Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Bruce J. Dolnick"'
Autor:
Qi Wu, Bruce J. Dolnick
Publikováno v:
Molecular Pharmacology. 63:167-173
Thymidylate synthase (TS), a key cancer chemotherapeutic target, catalyzes the conversion of deoxyuridylate to thymidylate. TS can serve as a repressor of its own synthesis by binding to its own mRNA through TS-specific binding elements (TBEs). In th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::461966e378efc7ee472a56f072987e08
https://doi.org/10.1124/mol.63.1.167
https://doi.org/10.1124/mol.63.1.167
Autor:
Bruce J. Dolnick
Publikováno v:
Pharmacology & Therapeutics. 75:179-184
Within the last few years a number of mammalian genes have been found for which there exist naturally occurring "antisense" RNA species with complementarity to mRNAs. Effects of antisense RNA on "sense" RNA have yet to be established. Nevertheless, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba816878d7cccd73fddc794e2a5e4b62
https://doi.org/10.1016/s0163-7258(97)00050-8
https://doi.org/10.1016/s0163-7258(97)00050-8
Publikováno v:
Tetrahedron Letters. 35:3029-3032
A simplified method has been developed for the synthesis of acridine and/or lipid containing oligodeoxynucleotides using a commercially available resin and reagents.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98d079aebcdaa4c265ee2d11ba379f61
https://doi.org/10.1016/s0040-4039(00)76819-5
https://doi.org/10.1016/s0040-4039(00)76819-5
Autor:
Sijian Wang, Bruce J. Dolnick
Publikováno v:
Nucleic Acids Research. 21:4383-4391
Previous studies have demonstrated that for an antisense RNA to be effective in attenuating gene expression, a large but indeterminate excess of antisense RNA is required. To quantitatively evaluate RNA hybrid duplex formation, expression vectors con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20cddeea4947fdfcb07563e660ea6ba0
https://doi.org/10.1093/nar/21.18.4383
https://doi.org/10.1093/nar/21.18.4383
Autor:
Bruce J. Dolnick
Publikováno v:
Nucleic Acids Research. 21:1747-1752
Based upon reverse transcription and polymerase chain reaction results with human KB cell RNA, a cDNA (i.e., 3'rTS1, 1557 nt) with complementarity to thymidylate synthase mRNA was cloned and sequenced. Northern blot analysis showed that 3'rTS1 corres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f255a9f3bb974b6fff1c44b91ee3152
https://doi.org/10.1093/nar/21.8.1747
https://doi.org/10.1093/nar/21.8.1747
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fff586ad2e0b20f09a2bede6e1837b00
https://doi.org/10.1002/chin.199437246
https://doi.org/10.1002/chin.199437246
Autor:
Bruce J. Dolnick
Publikováno v:
Cancer Investigation. 9:185-194
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68d6254341e9e22353558b81e3f7636f
https://doi.org/10.3109/07357909109044229
https://doi.org/10.3109/07357909109044229
Publikováno v:
BMC Genomics, Vol 6, Iss 1, p 125 (2005)
BMC Genomics
BMC Genomics
Background The rTS gene (ENOSF1), first identified in Homo sapiens as a gene complementary to the thymidylate synthase (TYMS) mRNA, is known to encode two protein isoforms, rTSα and rTSβ. The rTSβ isoform appears to be an enzyme responsible for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5109f4d2f6d9e9487e03c53b709bd076
https://doi.org/10.1186/1471-2164-6-125
https://doi.org/10.1186/1471-2164-6-125
Autor:
Norman J. Angelino, Kuan-Chih Chow, Qi Wu, Bruce J. Dolnick, Ree Y. Dolnick, Lawrence V. Stephanie, Janice R. Sufrin
Publikováno v:
Cancer research. 65(13)
The rTSβ protein has been hypothesized to synthesize signaling molecules that can down-regulate thymidylate synthase. These molecules share biological and chemical properties with acyl-homoserine lactones (AHL), suggesting some AHLs might act as rTS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a0ecf2a8792a820a8f5646d271d30fd
https://pubmed.ncbi.nlm.nih.gov/15994970
https://pubmed.ncbi.nlm.nih.gov/15994970
Autor:
Bruce J. Dolnick
Publikováno v:
Clinical colorectal cancer. 5(1)
The rTS gene was discovered because it codes for a complementary (antisense) RNA to the messenger RNA for thymidylate synthase (TS). It was later shown that rTS also encodes 2 proteins, rTSα and rTβ. Recently, it has become apparent that rTβ overe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74baa9008a65371a8fe0f36203470b9f
https://pubmed.ncbi.nlm.nih.gov/15929801
https://pubmed.ncbi.nlm.nih.gov/15929801