Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Bruce H. McCosar"'
Publikováno v:
ARKIVOC, Vol 2005, Iss 10, Pp 285-291 (2005)
Externí odkaz:
https://doaj.org/article/9a22fa08886941db9940b503a158d3e4
Autor:
Lianhao Zhang, Ralf Mueller, Michael E. Pape, Andrew McKee, Eelco J. Ebbers, Charles L. Bisgaier, Bruce H. McCosar, Jean-Louis H Dasseux, Clay T. Cramer, Dennis Smith, Mike Relou, Henk Regeling, Emil Pop, B.R. Krause, Frank M. C. Leemhuis, Roel P.L. Bell, Dennis Verdijk, Brian Goetz, Daniela Carmen Oniciu
Publikováno v:
Synthetic Communications. 36:365-391
A series of pantolactone and pantothenic acid derivatives (1–10) were synthesized to be tested for their potential as lipid regulating agents that act as Coenzyme‐A mimics. The syntheses were performed with moderate to high yields.
Autor:
Daniela C. Oniciu, Sergey Denisenko, Ralf Mueller, Charles L Bisgaier, Krista L Hopson, Bruce H McCosar, Tian-Bao Huang, Lian Hao Zhang, Brian Goetz, Caiming Duan, Jing Yang, Clay T Cramer, Catherine Delaney Freiman, Jean-Louis H Dasseux, Otto J Geoffroy, Michael E Pape, Emil Pop
Publikováno v:
Journal of Medicinal Chemistry. 47:6082-6099
Keto-substituted hydrocarbons with 11-19 methylene and bis-terminal hydroxyl and carboxyl groups have been synthesized and evaluated in both in vivo and in vitro assays for their potential to favorably alter lipid disorders including metabolic syndro
Publikováno v:
Tetrahedron: Asymmetry. 10:4285-4294
The synthesis and application of the chiral reagents (R)- and (S)-N-(benzyloxycarbonyl)-3,4-epoxybutylamine is described for the first time. These 4-amino-2-hydroxybutyl synthons are successfully employed in the assembly of two hydroxylated triamines
Autor:
Richard E. Smith, Raymond J. Bergeron, William R. Weimar, Gary M. Brittenham, Jan Wiegand, Bruce H. McCosar, James S. McManis
Publikováno v:
Journal of Medicinal Chemistry. 42:2432-2440
Additional structure-activity studies of desferrithiocin analogues are carried out. The effects of stereochemistry at C-4 on the ligands' iron clearing efficiency are reviewed and assessed using the enantiomers 4,5-dihydro-2-(2, 4-dihydroxyphenyl)thi
Autor:
Ralf Müller, Bruce H. McCosar, Raymond J. Bergeron, Richard E. Smith, Hua Yao, Curt O. Zimmerman, William R. Weimar
Publikováno v:
Journal of Medicinal Chemistry. 41:3888-3900
Two new synthetic methods which allow access to (2S)-deoxyhypusine, natural (2S,9R)-hypusine, (2S,9S)-hypusine, and deoxyhypusine- and hypusine-containing peptides are described. The methods involve both the construction of a deoxyhypusine reagent in
Autor:
Bruce H. McCosar, Kirk S. Schanze
Publikováno v:
Inorganic Chemistry. 35:6800-6808
The photophysics and photochemistry of the salt [(bpy)Re(CO)(3)(py)(+)][BzBPh(3)(-)] (ReBo, where bpy = 2,2'-bipyridine, py = pyridine, Bz = C(6)H(5)CH(2) and Ph = C(6)H(5)) has been investigated in THF and CH(3)CN solutions. UV-visible absorption an
Publikováno v:
ChemInform. 31
Autor:
Raymond J. Bergeron, Hua Yao, Curt O. Zimmerman, Ralf Müller, William R. Weimar, Bruce H. McCosar, Richard E. Smith
Publikováno v:
Journal of medicinal chemistry. 41(20)
The availability of synthetic hypusine and deoxyhypusine has made it possible to develop analytical methods which allow for the measurement of these compounds in various tissues. The methods involve dansylation of extracts from the pellet remaining a