Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Bruce E. Seligmann"'
Autor:
Kristin D. Gerson, V. S. R. Krishna Maddula, Bruce E. Seligmann, Jeffrey R. Shearstone, Ashraf Khan, Arthur M. Mercurio
Publikováno v:
Biology Open, Vol 1, Iss 7, Pp 658-666 (2012)
Summary The integrin α6β4 is defined as an adhesion receptor for laminins. Referred to as ‘β4’, this integrin plays a key role in the progression of various carcinomas through its ability to orchestrate key signal transduction events and promo
Externí odkaz:
https://doaj.org/article/80f77a2981b643adb2d9ed3fff2c42fe
Autor:
Joanne M Yeakley, Peter J Shepard, Diana E Goyena, Harper C VanSteenhouse, Joel D McComb, Bruce E Seligmann
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0178302 (2017)
The use of gene expression signatures to classify compounds, identify efficacy or toxicity, and differentiate close analogs relies on the sensitivity of the method to identify modulated genes. We used a novel ligation-based targeted whole transcripto
Externí odkaz:
https://doaj.org/article/d403b6190c4a45f3b409e67cbb03ebb5
Autor:
Arthur M. Mercurio, Krishna Maddula, Bruce E. Seligmann, Kristin D. Gerson, Jeffrey R. Shearstone
Publikováno v:
Journal of Biological Chemistry. 287:9835-9844
The α6β4 integrin (referred to as "β4" integrin) is a receptor for laminins that promotes carcinoma invasion through its ability to regulate key signaling pathways and cytoskeletal dynamics. An analysis of published Affymetrix GeneChip data to det
Autor:
Ashraf Khan, Kristin D. Gerson, Krishna Maddula, Jeffrey R. Shearstone, Bruce E. Seligmann, Arthur M. Mercurio
Publikováno v:
Biology Open
Biology Open, Vol 1, Iss 7, Pp 658-666 (2012)
Biology Open, Vol 1, Iss 7, Pp 658-666 (2012)
Summary The integrin α6β4 is defined as an adhesion receptor for laminins. Referred to as ‘β4’, this integrin plays a key role in the progression of various carcinomas through its ability to orchestrate key signal transduction events and promo
Autor:
Natesa Muthukumaraswamy, Bruce E. Seligmann, Heinz Mueller, Shawn P. Fay, Richard J. Freer, Larry A. Sklar
Publikováno v:
Biochemistry. 29:313-316
We have studied the topography of interaction of a family of fluorescent formyl peptides containing four (CHO-Met-Leu-Phe-Lys-fluorescein), five (CHO-Met-Leu-Phe-Phe-Lys- fluorescein), and six (CHO-Nle-Leu-Phe-Nle-Tyr-Lys-fluorescein and CHO-Met-Leu-
Publikováno v:
Biological and Medical Physics, Biomedical Engineering ISBN: 9783540229315
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f81324f2cff235438ba82c0515bdad4e
https://doi.org/10.1007/3-540-26578-3_1
https://doi.org/10.1007/3-540-26578-3_1
Publikováno v:
Journal of Clinical Investigation. 68:1125-1131
Previous studies of neutrophil nitroblue tetrazolium dye reduction in response to endotoxin and rosetting of IgG-coated erythryocytes have suggested functional heterogeneity of peripheral blood neutrophils. In the following study we utilized flow mic
Publikováno v:
The Journal of Membrane Biology. 52:257-272
Changes in the fluorescence intensity of the dye 3-3' dipentyloxacarbocyanine were measured in suspensions of purified human peripheral blood polymorphonuclear leukocytes (PMNs) during exposure to the chemotactic factors N-formyl-methionyl-leucyl-phe
Autor:
John I. Gallin, Bruce E. Seligmann
Publikováno v:
Journal of Clinical Investigation. 66:493-503
Previous studies using membrane potential sensitive probes have provided evidence that chemotactic factors elicit membrane potential changes in normal human neutrophils (PMN). In addition to stimulation of PMN motility, chemotactic factors also stimu
Autor:
Kerstin Cehrs, Nancy Mounessa, Mark P. Fletcher, John I. Gallin, Sylvia Hoffstein, Bruce E. Seligmann
Publikováno v:
Blood. 59:1317-1329
It has been suggested that neutrophil (PMN) specific granules are important in cell aggregation, locomotion, hydroxyl radical formation, and in extracellular functions such as the generation of complement- related inflammatory mediators (C5a) and the