Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Bruce E. Kimmel"'
Autor:
Trevor J Wardill, Tsai-Wen Chen, Eric R Schreiter, Jeremy P Hasseman, Getahun Tsegaye, Benjamin F Fosque, Reza Behnam, Brenda C Shields, Melissa Ramirez, Bruce E Kimmel, Rex A Kerr, Vivek Jayaraman, Loren L Looger, Karel Svoboda, Douglas S Kim
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77728 (2013)
Fluorescent protein-based sensors for detecting neuronal activity have been developed largely based on non-neuronal screening systems. However, the dynamics of neuronal state variables (e.g., voltage, calcium, etc.) are typically very rapid compared
Externí odkaz:
https://doaj.org/article/260c05b0e92b4cd0a03c4417df7ccb10
Autor:
Eiji Shigetomi, Sevinç Mutlu, Andrew Gordus, Florian Engert, Loren L. Looger, John J. Macklin, Eric R. Schreiter, Aman Aggarwal, Nicole Carreras Calderón, Bruce E. Kimmel, Samuel S.-H. Wang, Douglas S. Kim, Herwig Baier, Leon Lagnado, Sebastian Kracun, Karel Svoboda, Baljit S. Khakh, Xiaonan Richard Sun, Trevor J. Wardill, Ruben Portugues, Lin Tian, Cornelia I. Bargmann, Vivek Jayaraman, Federico Esposti, Bart G. Borghuis, Jonathan S. Marvin, Alessandro Filosa, Tsai Wen Chen, Ryousuke Takagi, Michael B. Orger, Jasper Akerboom, Rex Kerr
Publikováno v:
The Journal of Neuroscience. 32:13819-13840
Genetically encoded calcium indicators (GECIs) are powerful tools for systems neuroscience. Recent efforts in protein engineering have significantly increased the performance of GECIs. The state-of-the art single-wavelength GECI, GCaMP3, has been dep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f129ce07ec26e102a535bad97cbf711
https://doi.org/10.1523/jneurosci.2601-12.2012
https://doi.org/10.1523/jneurosci.2601-12.2012
Autor:
Bruce E. Kimmel, Richard D. DiMarchi, Joel Berger, Anthony Manibusan, Zhihua Li, Qing Dallas-Yang, Margaret Wu, Dennis M. Zaller, Stuart Bussell, Jun Yao, Heather Myler, Anna-Maria A. Hays Putnam, James Mu, Nina Li, Bei B. Zhang, Thea Norman, Douglas W. Axelrod, Carlos G. Rodriguez, Jason Pinkstaff, Joseph M. Metzger, Darin Lee, Lillian Skidmore
Publikováno v:
Diabetes
Fibroblast growth factor 21 (FGF21) mitigates many of the pathogenic features of type 2 diabetes, despite a short circulating half-life. PEGylation is a proven approach to prolonging the duration of action while enhancing biophysical solubility and s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e334765339a6145bf9956f15fddc608
http://europepmc.org/articles/PMC3266413
http://europepmc.org/articles/PMC3266413
Autor:
Thea Norman, Tsotne Javahishvili, Stuart Bussell, David C. Litzinger, Stephanie Chu, Bruce E. Kimmel, Ricky Lieu, Sami Kaphle, Bee-Cheng Sim, Peter G. Schultz, Thomas L. Daniel, Mike Ong, Anna-Maria A. Hays Putnam, Zhenwei Maio, Ying Buechler, Richard D. DiMarchi, Ho Cho, Andrew R. Hoffman, Guillermo Viramontes, Paola Castiglioni, Douglas W. Axelrod, Becky Gc, Vadim Kraynov, Nick Knudsen
Publikováno v:
Proceedings of the National Academy of Sciences. 108:9060-9065
The ribosomal incorporation of nonnative amino acids into polypeptides in living cells provides the opportunity to endow therapeutic proteins with unique pharmacological properties. We report here the first clinical study of a biosynthetic protein pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5b5edb326f7ee27edbdf4cea0830975
https://doi.org/10.1073/pnas.1100387108
https://doi.org/10.1073/pnas.1100387108
