Zobrazeno 1 - 10 of 42 pro vyhledávání: '"Bruce E LeRoy"'
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Akademický článek
Computer-assisted imaging algorithms facilitate histomorphometric quantification of kidney damage in rodent renal failure models
Autor: Marcin Klapczynski, Gerard D Gagne, Sherry J Morgan, Kelly J Larson, Bruce E LeRoy, Eric A Blomme, Bryan F Cox, Eugene W Shek
Publikováno v: Journal of Pathology Informatics, Vol 3, Iss 1, Pp 20-20 (2012)
Introduction: Surgical 5/6 nephrectomy and adenine-induced kidney failure in rats are frequently used models of progressive renal failure. In both models, rats develop significant morphological changes in the kidneys and quantification of these chang
Externí odkaz: https://doaj.org/article/c2b9fec2541e4b119c6d0067d07d3693
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3
Symmetric Dimethylarginine Is a Sensitive Biomarker of Glomerular Injury in Rats
Autor: Christina Dunn, Rebecca Kohnken, Richard E. Peterson, Sabyasachi Biswas, Lauren E. Himmel, Bruce E. LeRoy, Michael Logan
Publikováno v: Toxicologic pathology. 50(2)
Glomerular filtration rate is the gold-standard method for assessment of renal function but is rarely performed in routine toxicity studies. Standard serum biomarkers of renal function are insensitive and become elevated only with significant loss of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7266e60c84e6df9e0302d725ed881d76
https://pubmed.ncbi.nlm.nih.gov/34634957
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5
Automated blood sampling in canine telemetry model: Enhanced assessment of immune liabilities
Autor: Bruce E. Leroy, Amanda S. Wilsey, Paige A. Ebert, Jie Lai-Zhang, Brandan M. Bird, Scott W. Mittelstadt, James S. Polakowski, Sabine Sadilek, Yevgeniya E. Koshman, Debra A. Weisbecker, C. Michael Foley
Publikováno v: Journal of Pharmacological and Toxicological Methods. 112:107115
Introduction This manuscript presents a successful integration of multi-timepoint biomarker blood sampling (e.g., cytokines) in a conscious dog cardiovascular study using automated blood sampling via vascular access ports in telemetry instrumented do
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a1386dd3d321374a34b88a51a69c238
https://doi.org/10.1016/j.vascn.2021.107115
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6
Measuring drug absorption improves interpretation of behavioral responses in a larval zebrafish locomotor assay for predicting seizure liability
Autor: Bruce E. Leroy, Laura Breidenbach, Amanda Olson, Steven Cassar, Heather Britton, Katja Hempel, Xin Huang, DeAnne Stolarik, Pankajkumar Sancheti, Karsten Wicke, Clarissa Woody
Publikováno v: Journal of Pharmacological and Toxicological Methods. 88:56-63
Introduction Unanticipated effects on the central nervous system are a concern during new drug development. A larval zebrafish locomotor assay can reveal seizure liability of experimental molecules before testing in mammals. Relative absorption of co
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35e5a77d481bbe614019dcf02301e821
https://doi.org/10.1016/j.vascn.2017.07.002
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7
A regenerative erythropoietic response does not increase the frequency of Pig-a mutant reticulocytes and erythrocytes in Sprague-Dawley rats
Autor: Bruce E. Leroy, John Nicolette, Paul Sonders, Joel Murray
Publikováno v: Environmental and Molecular Mutagenesis. 59:91-95
The in vivo rodent Pig-a mutation assay is a sensitive test to identify exposure to mutagenic substances, and has been proposed as an assay for the identification of impurities for pharmaceuticals. Red blood cells (RBCs) and reticulocytes (RETs) are
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8a6bd355ba451ed7a82eaa3323c14ef5
https://doi.org/10.1002/em.22145
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8
From the Cover: Inhibitors of Nicotinamide Phosphoribosyltransferase Cause Retinal Damage in Larval Zebrafish
Autor: Todd Cole, Natalie A Bratcher, Christina Dunn, Steven Cassar, Kenton L. Longenecker, Amanda Olson, Richard E. Peterson, Pankajkumar Sancheti, Wayne R. Buck, Stacey Fossey, Xin Huang, Bruce E. LeRoy, Heather Britton, Meg Ferrell Ramos, DeAnne Stolarik
Publikováno v: Toxicological sciences : an official journal of the Society of Toxicology. 161(2)
Nicotinamide phosphoribosyltransferase (NAMPT) has been investigated as a target for oncology because it catalyzes a rate-limiting step in cellular energy metabolism to produce nicotinamide adenine dinucleotide. Small molecule inhibitors of NAMPT hav
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5330e36c8b2fe7ff801bfd28e958e25
https://pubmed.ncbi.nlm.nih.gov/29378070
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10
Ultrastructural Analysis in Preclinical Safety Evaluation
Autor: Bruce E. LeRoy, Karamjeet Pandher, Jane A. Fagerland, Gerard D. Gagne, Henry G. Wall
Publikováno v: Toxicologic Pathology. 40:391-402
The first electron microscopic images of biological specimens were made in the 1940s, and the next 30 years comprised an era of descriptive ultrastructure during which transmission electron microscopy (TEM) was integral to an explosion in cellular an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81982b82c9a796dd05fd82bfe9204e0b
https://doi.org/10.1177/0192623311430239
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