Zobrazeno 1 - 10
of 434
pro vyhledávání: '"Bruce J Brew"'
Autor:
Sarah J Byrnes, Kathleen Busman-Sahay, Thomas A Angelovich, Skyler Younger, Sol Taylor-Brill, Michael Nekorchuk, Stephen Bondoc, Rachel Dannay, Margaret Terry, Catherine R Cochrane, Trisha A Jenkins, Michael Roche, Claire Deleage, Steven E Bosinger, Mirko Paiardini, Bruce J Brew, Jacob D Estes, Melissa J Churchill
Publikováno v:
PLoS Pathogens, Vol 19, Iss 3, p e1011290 (2023)
HIV-associated neurocognitive disorders (HAND) affect ~40% of virally suppressed people with HIV (PWH), however, the precise viral dependent and independent changes to the brain are unclear. Here we characterized the CNS reservoir and immune environm
Externí odkaz:
https://doaj.org/article/a8b2d780e7df44039d495cd700b5e282
Publikováno v:
BMJ Neurology Open, Vol 3, Iss Suppl 1 (2021)
Externí odkaz:
https://doaj.org/article/41b240c0c27a44f3ac54dc53f4b11313
Autor:
Anthony Byrne, Gail Matthews, Bruce J Brew, Lucette A Cysique, Yasmin Allen-Davidian, David R Darley, Greg Dore
Publikováno v:
BMJ Neurology Open, Vol 3, Iss Suppl 1 (2021)
Externí odkaz:
https://doaj.org/article/7070249bd5084ec580a6940cd6de286c
Publikováno v:
BMJ Neurology Open, Vol 3, Iss Suppl 1 (2021)
Externí odkaz:
https://doaj.org/article/d6906de16ddb490bab4523bece82060d
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0171887 (2017)
BACKGROUND:The longitudinal rate and profile of cognitive decline in persons with stable, treated, and virally suppressed HIV infection is not established. To address this question, the current study quantifies the rate of cognitive decline in a coho
Externí odkaz:
https://doaj.org/article/dca0930e6f0a47c0800bdd87263dd541
Autor:
Lucette A Cysique, William J Hey-Cunningham, Nadene Dermody, Phillip Chan, Bruce J Brew, Kersten K Koelsch
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0120488 (2015)
To determine the contribution of peripheral blood mononuclear cells' (PBMCs) HIV DNA levels to HIV-associated dementia (HAD) and non-demented HIV-associated neurocognitive disorders (HAND) in chronically HIV-infected adults with long-term viral suppr
Externí odkaz:
https://doaj.org/article/3c23e3ef850f485b969f2046522e5cd1
Autor:
Simon P Jones, Nunzio F Franco, Bianca Varney, Gayathri Sundaram, David A Brown, Josien de Bie, Chai K Lim, Gilles J Guillemin, Bruce J Brew
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0131389 (2015)
The kynurenine pathway is a fundamental mechanism of immunosuppression and peripheral tolerance. It is increasingly recognized as playing a major role in the pathogenesis of a wide variety of inflammatory, neurodegenerative and malignant disorders. H
Externí odkaz:
https://doaj.org/article/f976ecbfb19b491faa069a1c68450bee
Autor:
Seray Adams, Charles Teo, Kerrie L McDonald, Anna Zinger, Sonia Bustamante, Chai K Lim, Gayathri Sundaram, Nady Braidy, Bruce J Brew, Gilles J Guillemin
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112945 (2014)
The kynurenine pathway (KP) is the principal route of L-tryptophan (TRP) catabolism leading to the production of kynurenine (KYN), the neuroprotectants, kynurenic acid (KYNA) and picolinic acid (PIC), the excitotoxin, quinolinic acid (QUIN) and the e
Externí odkaz:
https://doaj.org/article/a0200add04b44100ad43f6621c4156d7
Autor:
Wei Wu, Joseph A Nicolazzo, Li Wen, Roger Chung, Roger Stankovic, Shisan S Bao, Chai K Lim, Bruce J Brew, Karen M Cullen, Gilles J Guillemin
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e59749 (2013)
To assess the role of the kynurenine pathway in the pathology of Alzheimer's disease (AD), the expression and localization of key components of the kynurenine pathway including the key regulatory enzyme tryptophan 2,3 dioxygenase (TDO), and the metab
Externí odkaz:
https://doaj.org/article/c69cbd3ce9a345eab273769269126948
Autor:
Lucette A Cysique, Kirsten Moffat, Danielle M Moore, Tammy A Lane, Nicholas W S Davies, Andrew Carr, Bruce J Brew, Caroline Rae
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61738 (2013)
BackgroundCardiovascular disease (CVD) and premature aging have been hypothesized as new risk factors for HIV associated neurocognitive disorders (HAND) in adults with virally-suppressed HIV infection. Moreover, their significance and relation to mor
Externí odkaz:
https://doaj.org/article/d8c71e65fc344b9fa17ea9c6d2eebbd5