Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Bruce H Howard"'
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0191033 (2018)
Substantial evidence has accumulated linking epigenome change to alterations in stem cell function during postnatal development and aging. Yet much remains to be learned about causal relationships, and large gaps remain in our understanding of epigen
Externí odkaz:
https://doaj.org/article/dd1433e54cdb447d873a56e6b959fd7e
Autor:
Bruce H. Howard
Publikováno v:
Growth Control During Cell Aging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aded2880add5bace3b49cc3f78dd2c6c
https://doi.org/10.1201/9781003068150-17
https://doi.org/10.1201/9781003068150-17
Autor:
Stephen Hartley, Alice Ignezweski, Bo Yu, Valya R. Russanova, Silvia Gravina, James C. Mullikin, Bruce H. Howard, James H. Segars, Alan H. DeCherney, J.R. Graham
Publikováno v:
Oncotarget
// Bo Yu 1 , Valya R. Russanova 2 , Silvia Gravina 3 , Stephen Hartley 4 , James C. Mullikin 4, 5 , Alice Ignezweski 6 , James Graham 6 , James H. Segars 7 , Alan H. DeCherney 7 , Bruce H. Howard 2 1 Department of Obstetrics and Gynecology & Women's
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::259543dfa0e56b29b6ed4ed1c853f638
https://doi.org/10.18632/oncotarget.2875
https://doi.org/10.18632/oncotarget.2875
Publikováno v:
Nucleic Acids Research
TFIIIB and TFIIIC are multi-subunit factors required for transcription by RNA polymerase III. We present a genome-wide high-resolution footprint map of TFIIIB–TFIIIC complexes in Saccharomyces cerevisiae, obtained by paired-end sequencing of microc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bb85265c009c43aac98cc9589407c5d
https://doi.org/10.1093/nar/gkt611
https://doi.org/10.1093/nar/gkt611
Autor:
Valya R. Russanova, Thomae G. Sourlingas, Roberto Romero, Jonathan I. Epstein, Kalliope E. Sekeri-Pataryas, Paraskevi Salpea, Bruce H. Howard, Tazuko H. Hirai
Publikováno v:
Nucleic Acids Research
Alterations in DNA methylation have been reported to occur during development and aging; however, much remains to be learned regarding post-natal and age-associated epigenome dynamics, and few if any investigations have compared human methylome patte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5de8a67d52e6df0b71d2aca212c0365a
https://doi.org/10.1093/nar/gks312
https://doi.org/10.1093/nar/gks312
Publikováno v:
Nucleic Acids Research
We have used paired-end sequencing of yeast nucleosomal DNA to obtain accurate genomic maps of nucleosome positions and occupancies in control cells and cells treated with 3-aminotriazole (3AT), an inducer of the transcriptional activator Gcn4. In co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26bce54f875c9e6001597ff7059098d6
http://europepmc.org/articles/PMC3239181
http://europepmc.org/articles/PMC3239181
The centromeric nucleosome of budding yeast is perfectly positioned and covers the entire centromere
Publikováno v:
Proceedings of the National Academy of Sciences. 108:12687-12692
The centromeres of budding yeast are ∼120 bp in size and contain three functional elements: an AT-rich region flanked by binding sites for Cbf1 and CBF3. A specialized nucleosome containing the H3 variant Cse4 (CenH3) is formed at the centromere. O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62051758e1db6ccc641f99a24bee0d40
https://doi.org/10.1073/pnas.1104978108
https://doi.org/10.1073/pnas.1104978108
Publikováno v:
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 59:1234-1243
Common to numerous differentiation pathways in vertebrate organisms is the regulation of key genes through epigenetic mechanisms. Less well studied is to what extent cells of a given differentiation state, but examined at different points within the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e8bad6c102941fc5454c3f53fb56046
https://doi.org/10.1093/gerona/59.12.1234
https://doi.org/10.1093/gerona/59.12.1234
Autor:
Yonghong Wang, Keiko Ozato, Richard M. Siegel, Shigakazu Sasaki, Tomohiko Kanno, Satoshi Yamagoe, Bruce H. Howard, Yoshihiro Nakatani, Yuka Kanno, Glen Humphrey, Michael J. Lenardo
Publikováno v:
Molecular and Cellular Biology. 23:1025-1033
Having opposing enzymatic activities, histone acetylases (HATs) and deacetylases affect chromatin and regulate transcription. The activities of the two enzymes are thought to be balanced in the cell by an unknown mechanism that may involve their dire
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c639d2123fe869cecdd298026615d819
https://doi.org/10.1128/mcb.23.3.1025-1033.2003
https://doi.org/10.1128/mcb.23.3.1025-1033.2003
Autor:
Tazuko H. Hirai, Bruce H. Howard, Yoshihiro Nakatani, Jun Qin, Yonghong Wang, Glen Humphrey, Valya R. Russanova
Publikováno v:
Journal of Biological Chemistry. 276:6817-6824
Human histone deacetylases I (HDAC1) and II (HDAC2) are homologous proteins (84% identity) that catalyze release of acetyl groups from modified N-terminal lysines of core histones. Histone deacetylation is correlated with both transient and persisten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5894167c5957c1577f276644db4d9f4
https://doi.org/10.1074/jbc.m007372200
https://doi.org/10.1074/jbc.m007372200