Autor:
Douglas S. Reed, T.L. Clements, R.P. Dirmeier, Randal J. Schoepp, Gary Woodnutt, K. Wong, M. Keller, J. Li, E.C. Tozer, Bruce E. Kimmel, L.M. Lewis, J.Q. Li, Xuqiu Tan, Gerhard Frey, Jeff Rogers, O. Schröder, T.F. Holland
Publikováno v:
Protein Engineering, Design and Selection
Protein Engineering Design and Selection
Protein Engineering Design and Selection
Using a comprehensive set of discovery and optimization tools, antibodies were produced with the ability to neutralize SARS coronavirus (SARS-CoV) infection in Vero E6 cells and in animal models. These anti-SARS antibodies were discovered using a nov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65cef199ed1a9dd9aa6c21036f7be8da
https://doi.org/10.1093/protein/gzn027
https://doi.org/10.1093/protein/gzn027
Autor:
Bruce E. Kimmel, Gary Woodnutt, Mangala Hariharan, Geneviève Hansen, Marikka Elia, Ping Jin, Jay M. Short, Michael Dudley, Stephen J Demarest, Jared Salbato, Colin Bird
Publikováno v:
mAbs. 2(2)
The pathogenicity of Clostridium difficile (C. difficile) is mediated by the release of two toxins, A and B. Both toxins contain large clusters of repeats known as cell wall binding (CWB) domains responsible for binding epithelial cell surfaces. Seve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::355688b463cba1fc38539a499b41ce40
https://pubmed.ncbi.nlm.nih.gov/20150758
https://pubmed.ncbi.nlm.nih.gov/20150758
Publikováno v:
Ciba Foundation Symposium 179-The Molecular Basis of Smell and Taste Transduction
The small soil nematode Caenorhabditis elegans has only 302 neurons in its entire nervous system, so it is possible to analyse the functions of individual neurons in the animal's behaviour. We are using behavioural, cellular and genetic analyses of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b2afdee0b358bbd8c556ad6851ee918
https://doi.org/10.1002/9780470514511.ch15
https://doi.org/10.1002/9780470514511.ch15
Autor:
John Poland, David Gustafson, Ken Wong, Marikka Elia, Bruce E. Kimmel, Jay M. Short, Jane Wu, Stephen J. Demarest, Xuqiu Tan, Geneviève Hansen, Gang Chen, Jared Salbato
Publikováno v:
Protein engineering, designselection : PEDS. 19(7)
The recombinant expression of immunoglobulin domains, Fabs and scFvs in particular, in Escherichia coli can vary significantly from antibody to antibody. We hypothesized that poor Fab expression is often linked to poor intrinsic stability. To investi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b47474aa71c546fd6d3a94335805b4e
https://pubmed.ncbi.nlm.nih.gov/16672248
https://pubmed.ncbi.nlm.nih.gov/16672248
Autor:
Gary Woodnutt, Stephen J. Demarest, Jingping Zhong, Katie Kline, Marikka Elia, Bruce E. Kimmel, Geneviève Hansen, Theresa Morrow, Trevin Holland, Jared Salbato
Publikováno v:
Journal of molecular biology. 346(5)
Clostridium difficile ( C. difficile ) is a nosocomially acquired intestinal bacillus which can cause chronic diarrhea and life-threatening colitis. The pathogenic effects of the bacillus are mediated by the release of two toxins, A and B. The C-term
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::287fc4958385cb187761c6f649bc2184
https://pubmed.ncbi.nlm.nih.gov/15713474
https://pubmed.ncbi.nlm.nih.gov/15713474
Autor:
