Zobrazeno 1 - 10
of 673
pro vyhledávání: '"Bruce H. Lipshutz"'
Publikováno v:
JACS Au, Vol 4, Iss 2, Pp 680-689 (2024)
Externí odkaz:
https://doaj.org/article/95ff415ee5714db1a6fd1de5f23529de
Autor:
Joseph R. A. Kincaid, Juan C. Caravez, Karthik S. Iyer, Rahul D. Kavthe, Nico Fleck, Donald H. Aue, Bruce H. Lipshutz
Publikováno v:
Communications Chemistry, Vol 5, Iss 1, Pp 1-7 (2022)
The antiviral drug nirmatrelvir is the active ingredient in Paxlovid, a SARS-CoV-2 Mpro inhibitor developed by Pfizer, however, its synthetic procedure faces limitations for meeting urgent demand. Here, the authors optimize the key synthetic steps an
Externí odkaz:
https://doaj.org/article/c6511b695b1d4b759ca58f72f163042a
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 691-737 (2020)
Numerous reactions generating C–Si and C–B bonds are in focus owing to the importance of incorporating silicon or boron into new or existing drugs, in addition to their use as building blocks in cross-coupling reactions en route to various target
Externí odkaz:
https://doaj.org/article/dbd295871c714aa788edf2bb0163339b
Autor:
Margery Cortes-Clerget, Nnamdi Akporji, Jianguang Zhou, Feng Gao, Pengfei Guo, Michael Parmentier, Fabrice Gallou, Jean-Yves Berthon, Bruce H. Lipshutz
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Chemo-enzymatic tandem processes allow access to more complex non-racemic products. Here, the authors show that non-ionic surfactants, especially the tailor-made surfactant TPGS-750-M, enhance the activity of alcohol dehydrogenase to afford stereopur
Externí odkaz:
https://doaj.org/article/2324756d621441b68c4e51ade06bad80
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 12, Iss 1, Pp 1040-1064 (2016)
Cationic palladium(II) complexes have been found to be highly reactive towards aromatic C–H activation of arylureas at room temperature. A commercially available catalyst [Pd(MeCN)4](BF4)2 or a nitrile-free cationic palladium(II) complex generated
Externí odkaz:
https://doaj.org/article/2e3539d08dbd431083e70a9a8cbe76d4
Autor:
Joseph R. A. Kincaid, Madison J. Wong, Nnamdi Akporji, Fabrice Gallou, David M. Fialho, Bruce H. Lipshutz
Publikováno v:
Journal of the American Chemical Society. 145:4266-4278
Autor:
Kaitlyn M. Freiberg, Rahul D. Kavthe, Rohan M. Thomas, David M. Fialho, Paris Dee, Matthew Scurria, Bruce H. Lipshutz
Publikováno v:
Chemical science, vol 14, iss 13
Technology for generating especially important amide and peptide bonds from carboxylic acids and amines that avoids traditional coupling reagents is described. The 1-pot processes developed rely on thioester formation, neat, using a simple dithiocarb
Publikováno v:
Green Chemistry. 25:2663-2671
Facile reductions of carboxylic acids to aldehydes or alcohols can be effected under mild conditions upon initial conversion to their corresponding S-2-pyridyl thioesters.
Publikováno v:
Organic Letters. 24:9049-9053
Autor:
Volker Berl, Yasmin L. Hurd, Bruce H. Lipshutz, Markus Roggen, Eric J. Mathur, Malkanthi Evans
Publikováno v:
Cannabis and Cannabinoid Research. 7:777-789