Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Bruce F. McEwen"'
Autor:
Alexey Khodjakov, Valentin Magidson, Fioranna Renda, Vitali Sikirzhytski, Bruce F. McEwen, Irina Tikhonenko
Publikováno v:
The Journal of Cell Biology
Correlative light electron microscopy reveals microtubule assembly near most kinetochores at the onset of mitosis in human cells. Conversion of the initially lateral interactions between these microtubules and kinetochores into end-on attachments is
Autor:
Deborah J Springer, Ping Ren, Ramesh Raina, Yimin Dong, Melissa J Behr, Bruce F McEwen, Samuel S Bowser, William A Samsonoff, Sudha Chaturvedi, Vishnu Chaturvedi
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e10978 (2010)
Cryptococcus gattii, an emerging fungal pathogen of humans and animals, is found on a variety of trees in tropical and temperate regions. The ecological niche and virulence of this yeast remain poorly defined. We used Arabidopsis thaliana plants and
Externí odkaz:
https://doaj.org/article/6431316072d74969b7224272574abde7
Autor:
Jeffrey G. Ault, Valentin Magidson, Raja Paul, Christopher B. O'Connell, Alexey Khodjakov, Alex Mogilner, Nachen Yang, Irina Tikhonenko, Bruce F. McEwen
Publikováno v:
Nature cell biology
Mitotic spindle formation relies on the stochastic capture of microtubules at kinetochores. Kinetochore architecture affects the efficiency and fidelity of this process with large kinetochores expected to accelerate assembly at the expense of accurac
Autor:
Jonathan B. Steinman, Tarun M. Kapoor, Jeffrey G. Ault, Alexey Khodjakov, Vitali Sikirzhytski, Maël Le Berre, Matthieu Piel, Jie He, James K. Chen, Haixin Sui, Bruce F. McEwen, Valentin Magidson, Irina Tikhonenko
Publikováno v:
The Journal of Cell Biology
In the absence of continuous K-fiber attachment between each kinetochore and the spindle pole, one or more additional mechanisms dependent on dynein-mediated kinetochore transport exist to ensure proper chromosome segregation during mitosis.
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Autor:
Bruce F. McEwen, Jie He, Jeffrey G. Ault, Christopher B. O'Connell, Alexey Khodjakov, Haixin Sui, Nachen Yang, Irina Tikhonenko, Valentin Magidson
Publikováno v:
The Journal of Cell Biology
Taxol induces extensive structural reorganization of the mammalian kinetochore; however, this reorganization is not sufficient to maintain a long-term mitotic arrest unless some of the kinetochores completely lose their attachment to microtubules.
Autor:
Song-Tao Liu, Jennifer G. DeLuca, Bruce F. McEwen, Walt E. Gall, Christopher W. Carroll, Edward D. Salmon, Arshad Desai, Ajit P. Joglekar, Xiaohu Wan, Ryan P. O'Quinn, Heather L. Pierce, P. Todd Stukenberg, Tim J. Yen
Publikováno v:
Cell. 137(4):672-684
SummaryChromosome segregation requires assembly of kinetochores on centromeric chromatin to mediate interactions with spindle microtubules and control cell-cycle progression. To elucidate the protein architecture of human kinetochores, we developed a
Autor:
Tatsuo Fukagawa, Wei-Hao Shang, Julie P.I. Welburn, Iain M. Cheeseman, Katsuya Okawa, Chelsea B. Backer, Emiko Suzuki, Aussie Suzuki, Tetsuya Hori, Miho Amano, Yimin Dong, Bruce F. McEwen
Publikováno v:
Cell. 135(6):1039-1052
SummaryKinetochore specification and assembly requires the targeted deposition of specialized nucleosomes containing the histone H3 variant CENP-A at centromeres. However, CENP-A is not sufficient to drive full-kinetochore assembly, and it is not cle
Publikováno v:
Nature Cell Biology. 9:516-522
Intricate interactions between kinetochores and microtubules are essential for the proper distribution of chromosomes during mitosis. A crucial long-standing question is how vertebrate kinetochores generate chromosome motion while maintaining attachm
Autor:
Xing Meng, Polla Hergert, Helder Maiato, Rita M. Barnard, Bruce F. McEwen, Kristin J. VandenBeldt
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
SummaryChromosome alignment during mitosis is frequently accompanied by a dynamic switching between elongation and shortening of kinetochore fibers (K-fibers) that connect kinetochores and spindle poles [1, 2]. In higher eukaryotes, mature K-fibers c
Autor:
Christopher N. English, Polla Hergert, Bruce F. McEwen, Greenfield Sluder, Alexey Khodjakov, Sabrina La Terra
Publikováno v:
The Journal of Cell Biology
It has been reported that nontransformed mammalian cells become arrested during G1 in the absence of centrioles (Hinchcliffe, E., F. Miller, M. Cham, A. Khodjakov, and G. Sluder. 2001. Science. 291:1547–1550). Here, we show that removal of resident