Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Bruce E. McKay"'
Publikováno v:
Developmental Psychobiology. 56:657-673
Toluene is a psychoactive chemical found in many household products including adhesives and thinners. Inhalation of these vapors can cause euphoria and impairments in motor control and neurological functioning. Misuse and abuse of toluene is most com
Publikováno v:
Behavioural Pharmacology. 23:669-677
Binge inhalation of toluene, a psychoactive chemical found in many household and industrial products, leads acutely to intoxication with comorbid impairments in motor function and cognitive abilities that appear to recover quickly. Recent evidence, h
Publikováno v:
Neurotoxicology and Teratology. 34:403-412
Toluene, a psychoactive volatile solvent found in adhesives and other products, is inhaled for its euphoric and intoxicating effects. Toluene inhalation additionally results in cognitive disturbances including impairments in select types of spatial a
Publikováno v:
Biochemical Pharmacology. 74:1120-1133
Nicotinic acetylcholine receptors (nAChRs) are widely expressed throughout the central nervous system and participate in a variety of physiological functions. Recent advances have revealed roles of nAChRs in the regulation of synaptic transmission an
Autor:
Michael L. Molineux, Terrance P. Snutch, Ray W. Turner, Gerald W. Zamponi, Jawed Hamid, Bruce E. McKay, John E. McRory
Publikováno v:
European Journal of Neuroscience. 24:2581-2594
Spike output in many neuronal cell types is affected by low-voltage-activated T-type calcium currents arising from the Cav3.1, Cav3.2 and Cav3.3 channel subtypes and their splice isoforms. The contributions of T-type current to cell output is often p
Autor:
Mircea Iftinca, John E. McRory, Terry P. Snutch, Bruce E. McKay, Gerald W. Zamponi, Ray W. Turner
Publikováno v:
Neuroscience. 142:1031-1042
T-type calcium channel isoforms are expressed in a multitude of tissues and have a key role in a variety of physiological processes. To fully appreciate the physiological role of distinct channel isoforms it is essential to determine their kinetic pr
Autor:
Bruce E. McKay, Ray W. Turner
Publikováno v:
The Journal of Physiology. 567:829-850
Cerebellar Purkinje cells integrate multimodal afferent inputs and, as the only projection neurones of the cerebellar cortex, are key to the coordination of a variety of motor- and learning-related behaviours. In the neonatal rat the cerebellum is un
Publikováno v:
The Journal of Neuroscience. 25:1481-1492
Purkinje cells (PCs) generate the sole output of the cerebellar cortex and govern the timing of action potential discharge from neurons of the deep cerebellar nuclei (DCN). Here, we examine how voltage-gated Kv1 K+channels shape intrinsically generat
Publikováno v:
The Journal of Comparative Neurology. 473:86-96
The vitamin biotin is an endogenous molecule that acts as an important cofactor for several carboxylases in the citric acid cycle. Disorders of biotin metabolism produce neurological symptoms that range from ataxia to sensory loss, suggesting the pre
Autor:
Jimmie M. Gmaz, Bruce E. McKay
Publikováno v:
Neuroscience letters. 560
Toluene belongs to a class of psychoactive drugs known as inhalants. Found in common household products such as adhesives, paint products, and aerosols, toluene is inhaled for its intoxicating and euphoric properties. Additionally, exposure to toluen