Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Bruce Hacker"'
Autor:
Yunik Chang, Bruce Hacker
Publikováno v:
Journal of Pharmaceutical Sciences. 71:328-331
N 6 -(△ 2 -Isopentenyl)adenosine (I), a nucleoside previously shown to be cytotoxic against several types of tumor cells, was impregnated in silicone polymer monolithic disc devices for release in vitro against lymphocytic mouse leukemia cells. Plo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eb684f82b432889b5d1ed04c5da7fef
https://doi.org/10.1002/jps.2600710317
https://doi.org/10.1002/jps.2600710317
Autor:
Yunik Changx, Bruce Hacker
Publikováno v:
Journal of Pharmaceutical Sciences. 72:902-905
□ The adenosine deaminase inhibitor pentostatin (I), recently shown to be effective in the treatment of several types of acute and chronic human leukemias, was impregnated in a silicone polymer monolithic disk device for release in vitro in the pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5884c1e911a3701b51bc45f64ba1effc
https://doi.org/10.1002/jps.2600720815
https://doi.org/10.1002/jps.2600720815
Publikováno v:
Cryobiology. 12:463-479
Cultured L1210 lymphocytic leukemic cells resistant to cytosine arabinoside or Cytoxan were frozen under different conditions for up to 5 months and transplanted into recipient mice. Biochemical determinations including DNA, total RNA and drug resist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61fe779eb341f8b17a51123e2e4a124f
https://doi.org/10.1016/0011-2240(75)90028-0
https://doi.org/10.1016/0011-2240(75)90028-0
Autor:
Thomas L. Feldbush, Bruce Hacker
Publikováno v:
Biochemical Pharmacology. 18:847-853
The nucleoside, N 6 -( Δ 2 - iso pentenyl)adenosine (iPA), shown to be an integral constituent of certain transfer RNA's, has been found to inhibit the incorporation of uridine into RNA and thymidine into DNA. This assay in vitro , which uses phytoh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f285276eae2364762a6c7cb5749ef49
https://doi.org/10.1016/0006-2952(69)90055-0
https://doi.org/10.1016/0006-2952(69)90055-0
Publikováno v:
Biochemical Journal. 126:1057-1066
Methods were devised for the assay of tRNA methylases of rat bone. The activities of bone tRNA methylases are similar to those from other mammalian tissues. However, unlike reports on liver methylases, no inhibitors were found in the supernatant frac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c3186ded99b4b57a629a156b2171cc6
https://doi.org/10.1042/bj1261057a
https://doi.org/10.1042/bj1261057a
Autor:
Bruce Hacker, T. L. Feldbush
Publikováno v:
Cancer. 27:1384-1387
N6-(δ2-isopentenyl) adenosine (iPA) has been previously shown to inhibit DNA and RNA synthesis in cultured lymphocytes and to suppress antibody formation in vivo. The effects have been extended to show that iPA has little preferential action on phyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a1ddbc01daf70dd8d96ca69ff6d12cf
https://doi.org/10.1002/1097-0142(197106)27:6<1384::aid-cncr2820270618>3.0.co
https://doi.org/10.1002/1097-0142(197106)27:6<1384::aid-cncr2820270618>3.0.co
Publikováno v:
The Journal of Immunology. 108:1726-1728
Recent reports have dealt with the demonstration of specific antibodies found in response to immunization of rabbits with conjugates of methylated nucleoside haptens (1, 2). Not surprising were the findings that the methyl group and its position on t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::947124a0d17f3a75eceb0f2ae7aa5e7c
https://doi.org/10.4049/jimmunol.108.6.1726
https://doi.org/10.4049/jimmunol.108.6.1726
Autor:
Bruce Hacker, Yunik Chang
Publikováno v:
Journal of pharmaceutical sciences. 72(10)
Pentostatin (I), a tight-binding inhibitor of adenosine deaminase, was evaluated in combination with the partially effective antitumor nucleoside N6-(delta 2-isopentenyl)adenosine (II) for cytotoxic activity against cultured L-1210 lymphocytic mouse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97248f195530ca2a9c1d8d6d966671bb
https://pubmed.ncbi.nlm.nih.gov/6606032
https://pubmed.ncbi.nlm.nih.gov/6606032
Publikováno v:
Annals of the New York Academy of Sciences. 390
Electrophoresis and ion-exchange column chromatography were used to separate the wide varieties of acid phosphatases with different biological and clinical significance. Band 0 was very strong in ascitic cells with many autophagic vacuoles, indicatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff0881a9b492632f797fb813d5c1b80b
https://pubmed.ncbi.nlm.nih.gov/6953921
https://pubmed.ncbi.nlm.nih.gov/6953921
Autor:
Bruce Hacker, Philip J. Medon
Publikováno v:
Journal of pharmaceutical sciences. 73(2)
The use of the aqueous extracts of Eleutherococcus senticosus in combination with either cytarabine or N6-(delta 2-isopentenyl)-adenosine gave additive antiproliferative effects against L1210 murine leukemia. The ED50 for E. senticosus root extracts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85a2b1a97a2323447320c9c2a94d5647
https://pubmed.ncbi.nlm.nih.gov/6707901
https://pubmed.ncbi.nlm.nih.gov/6707901