Skin autofluorescence and cause-specific mortality in a population-based cohort

Autor: Henderikus E. Boersma, Andries J. Smit, Andrew D. Paterson, Bruce H. R. Wolffenbuttel, Melanie M. van der Klauw

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)

Abstract We aimed to assess the association of SAF with cardiovascular mortality in the general population and the possible association between SAF with other disease-specific mortality rates. We evaluated 77,143 participants without known diabetes o

Externí odkaz: https://doaj.org/article/9277188a07fe497885577f11697d8288

Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications

Autor: Rosalie B. T. M. Sterenborg, Inga Steinbrenner, Yong Li, Melissa N. Bujnis, Tatsuhiko Naito, Eirini Marouli, Tessel E. Galesloot, Oladapo Babajide, Laura Andreasen, Arne Astrup, Bjørn Olav Åsvold, Stefania Bandinelli, Marian Beekman, John P. Beilby, Jette Bork-Jensen, Thibaud Boutin, Jennifer A. Brody, Suzanne J. Brown, Ben Brumpton, Purdey J. Campbell, Anne R. Cappola, Graziano Ceresini, Layal Chaker, Daniel I. Chasman, Maria Pina Concas, Rodrigo Coutinho de Almeida, Simone M. Cross, Francesco Cucca, Ian J. Deary, Alisa Devedzic Kjaergaard, Justin B. Echouffo Tcheugui, Christina Ellervik, Johan G. Eriksson, Luigi Ferrucci, Jan Freudenberg, GHS DiscovEHR, Regeneron Genetics Center, Christian Fuchsberger, Christian Gieger, Franco Giulianini, Martin Gögele, Sarah E. Graham, Niels Grarup, Ivana Gunjača, Torben Hansen, Barbara N. Harding, Sarah E. Harris, Stig Haunsø, Caroline Hayward, Jennie Hui, Till Ittermann, J. Wouter Jukema, Eero Kajantie, Jørgen K. Kanters, Line L. Kårhus, Lambertus A. L. M. Kiemeney, Margreet Kloppenburg, Brigitte Kühnel, Jari Lahti, Claudia Langenberg, Bruno Lapauw, Graham Leese, Shuo Li, David C. M. Liewald, Allan Linneberg, Jesus V. T. Lominchar, Jian’an Luan, Nicholas G. Martin, Antonela Matana, Marcel E. Meima, Thomas Meitinger, Ingrid Meulenbelt, Braxton D. Mitchell, Line T. Møllehave, Samia Mora, Silvia Naitza, Matthias Nauck, Romana T. Netea-Maier, Raymond Noordam, Casia Nursyifa, Yukinori Okada, Stefano Onano, Areti Papadopoulou, Colin N. A. Palmer, Cristian Pattaro, Oluf Pedersen, Annette Peters, Maik Pietzner, Ozren Polašek, Peter P. Pramstaller, Bruce M. Psaty, Ante Punda, Debashree Ray, Paul Redmond, J. Brent Richards, Paul M. Ridker, Tom C. Russ, Kathleen A. Ryan, Morten Salling Olesen, Ulla T. Schultheiss, Elizabeth Selvin, Moneeza K. Siddiqui, Carlo Sidore, P. Eline Slagboom, Thorkild I. A. Sørensen, Enrique Soto-Pedre, Tim D. Spector, Beatrice Spedicati, Sundararajan Srinivasan, John M. Starr, David J. Stott, Toshiko Tanaka, Vesela Torlak, Stella Trompet, Johanna Tuhkanen, André G. Uitterlinden, Erik B. van den Akker, Tibbert van den Eynde, Melanie M. van der Klauw, Diana van Heemst, Charlotte Verroken, W. Edward Visser, Dina Vojinovic, Henry Völzke, Melanie Waldenberger, John P. Walsh, Nicholas J. Wareham, Stefan Weiss, Cristen J. Willer, Scott G. Wilson, Bruce H. R. Wolffenbuttel, Hanneke J. C. M. Wouters, Margaret J. Wright, Qiong Yang, Tatijana Zemunik, Wei Zhou, Gu Zhu, Sebastian Zöllner, Johannes W. A. Smit, Robin P. Peeters, Anna Köttgen, Alexander Teumer, Marco Medici

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)

Abstract To date only a fraction of the genetic footprint of thyroid function has been clarified. We report a genome-wide association study meta-analysis of thyroid function in up to 271,040 individuals of European ancestry, including reference range

Externí odkaz: https://doaj.org/article/87582eb11e3e4880b14ffaaf73048c8f

A Digitally Enabled Combined Lifestyle Intervention for Weight Loss: Pilot Study in a Dutch General Population Cohort

Autor: Rahul Gannamani, José Castela Forte, Pytrik Folkertsma, Sven Hermans, Sridhar Kumaraswamy, Sipko van Dam, Niels Chavannes, Hendrikus van Os, Hanno Pijl, Bruce H R Wolffenbuttel

Publikováno v: JMIR Formative Research, Vol 8, p e38891 (2024)

BackgroundOverweight and obesity rates among the general population of the Netherlands keep increasing. Combined lifestyle interventions (CLIs) focused on physical activity, nutrition, sleep, and stress management can be effective in reducing weight

Externí odkaz: https://doaj.org/article/4122b0516b9044df888bbf5062d0fd31

1型糖尿病管理的改进空间

Autor: Rita D. M. Varkevisser, Erwin Birnie, Dick Mul, Peter R. vanDijk, Henk‐Jan Aanstoot, Bruce H. R. Wolffenbuttel, Melanie M. van derKlauw

Publikováno v: Journal of Diabetes, Vol 15, Iss 3, Pp 255-263 (2023)

Abstract Aims/Hypothesis Optimal diabetes care and risk factor management are important to delay micro‐ and macrovascular complications in individuals with type 1 diabetes (T1D). Ongoing improvement of management strategies requires the evaluation

Externí odkaz: https://doaj.org/article/f80823cf92da4c629d653a58b55bb15c

The necessity of incorporating non-genetic risk factors into polygenic risk score models

Autor: Sipko van Dam, Pytrik Folkertsma, Jose Castela Forte, Dylan H. de Vries, Camila Herrera Cunillera, Rahul Gannamani, Bruce H. R. Wolffenbuttel

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)

Abstract The growing public interest in genetic risk scores for various health conditions can be harnessed to inspire preventive health action. However, current commercially available genetic risk scores can be deceiving as they do not consider other

Externí odkaz: https://doaj.org/article/34f91c869de34f0d899581adfde174e4