from the vagi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::523d950ef651e6d8e1f38a5b31600208
https://pubmed.ncbi.nlm.nih.gov/26854737
https://pubmed.ncbi.nlm.nih.gov/26854737