Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Bruce G Gold"'
Tyrphostin A9 protects axons in experimental autoimmune encephalomyelitis through activation of ERKs
Autor:
Xiaodong Dai, Yongmei Wang, Yuexin Li, Yongping Zhong, Min Pei, Jing Long, Xingchen Dong, Yi-Li Chen, Qi Wang, Guifeng Wang, Bruce G. Gold, Arthur A. Vandenbark, Kim A. Neve, Halina Offner, Chunhe Wang
Publikováno v:
Life Sci
AIMS: Small molecule compound tyrphostin A9 (A9), an inhibitor of platelet-derived growth factor (PDGF) receptor, was previously reported by our group to stimulate extracellular signal-regulated kinase 1 (ERK1) and 2 (ERK2) in neuronal cells in a PDG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3de6d713b0507086665312f27e28df8a
https://pubmed.ncbi.nlm.nih.gov/35143827
https://pubmed.ncbi.nlm.nih.gov/35143827
Autor:
Amala Soumyanath, Yong-Ping Zhong, Edward Henson, Teri Wadsworth, James Bishop, Bruce G. Gold, Joseph F. Quinn
Publikováno v:
International Journal of Alzheimer's Disease, Vol 2012 (2012)
Centella asiatica (CA), commonly named gotu kola, is an Ayurvedic herb used to enhance memory and nerve function. To investigate the potential use of CA in Alzheimer's disease (AD), we examined the effects of a water extract of CA (GKW) in the Tg2576
Externí odkaz:
https://doaj.org/article/6e6fd24579534ae5a04a9f593716b8d7
Autor:
Gregory G. Burrows, Laurie J. Kaler, Bruce G. Gold, Chunhe Wang, Dennis Bourdette, Michael Afentoulis, Halina Offner, Xiaolin Yu, Arthur A. Vandenbark
Publikováno v:
Journal of Neurochemistry. 98:1817-1827
The early inflammatory phase of multiple sclerosis (MS) is believed to involve an autoimmune process similar to that induced in experimental autoimmune encephalomyelitis (EAE) upon immunization with myelin antigens in adjuvants. In both instances it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b30a046f2db7cbc28cf156a60a8106e
https://doi.org/10.1111/j.1471-4159.2006.04081.x
https://doi.org/10.1111/j.1471-4159.2006.04081.x
Publikováno v:
Journal of Neurotrauma. 22:1150-1161
We have previously shown that FK506 accelerates the rate of nerve regeneration in the peripheral nervous system (PNS) and increases regeneration of central nervous system (CNS) axons into a peripheral nerve graft. In the present study, we examined wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::606cce2f8e046f5f906fc208b0c87e03
https://doi.org/10.1089/neu.2005.22.1150
https://doi.org/10.1089/neu.2005.22.1150
Publikováno v:
Expert Opinion on Therapeutic Patents. 15:555-573
Immunophilins are a family of binding proteins that are highly conserved in nature and mediate the actions of immunosuppressant drugs. The FK-506-binding protein (FKBP) subclass of immunophilin bind FK-506 and rapamycin and are of particular interest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4d7cc3a76169972b67c311c39dc6abf
https://doi.org/10.1517/13543776.15.5.555
https://doi.org/10.1517/13543776.15.5.555
Autor:
Bruce L. Patton, Bruce G. Gold, Thomas M. Proctor, Dongren Yang, Yukie S. Tarumi, Yong Ping Zhong, Larry S. Sherman, Jeffrey H. Miner, Shin'ichi Takeda, Yuko Miyagoe-Suzuki, Jesse Bierman, Reshma Rangwala
Publikováno v:
The Journal of Cell Biology
Schwann cells form basal laminae (BLs) containing laminin-2 (Ln-2; heterotrimer alpha2beta1gamma1) and Ln-8 (alpha4beta1gamma1). Loss of Ln-2 in humans and mice carrying alpha2-chain mutations prevents developing Schwann cells from fully defasciculat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e835509d6c59f5f163da0ed88d6ad63b
https://doi.org/10.1083/jcb.200411158
https://doi.org/10.1083/jcb.200411158
Autor:
Bruce G. Gold, Nobuya Matsuoka, Kaori Hanaoka, Masayuki Ishiye, Shunji Yamazaki, Ichiro Aramori, Raymond D. Price, Yasuyuki Higashi, Hiroko Yamamoto, Takehiko Yanagihara, Seitaro Mutoh, Takayuki Yamaji
Publikováno v:
European Journal of Pharmacology. 509:11-19
Immunophilin ligands are neuroregenerative agents, characterized by binding to FK506 binding proteins (FKBPs), which stimulate recovery of neurons in a variety of injury paradigms. Here we report the discovery of a novel, non-immunosuppressive immuno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6c579cb529b90bea26132c8a9dafb64
https://doi.org/10.1016/j.ejphar.2004.12.023
https://doi.org/10.1016/j.ejphar.2004.12.023
Publikováno v:
Neurological Research. 26:371-380
FK506 (tacrolimus, Prograf®) is an immunosuppressant drug that also has profound neuroregenerative and neuroprotective actions independent of its immunosuppressant activity. The separation of these properties has led to the development of non-immuno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23ff4eedad6a83021513f01f565b420a
https://doi.org/10.1179/016164104225013734
https://doi.org/10.1179/016164104225013734
Autor:
Mónica Espejo, Bruce G. Gold, Xavier Navarro, Francisco Rodríguez, Enrique Verdú, Esther Udina
Publikováno v:
Glia. 47:120-129
We assessed the effects of FK506 administration on regeneration after a 6-mm gap repair with a collagen guide seeded with allogeneic Schwann cells (SCs) in the mouse sciatic nerve. SCs were isolated from predegenerated adult sciatic nerves and expand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e79215f65896af1f2e4a79383abd0830
https://doi.org/10.1002/glia.20025
https://doi.org/10.1002/glia.20025
Autor:
Bruce G. Gold, Yong-Ping Zhong
Publikováno v:
Neurosignals. 13:122-129
The immunosuppressant drug FK506 (tacrolimus) accelerates nerve regeneration in vivo and increases neurite elongation in vitro. We have proposed that the mechanism involves binding to the FK506-binding protein 52, a chaperone component of mature ster
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da15e6a48157e220d8c4fa2c2560ee87
https://doi.org/10.1159/000076565
https://doi.org/10.1159/000076565