Mark D. Adams, Susan E. Celniker, Robert A. Holt, Cheryl A. Evans, Jeannine D. Gocayne, Peter G. Amanatides, Steven E. Scherer, Peter W. Li, Roger A. Hoskins, Richard F. Galle, Reed A. George, Suzanna E. Lewis, Stephen Richards, Michael Ashburner, Scott N. Henderson, Granger G. Sutton, Jennifer R. Wortman, Mark D. Yandell, Qing Zhang, Lin X. Chen, Rhonda C. Brandon, Yu-Hui C. Rogers, Robert G. Blazej, Mark Champe, Barret D. Pfeiffer, Kenneth H. Wan, Clare Doyle, Evan G. Baxter, Gregg Helt, Catherine R. Nelson, George L. Gabor, null Miklos, Josep F. Abril, Anna Agbayani, Hui-Jin An, Cynthia Andrews-Pfannkoch, Danita Baldwin, Richard M. Ballew, Anand Basu, James Baxendale, Leyla Bayraktaroglu, Ellen M. Beasley, Karen Y. Beeson, P. V. Benos, Benjamin P. Berman, Deepali Bhandari, Slava Bolshakov, Dana Borkova, Michael R. Botchan, John Bouck, Peter Brokstein, Phillipe Brottier, Kenneth C. Burtis, Dana A. Busam, Heather Butler, Edouard Cadieu, Angela Center, Ishwar Chandra, J. Michael Cherry, Simon Cawley, Carl Dahlke, Lionel B. Davenport, Peter Davies, Beatriz de Pablos, Arthur Delcher, Zuoming Deng, Anne Deslattes Mays, Ian Dew, Suzanne M. Dietz, Kristina Dodson, Lisa E. Doup, Michael Downes, Shannon Dugan-Rocha, Boris C. Dunkov, Patrick Dunn, Kenneth J. Durbin, Carlos C. Evangelista, Concepcion Ferraz, Steven Ferriera, Wolfgang Fleischmann, Carl Fosler, Andrei E. Gabrielian, Neha S. Garg, William M. Gelbart, Ken Glasser, Anna Glodek, Fangcheng Gong, J. Harley Gorrell, Zhiping Gu, Ping Guan, Michael Harris, Nomi L. Harris, Damon Harvey, Thomas J. Heiman, Judith R. Hernandez, Jarrett Houck, Damon Hostin, Kathryn A. Houston, Timothy J. Howland, Ming-Hui Wei, Chinyere Ibegwam, Mena Jalali, Francis Kalush, Gary H. Karpen, Zhaoxi Ke, James A. Kennison, Karen A. Ketchum, Bruce E. Kimmel, Chinnappa D. Kodira, Cheryl Kraft, Saul Kravitz, David Kulp, Zhongwu Lai, Paul Lasko, Yiding Lei, Alexander A. Levitsky, Jiayin Li, Zhenya Li, Yong Liang, Xiaoying Lin, Xiangjun Liu, Bettina Mattei, Tina C. McIntosh, Michael P. McLeod, Duncan McPherson, Gennady Merkulov, Natalia V. Milshina, Clark Mobarry, Joe Morris, Ali Moshrefi, Stephen M. Mount, Mee Moy, Brian Murphy, Lee Murphy, Donna M. Muzny, David L. Nelson, David R. Nelson, Keith A. Nelson, Katherine Nixon, Deborah R. Nusskern, Joanne M. Pacleb, Michael Palazzolo, Gjange S. Pittman, Sue Pan, John Pollard, Vinita Puri, Martin G. Reese, Knut Reinert, Karin Remington, Robert D. C. Saunders, Frederick Scheeler, Hua Shen, Bixiang Christopher Shue, Inga Sidén-Kiamos, Michael Simpson, Marian P. Skupski, Tom Smith, Eugene Spier, Allan C. Spradling, Mark Stapleton, Renee Strong, Eric Sun, Robert Svirskas, Cyndee Tector, Russell Turner, Eli Venter, Aihui H. Wang, Xin Wang, Zhen-Yuan Wang, David A. Wassarman, George M. Weinstock, Jean Weissenbach, Sherita M. Williams, Trevor Woodage, Kim C. Worley, David Wu, Song Yang, Q. Alison Yao, Jane Ye, Ru-Fang Yeh, Jayshree S. Zaveri, Ming Zhan, Guangren Zhang, Qi Zhao, Liansheng Zheng, Xiangqun H. Zheng, Fei N. Zhong, Wenyan Zhong, Xiaojun Zhou, Shiaoping Zhu, Xiaohong Zhu, Hamilton O. Smith, Richard A. Gibbs, Eugene W. Myers, Gerald M. Rubin, J. Craig Venter
Publikováno v:
Science (New York, N.Y.). 287(5461)
The fly Drosophila melanogaster is one of the most intensively studied organisms in biology and serves as a model system for the investigation of many developmental and cellular processes common to higher eukaryotes, including humans. We have determi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c5cbb524a131956126eb5117efaf414
https://pubmed.ncbi.nlm.nih.gov/10731132
https://pubmed.ncbi.nlm.nih.gov/10731132