Zobrazeno 1 - 10
of 435
pro vyhledávání: '"Bruce E Kemp"'
Publikováno v:
eLife, Vol 7 (2018)
AMP-activated protein kinase (AMPK) is a known regulator of whole-body energy homeostasis, but the downstream AMPK substrates mediating these effects are not entirely clear. AMPK inhibits fatty acid synthesis and promotes fatty acid oxidation by phos
Externí odkaz:
https://doaj.org/article/be3ecd99d63b4dea816561fddf4da4f8
Autor:
Nathaniel A. Swift, Qian Yang, Hannah M. Jester, Xueyan Zhou, Adam Manuel, Bruce E. Kemp, Gregory R. Steinberg, Tao Ma
Publikováno v:
Neurobiology of Disease, Vol 201, Iss , Pp 106664- (2024)
AMP-activated protein kinase (AMPK) is an αβγ heterotrimer protein kinase that functions as a molecular sensor to maintain energy homeostasis. Accumulating evidence suggests a role of AMPK signaling in the regulation of synaptic plasticity and cog
Externí odkaz:
https://doaj.org/article/7fa0064dd409485ab3e1e18d09af9746
Autor:
Jacqueline A Bayliss, Moyra B Lemus, Vanessa V Santos, Minh Deo, Jeffrey S Davies, Bruce E Kemp, John D Elsworth, Zane B Andrews
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159381 (2016)
Metformin is a widely prescribed drug used to treat type-2 diabetes, although recent studies show it has wide ranging effects to treat other diseases. Animal and retrospective human studies indicate that Metformin treatment is neuroprotective in Park
Externí odkaz:
https://doaj.org/article/b85dfa8a090c4b9bbecfce5a0ac911cc
Autor:
Nirma D Perera, Rebecca K Sheean, John W Scott, Bruce E Kemp, Malcolm K Horne, Bradley J Turner
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95549 (2014)
Bioenergetic abnormalities and metabolic dysfunction occur in amyotrophic lateral sclerosis (ALS) patients and genetic mouse models. However, whether metabolic dysfunction occurs early in ALS pathophysiology linked to different ALS genes remains uncl
Externí odkaz:
https://doaj.org/article/f373c34c2c154c16a02827a5b5d6a146
Autor:
Peter F Mount, Kurt Gleich, Shanna Tam, Scott A Fraser, Suet-Wan Choy, Karen M Dwyer, Bo Lu, Bryce Van Denderen, Günter Fingerle-Rowson, Richard Bucala, Bruce E Kemp, David A Power
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29887 (2012)
AIM: Activation of the master energy-regulator AMP-activated protein kinase (AMPK) in the heart reduces the severity of ischemia-reperfusion injury (IRI) but the role of AMPK in renal IRI is not known. The aim of this study was to determine whether a
Externí odkaz:
https://doaj.org/article/b4bd04c9cda345629c7322c87923a1bb
Autor:
Brittany A. Stork, Adam Dean, Andrea R. Ortiz, Pradip Saha, Nagireddy Putluri, Maricarmen D. Planas-Silva, Iqbal Mahmud, Kimal Rajapakshe, Cristian Coarfa, Stefan Knapp, Philip L. Lorenzi, Bruce E. Kemp, Benjamin E. Turk, John W. Scott, Anthony R. Means, Brian York
Publikováno v:
Molecular Metabolism, Vol 62, Iss , Pp 101513- (2022)
Objective: The liver is the primary internal metabolic organ that coordinates whole body energy homeostasis in response to feeding and fasting. Genetic ablation or pharmacological inhibition of calcium/calmodulin-dependent protein kinase kinase 2 (Ca
Externí odkaz:
https://doaj.org/article/3fe4f2f2b8c740fa9ee651656cb3b479
Autor:
Emily A. Day, Rebecca J. Ford, Brennan K. Smith, Vanessa P. Houde, Stephanie Stypa, Sonia Rehal, Sarka Lhotak, Bruce E. Kemp, Bernardo L. Trigatti, Geoff H. Werstuck, Richard C. Austin, Morgan D. Fullerton, Gregory R. Steinberg
Publikováno v:
Molecular Metabolism, Vol 53, Iss , Pp 101321- (2021)
Objective: Salsalate is a prodrug of salicylate that lowers blood glucose in people with type 2 diabetes. AMP-activated protein kinase (AMPK) is an αβγ heterotrimer which inhibits macrophage inflammation and the synthesis of fatty acids and choles
Externí odkaz:
https://doaj.org/article/ac41af7c053648d78768cda15dc2b35a
Autor:
Danuta Z. Loesch, Bruce E. Kemp, Minh Q. Bui, Paul R. Fisher, Claire Y. Allan, Oana Sanislav, Kevin R. W. Ngoei, Anna Atkinson, Flora Tassone, Sarah J. Annesley, Elsdon Storey
Publikováno v:
Frontiers in Psychiatry, Vol 12 (2021)
Fragile X Associated Tremor/Ataxia Syndrome (FXTAS) is a neurodegenerative disorder affecting carriers of premutation alleles (PM) of the X-linked FMR1 gene, which contain CGG repeat expansions of 55–200 range in a non-coding region. This late-onse
Externí odkaz:
https://doaj.org/article/ae4074102c024825816d2c1abaa6b6b0
Autor:
Vanessa P. Houde, Sara Donzelli, Andrea Sacconi, Sandra Galic, Joanne A. Hammill, Jonathan L. Bramson, Robert A. Foster, Theodoros Tsakiridis, Bruce E. Kemp, Giuseppe Grasso, Giovanni Blandino, Paola Muti, Gregory R. Steinberg
Publikováno v:
Molecular Oncology, Vol 11, Iss 9, Pp 1143-1155 (2017)
The AMP‐activated protein kinase (AMPK) is a heterotrimeric protein complex that is an important sensor of cellular energy status. Reduced expression of the AMPK β1 isoform has been linked to reduced survival in different cancers, but whether this
Externí odkaz:
https://doaj.org/article/2f7ed24678f9476889ae039ad8531ce5
Autor:
Toby A. Dite, Naomi X. Y. Ling, John W. Scott, Ashfaqul Hoque, Sandra Galic, Benjamin L. Parker, Kevin R. W. Ngoei, Christopher G. Langendorf, Matthew T. O’Brien, Mondira Kundu, Benoit Viollet, Gregory R. Steinberg, Kei Sakamoto, Bruce E. Kemp, Jonathan S. Oakhill
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
AMPK is involved in sensing of metabolic stress. The authors show that the autophagy initiator ULK1 phosphorylates β1-Ser108 on the regulatory β1-subunit, sensitizing AMPK to allosteric drugs, and activates signaling pathways that appear independen
Externí odkaz:
https://doaj.org/article/165d7eeb69bd4fda9ad259d85d17b5a6