Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Bruce E Magun"'
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e36044 (2012)
Some inflammatory stimuli trigger activation of the NLRP3 inflammasome by inducing efflux of cellular potassium. Loss of cellular potassium is known to potently suppress protein synthesis, leading us to test whether the inhibition of protein synthesi
Externí odkaz:
https://doaj.org/article/60736c71998944ada9b6480ae7886674
Publikováno v:
Cancer Biology & Therapy. 15:1395-1403
Cytotoxic chemotherapeutic drugs, especially when used in combination, are widely employed to treat a variety of cancers in patients but often lead to serious symptoms that negatively affect physical functioning and quality of life. There is compelli
Autor:
Nicholas J. Mantis, John M. Leong, Dakshina M. Jandhyala, John B. Wong, Bruce E Magun, Cheleste M. Thorpe
Publikováno v:
Toxins, Vol 8, Iss 9, p 259 (2016)
Toxins
Toxins
Ricin activates the proinflammatory ribotoxic stress response through the mitogen activated protein 3 kinase (MAP3K) ZAK, resulting in activation of mitogen activated protein kinases (MAPKs) p38 and JNK1/2. We had a novel zak-/- mouse generated to st
Publikováno v:
Cancer Biology & Therapy. 11:1008-1016
Anthracyclines including doxorubicin and daunorubicin are commonly used for the treatment of both hematologic and solid tumors. Dose related adverse effects often limit the effectiveness of anthracyclines in chemotherapy. Drug-related systemic inflam
Publikováno v:
The Journal of Immunology. 183:1419-1426
Ricin is a potent ribotoxin considered to be a potentially dangerous bioterrorist agent due to its wide availability and the possibility of aerosol delivery to human populations. Studies in rodents and nonhuman primates have demonstrated that ricin d
Autor:
Olga P. Ryabinina, David E. Purdy, Mihail S. Iordanov, Pascal Schneider, Sherry M. Farley, Bruce E. Magun
Publikováno v:
Journal of Biological Chemistry. 283:919-928
Fas ligand (FasL) exerts potent proapoptotic and proinflammatory actions on epidermal keratinocytes and has been implicated in the pathogenesis of eczema, toxic epidermal necrolysis, and drug-induced skin eruptions. We used reconstructed human epider
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 293:L1385-L1394
Ricin is a potential bioweapon because of its toxicity, availability, and ease of production. When delivered to the lungs, ricin causes severe pulmonary damage with symptoms that are similar to those observed in acute lung injury and adult respirator
Autor:
John B. Wong, Veselina Korcheva, Mihail S. Iordanov, Meghan Lindauer, Bruce E. Magun, David B. Jacoby
Publikováno v:
Molecular Immunology. 44:2761-2771
Because of its lethal effects, ease of preparation, and ability to be delivered by aerosolization, ricin has been developed as a lethal weapon by various terrorist groups. When introduced into the pulmonary system of rodents, ricin causes pathologica
Autor:
Bruce E. Magun, Anjali D. Dotson, David E. Purdy, Mihail S. Iordanov, Pascal Schneider, Sherry M. Farley, Aaron J. Sundholm
Publikováno v:
Journal of Investigative Dermatology, vol. 126, no. 11, pp. 2438-2451
Fas ligand (FasL) causes apoptosis of epidermal keratinocytes and triggers the appearance of spongiosis in eczematous dermatitis. We demonstrate here that FasL also aggravates inflammation by triggering the expression of proinflammatory cytokines, ch
Autor:
John B. Wong, Jay A. Nelson, Jamie A. Borton, Bruce E. Magun, Amy M. Keech, William J. Britt, Michael A. Jarvis
Publikováno v:
Journal of Virology. 80:5588-5598
Viral infection is associated with a vigorous inflammatory response characterized by cellular infiltration and release of the proinflammatory cytokines interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF-alpha). In the present study, we identif