Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Bruce E. Kaplan"'
Publikováno v:
European Journal of Immunology. 34:3102-3114
Lipopeptides, a form of peptide immunogens, are currently under intense investigation as human vaccines for many infectious pathogens and cancers. However, the cellular and molecular mechanisms of lipopeptide immunogenicity are only partially underst
Autor:
Eugene C. Gan, Christopher L. Holley, Daniel A. Colón-Ramos, Sally Kornbluth, Michael R. Olson, Bruce E. Kaplan
Publikováno v:
Journal of Biological Chemistry. 278:44758-44768
Reaper is a potent pro-apoptotic protein originally identified in a screen for Drosophila mutants defective in apoptotic induction. Multiple functions have been ascribed to this protein, including inhibition of IAPs (inhibitors of apoptosis); inducti
Publikováno v:
Journal of Molecular Biology. 303:515-529
The binding of human immunodeficiency virus type 1 (HIV-1) Rev protein to its viral RNA target, stem-loop IIB (SLIIB) within the Rev Response element (RRE), mediates the export of singly-spliced and unspliced viral mRNA from the nucleus to the cytopl
Autor:
Jung Hoon Yoon, Masashi Takao, Akira Yasui, Gerd P. Pfeifer, Binghui Shen, Piotr Swiderski, Bruce E. Kaplan
Publikováno v:
Biochemistry. 38:4809-4817
Ultraviolet (UV) irradiation induces predominantly cyclobutane and (6-4) pyrimidine dimer photoproducts in DNA. Several mechanisms for repairing these mutagenic UV-induced DNA lesions have been identified. Nucleotide excision repair is a major pathwa
Autor:
J. Strotmeier, Andreas Rummel, Karine Bagramyan, Luisa W. Cheng, Markus Kalkum, Bruce E. Kaplan
Botulinum neurotoxins (BoNTs) are used in a wide variety of medical applications, but there is limited pharmacokinetic data on active BoNT. Monitoring BoNT activity in the circulation is challenging because BoNTs are highly toxic and are rapidly take
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7546993af3d8fcb78794e86429fb20a9
https://europepmc.org/articles/PMC3748743/
https://europepmc.org/articles/PMC3748743/
Publikováno v:
Biochemistry. 35:15693-15703
The formation of DNA photoproducts by ultraviolet (UV) light is responsible for the induction of mutations and the development of skin cancer. Cis-syn cyclobutane pyrimidine dimers (pyrimidine dimers) are the most frequent lesions produced in DNA by
Autor:
James Wang, David S. Snyder, Yaping Wu, Bruce E. Kaplan, John J. Rossi, Stephen J. Forman, Piotr Swiderski
Publikováno v:
Blood. 82:600-605
The bcr-abl fusion gene is the molecular counterpart of the Philadelphia chromosome (Ph1) and is directly involved in the pathogenesis of Ph1+ leukemia. Inhibition of bcr-abl gene expression may have profound effects on the cell biology of Ph1+ cells
Publikováno v:
Biochemistry. 31:850-854
In order to specify the recognition requirements of the human DNA (cytosine-5-)-methyltransferase, two isomeric 48mers were synthesized so as to link a long block of DNA with a shorter complementary block of DNA through a tether consisting of five th
Publikováno v:
Journal of Molecular Biology. 217:39-51
The symmetry of the responses of the human DNA(cytosine-5)methyltransferase to alternative placements of 5-methylcytosine in model oligodeoxynucleotide duplexes containing unusual structures has been examined. The results of these experiments more cl
Publikováno v:
Journal of Molecular Biology. 213:303-314
An abasic site in DNA creates a strong block to DNA polymerase and is a mutagenic base lesion. In this study, we present structural and dynamic properties of duplex oligodeoxynucleotides containing G, C and T opposite a model abasic site studied by o