Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Bruce H, Horwitz"'
Autor:
Carly G. K. Ziegler, Anna H. Owings, Michelle Galeas-Pena, Samuel W. Kazer, Vincent N. Miao, Andrew W. Navia, Ying Tang, Joshua D. Bromley, Peter Lotfy, Meredith Sloan, Hannah Laird, Haley B. Williams, Micayla George, Riley S. Drake, Yilianys Pride, George E. Abraham, Michal Senitko, Tanya O. Robinson, Gill Diamond, Michail S. Lionakis, Alex K. Shalek, Jose Ordovas-Montanes, Bruce H. Horwitz, Sarah C. Glover
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 6 (2024)
ABSTRACT Recent case reports and epidemiological data suggest that fungal infections represent an underappreciated complication among people with severe COVID-19. However, the frequency of fungal colonization in patients with COVID-19 and association
Externí odkaz:
https://doaj.org/article/a7e7a9fbe87a46db9ef1b7216c890566
Autor:
Nadège Nziza, Yixiang Deng, Lianna Wood, Navneet Dhanoa, Naomi Dulit-Greenberg, Tina Chen, Abigail S. Kane, Zoe Swank, Jameson P. Davis, Melina Demokritou, Anagha P. Chitnis, Alessio Fasano, Andrea G. Edlow, Nitya Jain, Bruce H. Horwitz, Ryan P. McNamara, David R. Walt, Douglas A. Lauffenburger, Boris Julg, Wayne G. Shreffler, Galit Alter, Lael M. Yonker
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Although young children generally experience mild symptoms following infection with SARS-CoV-2, severe acute and long-term complications can occur. SARS-CoV-2 mRNA vaccines elicit robust immunoglobulin profiles in children ages 5 years and o
Externí odkaz:
https://doaj.org/article/53fe3275b82d4cd68308952abe3b3f33
Autor:
Shorouk El Sayed, Izabel Patik, Naresh S. Redhu, Jonathan N. Glickman, Konstantinos Karagiannis, El Sayed Y. El Naenaeey, Gamal A. Elmowalid, Ashraf M. Abd El Wahab, Scott B. Snapper, Bruce H. Horwitz
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Macrophages are a heterogeneous population of mononuclear phagocytes abundantly distributed throughout the intestinal compartments that adapt to microenvironmental specific cues. In adult mice, the majority of intestinal macrophages exhibit
Externí odkaz:
https://doaj.org/article/cf271eddbfdf4833a4ddca73cf284aa3
Autor:
Amy M. Tsou, Jeremy A. Goettel, Bin Bao, Amlan Biswas, Yu Hui Kang, Naresh S. Redhu, Kaiyue Peng, Gregory G. Putzel, Jeffrey Saltzman, Ryan Kelly, Jordan Gringauz, Jared Barends, Mai Hatazaki, Sandra M. Frei, Rohini Emani, Ying Huang, Zeli Shen, James G. Fox, Jonathan N. Glickman, Bruce H. Horwitz, Scott B. Snapper
Publikováno v:
Microbiome, Vol 9, Iss 1, Pp 1-17 (2021)
Abstract Background The gut microbiome is altered in patients with inflammatory bowel disease, yet how these alterations contribute to intestinal inflammation is poorly understood. Murine models have demonstrated the importance of the microbiome in c
Externí odkaz:
https://doaj.org/article/5dc4ac88ab5f400b9de6cbbeae362a98
Autor:
Grigory Ryzhakov, Nathaniel R. West, Fanny Franchini, Simon Clare, Nicholas E. Ilott, Stephen N. Sansom, Samuel J. Bullers, Claire Pearson, Alice Costain, Alun Vaughan-Jackson, Jeremy A. Goettel, Joerg Ermann, Bruce H. Horwitz, Ludovico Buti, Xin Lu, Subhankar Mukhopadhyay, Scott B. Snapper, Fiona Powrie
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
The Hiccs locus has been associated with susceptibility to colitis in mice. Here the authors identify a Hiccs locus gene encoding Alpha kinase 1 as a potent regulator of intestinal inflammation via modulation of the IL-12/Th1 axis.
