Zobrazeno 1 - 10
of 324
pro vyhledávání: '"Bruce K Cassels"'
Autor:
Thirumal Yempala, José Brea, María Isabel Loza, Douglas J. Matthies, Gerald Zapata-Torres, Bruce K. Cassels
Publikováno v:
ACS Omega, Vol 5, Iss 5, Pp 2260-2266 (2020)
Externí odkaz:
https://doaj.org/article/580e3768accb4d9ba7508b7456f331c1
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2020)
Amphetamine and its derivatives exhibit a wide range of pharmacological activities, including psychostimulant, hallucinogenic, entactogenic, anorectic, or antidepressant effects. The mechanisms of action underlying these effects are usually related t
Externí odkaz:
https://doaj.org/article/ef6b6595daed46abb5636c5cc7fd7695
Autor:
Alejandro Vásquez-Espinal, Osvaldo Yañez, Edison Osorio, Carlos Areche, Olimpo García-Beltrán, Lina María Ruiz, Bruce K. Cassels, William Tiznado
Publikováno v:
Frontiers in Chemistry, Vol 7 (2019)
It was recently shown that, when tested in cellular systems, quercetin oxidized products (Qox) have significantly better antioxidant activity than quercetin (Q) itself. The main Qox identified in the experiments are either 2,5,7,3′,4′-pentahydrox
Externí odkaz:
https://doaj.org/article/bb08d4f39aba493588382ad39b80446c
Autor:
Patricio Sáez-Briones, Vicente Castro-Castillo, Gabriela Díaz-Véliz, Luis Valladares, Rafael Barra, Alejandro Hernández, Bruce K. Cassels
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
The entactogen MDMA (3,4-methylenedioxy-methamphetamine, “Ecstasy”) exerts its psychotropic effects acting primarily as a substrate of the serotonin transporter (SERT) to induce a non-exocytotic release of serotonin. Nevertheless, the roles of sp
Externí odkaz:
https://doaj.org/article/0d49ae635a7247d2a84373f0d5b0c631
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0209804 (2019)
The last fifteen years have seen the emergence and overflow into the drug scene of "superpotent" N-benzylated phenethylamines belonging to the "NBOMe" series, accompanied by numerous research articles. Although N-benzyl substitution of 5-methoxytrypt
Externí odkaz:
https://doaj.org/article/9f4bcf336efd4288842c963454b21e34
Publikováno v:
Journal of Chemical Information and Modeling. 61:5001-5012
The binding of C-4-halogenated 1-(4-X-2,5-dimethoxyphenyl)-2-aminopropane (DOX) serotonin agonist psychedelics at all three 5-HT2 receptor subtypes is up to two orders of magnitude stronger for X = Cl, Br, or I (but not F) than when C-4 bears a hydro
Autor:
Edwin G. Pérez, Oriel A Sánchez-Velasco, Daniel A A Araya-Santelices, Jorge Saavedra-Olavarría, Patricio Hermosilla-Ibáñez, Bruce K. Cassels
Publikováno v:
Journal of Natural Products. 84:1985-1992
N-Arylcytisine derivatives are quite rare. We report here a practical methodology to obtain these compounds. Using the copper-catalyzed Chan-Lam coupling, we synthesized new N-arylcytisine derivatives at room temperature, in air and using inexpensive
Autor:
Olimpo García-Beltrán, Bruce K. Cassels, Claudio Pérez, Natalia Mena, Marco T. Núñez, Natalia P. Martínez, Paulina Pavez, Margarita E. Aliaga
Publikováno v:
Sensors, Vol 14, Iss 1, Pp 1358-1371 (2014)
Two new coumarin-based “turn-off” fluorescent probes, (E)-3-((3,4-dihydroxybenzylidene)amino)-7-hydroxy-2H-chromen-2-one (BS1) and (E)-3-((2,4-dihydroxybenzylidene)amino)-7-hydroxy-2H-chromen-2-one (BS2), were synthesized and their detection of c
Externí odkaz:
https://doaj.org/article/16965f69964a46bdb99809358921d1bf
Autor:
Osvaldo Yañez, Lina María Ruiz, Edison Osorio, Bruce K. Cassels, Carlos Areche, Olimpo García-Beltrán, Alejandro Vásquez-Espinal, William Tiznado
Publikováno v:
New Journal of Chemistry. 45:590-596
Previous experimental results on the free radical-scavenging properties of boldine, one of the most potent natural antioxidants, suggested that the benzylic hydrogen, neighboring a nitrogen lone electron pair, might be the key to its protective and a
Autor:
Douglas J Matthies, María Isabel Loza, José Brea, Bruce K. Cassels, Thirumal Yempala, Gerald Zapata-Torres
Publikováno v:
ACS Omega, Vol 5, Iss 5, Pp 2260-2266 (2020)
ACS Omega
ACS Omega
The human 5-HT2 receptor subtypes have high sequence identity in their orthosteric ligand-binding domain, and many agonists are poorly selective between the 5-HT2A and 5-HT2C subtypes. Nevertheless, their activation is associated with different pharm