Zobrazeno 1 - 10
of 179
pro vyhledávání: '"Bruce E. Torbett"'
Autor:
Krista A. Delviks-Frankenberry, Chet R. Ojha, Kip J. Hermann, Wei-Shau Hu, Bruce E. Torbett, Vinay K. Pathak
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 33, Iss , Pp 794-809 (2023)
Gene therapy strategies that effectively inhibit HIV-1 replication are needed to reduce the requirement for lifelong antiviral therapy and potentially achieve a functional cure. We previously designed self-activating lentiviral vectors that efficient
Externí odkaz:
https://doaj.org/article/70c860cc373b40bdaec6dcc5a4b940e3
Autor:
Eirini Vamva, Stosh Ozog, Daniel P. Leaman, Rene Yu-Hong Cheng, Nicholas J. Irons, Andee Ott, Claire Stoffers, Iram Khan, Geraldine K.E. Goebrecht, Matthew R. Gardner, Michael Farzan, David J. Rawlings, Michael B. Zwick, Richard G. James, Bruce E. Torbett
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 28, Iss , Pp 366-384 (2023)
Barriers to effective gene therapy for many diseases include the number of modified target cells required to achieve therapeutic outcomes and host immune responses to expressed therapeutic proteins. As long-lived cells specialized for protein secreti
Externí odkaz:
https://doaj.org/article/5335a8f9645a42be9c9d7d049a240b62
Autor:
Kristina Seiler, Magali Humbert, Petra Minder, Iris Mashimo, Anna M. Schläfli, Deborah Krauer, Elena A. Federzoni, Bich Vu, James J. Moresco, John R. Yates, Martin C. Sadowski, Ramin Radpour, Thomas Kaufmann, Jean-Emmanuel Sarry, Joern Dengjel, Mario P. Tschan, Bruce E. Torbett
Publikováno v:
Cell Death and Disease, Vol 13, Iss 5, Pp 1-14 (2022)
Abstract The family of hexokinases (HKs) catalyzes the first step of glycolysis, the ATP-dependent phosphorylation of glucose to glucose-6-phosphate. While HK1 and HK2 are ubiquitously expressed, the less well-studied HK3 is primarily expressed in he
Externí odkaz:
https://doaj.org/article/0483ca7b4b974a9db20fe6d5d5f9e6fc
Autor:
Eirini Vamva, Stosh Ozog, Els Verhoeyen, Richard G. James, David J. Rawlings, Bruce E. Torbett
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101228- (2022)
Summary: Measles virus envelope pseudotyped LV (MV-LV) can achieve high B cell transduction rates (up to 50%), but suffers from low titers. To overcome current limitations, we developed an optimized MV-LV production protocol that achieved consistent
Externí odkaz:
https://doaj.org/article/e6b7e6a73833410aad10f86653494eaf
Autor:
Krista A. Delviks-Frankenberry, Daniel Ackerman, Nina D. Timberlake, Maria Hamscher, Olga A. Nikolaitchik, Wei-Shau Hu, Bruce E. Torbett, Vinay K. Pathak
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 18, Iss , Pp 1023-1038 (2019)
Strategies to control HIV-1 replication without antiviral therapy are needed to achieve a functional cure. To exploit the innate antiviral function of restriction factor cytidine deaminase APOBEC3G (A3G), we developed self-activating lentiviral vecto
Externí odkaz:
https://doaj.org/article/8ce3c38bfdec4df3802934eb69e6970d
Autor:
Stosh Ozog, Craig X. Chen, Elizabeth Simpson, Olivia Garijo, Nina D. Timberlake, Petra Minder, Els Verhoeyen, Bruce E. Torbett
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 13, Iss , Pp 27-39 (2019)
Lentiviral vectors (LVs) pseudotyped with the measles virus hemagglutinin (H) and fusion (F) glycoproteins have been reported to more efficiently transduce hematopoietic stem and progenitor cells (HSPCs) compared with vesicular stomatitis virus glyco
Externí odkaz:
https://doaj.org/article/fddd9b144ec5464e8213e1eb8573ad39
Autor:
Koollawat Chupradit, Wannisa Khamaikawin, Supachai Sakkhachornphop, Chaniporn Puaninta, Bruce E. Torbett, Suparerk Borwornpinyo, Suradej Hongeng, Methichit Wattanapanitch, Chatchai Tayapiwatana
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 4, p 2331 (2022)
Human hematopoietic stem/progenitor cell (HSPC)-based gene therapy is a promising direction for curing HIV-1-infected individuals. The zinc finger protein (2LTRZFP) designed to target the 2-LTR-circle junction of HIV-1 cDNA was previously reported as
Externí odkaz:
https://doaj.org/article/c12db978214247a18d7bf2927091c12a
Autor:
Shentian Zhuang, Bruce E. Torbett
Publikováno v:
Viruses, Vol 13, Iss 3, p 417 (2021)
The Human Immunodeficiency Virus type 1 (HIV-1) virion contains a conical shell, termed capsid, encasing the viral RNA genome. After cellular entry of the virion, the capsid is released and ensures the protection and delivery of the HIV-1 genome to t
Externí odkaz:
https://doaj.org/article/d6fd878af4184df7ade5ac0c5e95ffd1
Autor:
Elena A. Federzoni, Severin Gloor, Jing Jin, Deborah Shan-Krauer, Martin F. Fey, Bruce E. Torbett, Mario P. Tschan
Publikováno v:
Leukemia Research Reports, Vol 4, Iss 1, Pp 32-35 (2015)
In an mRNA profiling screen performed to unveil novel mechanisms of leukemogenesis, we found that the sentrin-specific protease 5 (SENP5) was significantly repressed in clinical acute myeloid leukemia when compared to healthy neutrophil samples. SENP
Externí odkaz:
https://doaj.org/article/69215a012400486e927be1cc503d2cad
Autor:
Saritha S. D’Souza, Akhilesh Kumar, John Maufort, Jason T. Weinfurter, Matthew Raymond, Nick S. Strelchenko, Elizabeth Perrin, Jennifer Coonen, Andres Mejia, Heather A. Simmons, Bruce E. Torbett, Matthew Reynolds, James A. Thomson, Igor I. Slukvin
Publikováno v:
Blood Advances. 6:5267-5278
Administration of ex vivo expanded somatic myeloid progenitors has been explored as a way to facilitate a more rapid myeloid recovery and improve overall survival after myeloablation. Recent advances in induced pluripotent stem cell (iPSC) technologi