Externí odkaz:
https://doaj.org/article/cd1515a1c0414a6e99b0e45f27672c4a
Autor:
Amlan Biswas, Dror S. Shouval, Alexandra Griffith, Jeremy A. Goettel, Michael Field, Yu Hui Kang, Liza Konnikova, Erin Janssen, Naresh Singh Redhu, Adrian J. Thrasher, Talal Chatila, Vijay K. Kuchroo, Raif S Geha, Luigi D. Notarangelo, Sung-Yun Pai, Bruce H. Horwitz, Scott B. Snapper
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Deficiency in Wiskott-Aldrich syndrome protein (WASP) has been associated with autoimmune colitis, but the underlying mechanism is still unclear. Here the authors show that WASP deficiency is associated with defective WASP/DOCK8 complex formation, al
Externí odkaz:
https://doaj.org/article/d6407c36dbee4770a2372e3380f5d795
Autor:
Izabel Patik, Naresh S. Redhu, Alal Eran, Bin Bao, Anubhab Nandy, Ying Tang, Shorouk El Sayed, Zeli Shen, Jonathan Glickman, James G. Fox, Scott B. Snapper, Bruce H. Horwitz
Publikováno v:
Mucosal Immunology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::312adf3dea20f4deb2a4ad7358d0f9ec
https://doi.org/10.1016/j.mucimm.2023.02.006
https://doi.org/10.1016/j.mucimm.2023.02.006
Autor:
Carly G. K. Ziegler, Anna H. Owings, Vincent N. Miao, Andrew W. Navia, Ying Tang, Joshua D. Bromley, Peter Lotfy, Meredith Sloan, Hannah Laird, Haley B. Williams, Micayla George, Riley S. Drake, Yilianys Pride, George E. Abraham, Michal Senitko, Tanya O. Robinson, Michail S. Lionakis, Alex K. Shalek, Jose Ordovas-Montanes, Bruce H. Horwitz, Sarah C. Glover
Recent case reports and epidemiological data suggest fungal infections represent an under-appreciated complication among people with severe COVID-19. However, the frequency of fungal colonization in patients with COVID-19 and associations with specif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d01c2c0798e2ae32645d918de27f18cf
https://doi.org/10.1101/2022.10.25.22281528
https://doi.org/10.1101/2022.10.25.22281528
Autor:
Izabel Patik, Naresh S. Redhu, Alal Eran, Bin Bao, Anubhab Nandy, Ying Tang, Shorouk El Sayed, Zeli Shen, Jonathan Glickman, James G. Fox, Scott B. Snapper, Bruce H. Horwitz
Loss of IL-10R function leads to severe early onset colitis and in murine models is associated with the accumulation of immature inflammatory colonic macrophages. We have shown that IL-10R-deficient colonic macrophages exhibit increased STAT1-depende
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18c5f9facf4254a02f027d62bd9df05b
https://doi.org/10.1101/2022.09.01.505766
https://doi.org/10.1101/2022.09.01.505766
Autor:
Naresh S Redhu, Vasudevan Bakthavatchalu, Evan A Conaway, Dror S Shouval, Amy Tsou, Jeremy A Goettel, Amlan Biswas, Chuanwu Wang, Michael Field, Werner Muller, Andre Bleich, Ning Li, Georg K Gerber, Lynn Bry, James G Fox, Scott B Snapper, Bruce H Horwitz
Publikováno v:
eLife, Vol 6 (2017)
Infants with defects in the interleukin 10 receptor (IL10R) develop very early onset inflammatory bowel disease. Whether IL10R regulates lamina propria macrophage function during infant development in mice and whether macrophage-intrinsic IL10R signa
Externí odkaz:
https://doaj.org/article/724f8523dc5d4a638ab2b5308f22edd9