Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Bruce F, Smith"'
Autor:
Yoshimi Iwaki, Stephanie E. S. Lindley, Noelle Bergman, Bruce F. Smith, Satyanarayana R. Pondugula
Publikováno v:
Frontiers in Veterinary Science, Vol 11 (2024)
IntroductionOsteosarcoma (OSA) is an aggressive form of bone cancer in both dogs and humans. The treatment options for metastatic (stage III) OSA are currently limited and the prognosis is poor. Zoledronate, a second generation amino-bisphosphonate,
Externí odkaz:
https://doaj.org/article/bd6c6d133d6e49989c3446a0d55edac3
Autor:
Theresa A. Higgins, Daniel J. Patton, Isabella M. Shimko-Lofano, Timothy L. Eller, Roberto Molinari, Maninder Sandey, Aliaa Ismail, Bruce F. Smith, Payal Agarwal
Publikováno v:
Cells, Vol 13, Iss 4, p 351 (2024)
Osteosarcoma (OS) is a primary bone malignancy characterized by an aggressive nature, limited treatment options, low survival rate, and poor patient prognosis. Conditionally replicative adenoviruses (CRAds) armed with immune checkpoint inhibitors hol
Externí odkaz:
https://doaj.org/article/5525c390cecc426db9b8c18601abe347
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 22, p 16365 (2023)
Osteosarcoma (OSA) is a highly aggressive bone tumor primarily affecting pediatric or adolescent humans and large-breed dogs. Canine OSA shares striking similarities with its human counterpart, making it an invaluable translational model for uncoveri
Externí odkaz:
https://doaj.org/article/c158e4bf834c45a4a65f887c7f65cccd
Publikováno v:
Genes, Vol 14, Iss 7, p 1375 (2023)
MicroRNAs (miRNAs) are single-stranded, non-coding RNA molecules that regulate gene expression post-transcriptionally by binding to messenger RNAs. miRNAs are important regulators of gene expression, and their dysregulation is implicated in many huma
Externí odkaz:
https://doaj.org/article/f60dc7929835429da42f8d7c2bf545ba
Autor:
Chady H. Hakim, Sandeep R. P. Kumar, Dennis O. Pérez-López, Nalinda B. Wasala, Dong Zhang, Yongping Yue, James Teixeira, Xiufang Pan, Keqing Zhang, Emily D. Million, Christopher E. Nelson, Samantha Metzger, Jin Han, Jacqueline A. Louderman, Florian Schmidt, Feng Feng, Dirk Grimm, Bruce F. Smith, Gang Yao, N. Nora Yang, Charles A. Gersbach, Shi-jie Chen, Roland W. Herzog, Dongsheng Duan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The Cas9-specific T cell response has been speculated to impair CRISPR therapy. Here, the authors show that local and systemic AAV CRISPR therapy induces cytotoxic killing and eliminates rescued dystrophin in canine models of Duchenne muscular dystro
Externí odkaz:
https://doaj.org/article/fa789cec57864e868cf64db8cae359c5
Autor:
Jonathan Marable, Damien Ruiz, Anil K. Jaiswal, Ritankar Bhattacharya, Robert Pantazes, Payal Agarwal, Amol S. Suryawanshi, Deepa Bedi, Amarjit Mishra, Bruce F. Smith, Maninder Sandey
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Cancer is the leading cause of death in the geriatric dog population. Currently, the use of immune checkpoint inhibitors (ICIs) such as anti-CTLA4 antibodies has markedly improved the prognosis of several cancers in their advanced stages. Ho
Externí odkaz:
https://doaj.org/article/a1254a4909ce448fbb10ccd72cd4ca3b
Autor:
Damien Ruiz, Chloe Haynes, Jonathan Marable, Chetan Pundkar, Rebecca L. Nance, Deepa Bedi, Payal Agarwal, Amol S. Suryawanshi, Amarjit Mishra, Bruce F. Smith, Maninder Sandey
Publikováno v:
iScience, Vol 25, Iss 10, Pp 105158- (2022)
Summary: Recent breakthroughs in cancer immunotherapy have provided unprecedented clinical benefits to human cancer patients. Cancer is also one of the most common causes of death in pet dogs. Thus, canine-specific immune therapies targeting similar
Externí odkaz:
https://doaj.org/article/9054f4d3c2764d04bfb6e231f7445b53
Autor:
Jessica S. Fortin, Chady H. Hakim, Scott Korte, N. Nora Yang, Scott D. Fitzgerald, Gayle C. Johnson, Bruce F. Smith, Dongsheng Duan
Publikováno v:
Veterinary Medicine and Science, Vol 7, Iss 3, Pp 654-659 (2021)
Abstract The University of Missouri (MU) has established a colony of dystrophin‐deficient dogs with a mixed breed background to mirror the variable pathologic effects of dystrophinopathies between persons of a given kindred to further the understan
Externí odkaz:
https://doaj.org/article/351578939fd147a5a0fbbf1e34e6eb7d
Autor:
Madison D. Hogans, Will P. Kretzschmar, Theresa A. Higgins, Atonu Chakrabortty, Rebecca L. Nance, Bruce F. Smith, Deepa Bedi, Maninder Sandey, Payal Agarwal
Publikováno v:
Advances in Virology, Vol 2022 (2022)
Canine adenovirus type 2 (CAV2) is a nonhuman adenovirus with a known ability to infect human and canine cells. The cell surface receptors involved in CAV2 transduction are still unknown. Identification of these would provide valuable information to
Externí odkaz:
https://doaj.org/article/19ee01877e3b4f32830789c324628e66
Autor:
Payal Agarwal, Melissa P. Crepps, Natalie A. Stahr, Will P. Kretzschmar, Hannah C. Harris, Nripesh Prasad, Shawn E. Levy, Bruce F. Smith
Publikováno v:
Biochemistry and Biophysics Reports, Vol 28, Iss , Pp 101106- (2021)
Delay in cancer diagnosis often results in metastasis and an inability to successfully treat the tumor. The use of broadly cancer-specific biomarkers at an early stage may improve cancer treatment and staging. This study has explored circulatory exos
Externí odkaz:
https://doaj.org/article/f9b076c0f35140f8b5584627315546ae