Výsledky vyhledávání - "Bruce H. Lipshutz"

Copper: Organometallic ChemistryBased in part on the article Copper: Organometallic Chemistry by Bruce H. Lipshutz & Michael R. Wood which appeared in theEncyclopedia of Inorganic Chemistry, First Edition

Autor: Steven S. Pfeiffer, Bruce H. Lipshutz

Publikováno v: Encyclopedia of Inorganic and Bioinorganic Chemistry

Much of copper chemistry over the past decade has transitioned toward catalysis, driven in large measure by environmental rather than economic concerns. Catalytic processes have appeared in large numbers, in particular due to the advances made in bot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb2ba5dd570e6f49589d98ba01f1ab16
https://doi.org/10.1002/0470862106.ia053

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Akademický článek

A sustainable synthesis of the SARS-CoV-2 Mpro inhibitor nirmatrelvir, the active ingredient in Paxlovid

Autor: Joseph R. A. Kincaid, Juan C. Caravez, Karthik S. Iyer, Rahul D. Kavthe, Nico Fleck, Donald H. Aue, Bruce H. Lipshutz

Publikováno v: Communications Chemistry, Vol 5, Iss 1, Pp 1-7 (2022)

The antiviral drug nirmatrelvir is the active ingredient in Paxlovid, a SARS-CoV-2 Mpro inhibitor developed by Pfizer, however, its synthetic procedure faces limitations for meeting urgent demand. Here, the authors optimize the key synthetic steps an

Externí odkaz: https://doaj.org/article/c6511b695b1d4b759ca58f72f163042a

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Akademický článek

Recent advances in Cu-catalyzed C(sp3)–Si and C(sp3)–B bond formation

Autor: Balaram S. Takale, Ruchita R. Thakore, Elham Etemadi-Davan, Bruce H. Lipshutz

Publikováno v: Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 691-737 (2020)

Numerous reactions generating C–Si and C–B bonds are in focus owing to the importance of incorporating silicon or boron into new or existing drugs, in addition to their use as building blocks in cross-coupling reactions en route to various target

Externí odkaz: https://doaj.org/article/dbd295871c714aa788edf2bb0163339b

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Akademický článek

Bridging the gap between transition metal- and bio-catalysis via aqueous micellar catalysis

Autor: Margery Cortes-Clerget, Nnamdi Akporji, Jianguang Zhou, Feng Gao, Pengfei Guo, Michael Parmentier, Fabrice Gallou, Jean-Yves Berthon, Bruce H. Lipshutz

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)

Chemo-enzymatic tandem processes allow access to more complex non-racemic products. Here, the authors show that non-ionic surfactants, especially the tailor-made surfactant TPGS-750-M, enhance the activity of alcohol dehydrogenase to afford stereopur

Externí odkaz: https://doaj.org/article/2324756d621441b68c4e51ade06bad80

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Direct formation of amide/peptide bonds from carboxylic acids: no traditional coupling reagents, 1-pot, and green

Autor: Kaitlyn M. Freiberg, Rahul D. Kavthe, Rohan M. Thomas, David M. Fialho, Paris Dee, Matthew Scurria, Bruce H. Lipshutz

Publikováno v: Chemical science, vol 14, iss 13

Technology for generating especially important amide and peptide bonds from carboxylic acids and amines that avoids traditional coupling reagents is described. The 1-pot processes developed rely on thioester formation, neat, using a simple dithiocarb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6114c7d020cc41dc9aa7277b86d29344
https://doi.org/10.1039/d3sc00198a

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Facile, green, and functional group-tolerant reductions of carboxylic acids…in, or with, water

Autor: Karthik S. Iyer, Chandler Nelson, Bruce H. Lipshutz

Publikováno v: Green Chemistry. 25:2663-2671

Facile reductions of carboxylic acids to aldehydes or alcohols can be effected under mild conditions upon initial conversion to their corresponding S-2-pyridyl thioesters.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::17978458a10bfd5b2a89117f3b6e5508
https://doi.org/10.1039/d3gc00517h

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