Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Bruce J. Shenker"'
Autor:
Kathleen Boesze-Battaglia, Gary H. Cohen, Paul F. Bates, Lisa M. Walker, Ali Zekavat, Bruce J. Shenker
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt) is capable of intoxicating lymphocytes macrophages, mast cells and epithelial cells. Following Cdt binding to cholesterol, in the region of membrane lipid rafts, the CdtB and Cdt
Externí odkaz:
https://doaj.org/article/b4dc70dc12ab4fc7a84cf22c58d7d983
Autor:
Taewan J. Kim, Andrew S. MacElroy, Aleena Defreitas, Bruce J. Shenker, Kathleen Boesze-Battaglia
Publikováno v:
Dentistry Journal, Vol 12, Iss 7, p 195 (2024)
Our research explores the interplay between Aggregatibacter actinomycetemcomitans (Aa) cytolethal distending toxin (Cdt) and the host’s inflammatory response in molar/incisor pattern periodontitis (MIPP). Cdt disrupts phosphatidylinositol-3,4,5-tri
Externí odkaz:
https://doaj.org/article/fd3a1330b6eb47aaa0e0053caa415461
Autor:
Bruce J. Shenker, Jonathan Korostoff, Lisa P. Walker, Ali Zekavat, Anuradha Dhingra, Taewan J. Kim, Kathleen Boesze-Battaglia
Publikováno v:
Pathogens, Vol 13, Iss 2, p 155 (2024)
Recently, we reported that oral-epithelial cells (OE) are unique in their response to Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt) in that cell cycle arrest (G2/M) occurs without leading to apoptosis. We now demonstrate tha
Externí odkaz:
https://doaj.org/article/7799e2ad0c1347709122d6bd5c5466d2
Autor:
Taewan J. Kim, Bruce J. Shenker, Andrew S. MacElroy, Samuel Spradlin, Lisa P. Walker, Kathleen Boesze-Battaglia
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
Externí odkaz:
https://doaj.org/article/aa27ab89a8224aadbd65d695a0662335
Aggregatibacter actinomycetemcomitans cytolethal distending toxin modulates host phagocytic function
Autor:
Taewan J. Kim, Bruce J. Shenker, Andrew S. MacElroy, Samuel Spradlin, Lisa P. Walker, Kathleen Boesze-Battaglia
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
Cytolethal distending toxins (Cdt) are a family of toxins produced by several human pathogens which infect mucocutaneous tissue and induce inflammatory disease. Human macrophages exposed to Aggregatibacter actinomycetemcomitans (Aa) Cdt respond throu
Externí odkaz:
https://doaj.org/article/a1aa02214b6a4f7587258791a41c72ad
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 19, p 11831 (2022)
Cytolethal distending toxins (Cdt) are produced by a diverse group of pathogens. One Cdt-producing organism, Aggregatibacter actinomycetemcomitans, plays a critical role in the pathogenesis of a unique form of periodontitis, formerly referred to as l
Externí odkaz:
https://doaj.org/article/eef89bd6761a44eb979869fd4378eefa
Autor:
Grace Huang, Kathleen Boesze-Battaglia, Lisa P. Walker, Ali Zekavat, Zachary P. Schaefer, Steven R. Blanke, Bruce J. Shenker
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Human lymphocytes exposed to Aggregatibacter actinomycetemcomitans (Aa) cytolethal distending toxin (Cdt) undergo cell cycle arrest and apoptosis. In previous studies, we demonstrated that the active Cdt subunit, CdtB, is a potent phosphatidylinosito
Externí odkaz:
https://doaj.org/article/95d2a77b939d4cecaecc0d9e6e8b8f61
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt) is a heterotrimeric AB2 toxin capable of inducing cell cycle arrest and apoptosis in lymphocytes and other cell types. Recently, we have demonstrated that human macrophages a
Externí odkaz:
https://doaj.org/article/4d9d2cc42db644e699d718e19f76c35c
Publikováno v:
Pathogens, Vol 9, Iss 1, p 38 (2020)
The Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt) induces lymphocytes to undergo cell-cycle arrest and apoptosis; toxicity is dependent upon the active Cdt subunit, CdtB. We now demonstrate that p21CIP1/WAF1 is critical to C
Externí odkaz:
https://doaj.org/article/1a5fa09864d64d578ba997e1383b1db0
Autor:
Kathleen Boesze-Battaglia, Lisa P. Walker, Anuradha Dhingra, Konstantin Kandror, Hsin-Yao Tang, Bruce J. Shenker
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 7 (2017)
The Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt) is a heterotrimeric AB2 toxin capable of inducing lymphocytes, and other cell types, to undergo cell cycle arrest and apoptosis. Exposure to Cdt results in binding to the cel
Externí odkaz:
https://doaj.org/article/74da68f545e4450d9e22a0fe59218277