Výsledky vyhledávání - "Bruce J. Walters"

Hypercapnia Alters Alveolar Epithelial Repair by a pH-Dependent and Adenylate Cyclase-Mediated Mechanism

Autor: Bruce J. Walters, Rolf D. Hubmayr, Blair Westerly, Randolph W. Stroetz, Shaohua Wang, Dante N. Schiavo, Richard A. Oeckler, Gustavo A. Cortes-Puentes

Publikováno v: Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)

Lung cell injury and repair is a hallmark of the acute respiratory distress syndrome (ARDS). Lung protective mechanical ventilation strategies in these patients may lead to hypercapnia (HC). Although HC has been explored in the clinical context of AR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77e17376848fafb0fe14fc2db337451d
https://doi.org/10.1038/s41598-018-36951-7

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Determinants of plasma membrane wounding by deforming stress

Autor: Won Yeon Lee, Othmar Kofler, Rolf D. Hubmayr, Richard A. Oeckler, Bruce J. Walters, Randolph W. Stroetz, Mun-Gi Park, Deborah L. Rasmussen, Heung-Bum Lee, Hewan A. Belete

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 299:L826-L833

Once excess liquid gains access to air spaces of an injured lung, the act of breathing creates and destroys foam and thereby contributes to the wounding of epithelial cells by interfacial stress. Since cells are not elastic continua, but rather compl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e0ea4f31ce98088e44fffa94d77a294
https://doi.org/10.1152/ajplung.00217.2010

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Validation of a new live cell strain system: characterization of plasma membrane stress failure

Autor: Nicholas E. Vlahakis, Rolf D. Hubmayr, Mark A. Schroeder, Bruce J. Walters, Randolph W. Stroetz

Publikováno v: Journal of Applied Physiology. 90:2361-2370

Motivated by our interest in lung deformation injury, we report on the validation of a new live cell strain system. We showed that the system maintains a cell culture environment equivalent to that provided by conventional incubators and that its str

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dd677e0d601c65c4487d442c489a4f1
https://doi.org/10.1152/jappl.2001.90.6.2361

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Mechanisms of recruitment in oleic acid-injured lungs

Autor: Rolf D. Hubmayr, Marek A. Martynowicz, Bruce J. Walters

Publikováno v: Journal of Applied Physiology. 90:1744-1753

Lung recruitment strategies, such as the application of positive end-expiratory pressure (PEEP), are thought to protect the lungs from ventilator-associated injury by reducing the shear stress associated with the repeated opening of collapsed periphe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ea69b928d4192e37d0c886792ab0b3f
https://doi.org/10.1152/jappl.2001.90.5.1744

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Regional Expansion of Oleic Acid–Injured Lungs

Autor: Rolf D. Hubmayr, Thomas A. Minor, Bruce J. Walters, Marek A. Martynowicz

Publikováno v: American Journal of Respiratory and Critical Care Medicine. 160:250-258

It has been suggested that dependent regions of an injured lung are collapsed and subject to cyclic reopening and collapse during mechanical ventilation. To test this hypothesis, we measured both temporal and spatial heterogeneity of lobar expansion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb57527c9a2416958bb03fd8f0ed5d25
https://doi.org/10.1164/ajrccm.160.1.9808101

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Biophysical determinants of alveolar epithelial plasma membrane wounding associated with mechanical ventilation

Autor: Paul A Valencia, Deborah McCall, Rolf D. Hubmayr, Randolph W. Stroetz, Omar Hussein, Bruce J. Walters

Mechanical ventilation may cause harm by straining lungs at a time they are particularly prone to injury from deforming stress. The objective of this study was to define the relative contributions of alveolar overdistension and cyclic recruitment and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90c1e5da8c50decee6869eeae42c4ba6
https://europepmc.org/articles/PMC3798764/

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