Zobrazeno 1 - 10
of 620
pro vyhledávání: '"Bruce E Kemp"'
Autor:
Nathaniel A. Swift, Qian Yang, Hannah M. Jester, Xueyan Zhou, Adam Manuel, Bruce E. Kemp, Gregory R. Steinberg, Tao Ma
Publikováno v:
Neurobiology of Disease, Vol 201, Iss , Pp 106664- (2024)
AMP-activated protein kinase (AMPK) is an αβγ heterotrimer protein kinase that functions as a molecular sensor to maintain energy homeostasis. Accumulating evidence suggests a role of AMPK signaling in the regulation of synaptic plasticity and cog
Externí odkaz:
https://doaj.org/article/7fa0064dd409485ab3e1e18d09af9746
Autor:
Brittany A. Stork, Adam Dean, Andrea R. Ortiz, Pradip Saha, Nagireddy Putluri, Maricarmen D. Planas-Silva, Iqbal Mahmud, Kimal Rajapakshe, Cristian Coarfa, Stefan Knapp, Philip L. Lorenzi, Bruce E. Kemp, Benjamin E. Turk, John W. Scott, Anthony R. Means, Brian York
Publikováno v:
Molecular Metabolism, Vol 62, Iss , Pp 101513- (2022)
Objective: The liver is the primary internal metabolic organ that coordinates whole body energy homeostasis in response to feeding and fasting. Genetic ablation or pharmacological inhibition of calcium/calmodulin-dependent protein kinase kinase 2 (Ca
Externí odkaz:
https://doaj.org/article/3fe4f2f2b8c740fa9ee651656cb3b479
Autor:
Man K.S. Lee, Olivia D. Cooney, Xuzhu Lin, Shaktypreya Nadarajah, Dragana Dragoljevic, Kevin Huynh, Danise-Ann Onda, Sandra Galic, Peter J. Meikle, Thomas Edlund, Morgan D. Fullerton, Bruce E. Kemp, Andrew J. Murphy, Kim Loh
Publikováno v:
Molecular Metabolism, Vol 61, Iss , Pp 101514- (2022)
Objectives: Dysregulation of cholesterol metabolism in the liver and hematopoietic stem and progenitor cells (HSPCs) promotes atherosclerosis development. Previously, it has been shown that HMG-CoA-Reductase (HMGCR), the rate-limiting enzyme in the m
Externí odkaz:
https://doaj.org/article/8e3ca735c9ca4ee3934879d9b15a6a5b
Autor:
Natalie R. Janzen, Jamie Whitfield, Lisa Murray-Segal, Bruce E. Kemp, John A. Hawley, Nolan J. Hoffman
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
The AMP-activated protein kinase (AMPK) is a central regulator of cellular energy balance and metabolism and binds glycogen, the primary storage form of glucose in liver and skeletal muscle. The effects of disrupting whole-body AMPK-glycogen interact
Externí odkaz:
https://doaj.org/article/e253ca0f9f6143b8b3755cdb3ed0c4b8
Autor:
Emily A. Day, Rebecca J. Ford, Brennan K. Smith, Vanessa P. Houde, Stephanie Stypa, Sonia Rehal, Sarka Lhotak, Bruce E. Kemp, Bernardo L. Trigatti, Geoff H. Werstuck, Richard C. Austin, Morgan D. Fullerton, Gregory R. Steinberg
Publikováno v:
Molecular Metabolism, Vol 53, Iss , Pp 101321- (2021)
Objective: Salsalate is a prodrug of salicylate that lowers blood glucose in people with type 2 diabetes. AMP-activated protein kinase (AMPK) is an αβγ heterotrimer which inhibits macrophage inflammation and the synthesis of fatty acids and choles
Externí odkaz:
https://doaj.org/article/ac41af7c053648d78768cda15dc2b35a
Autor:
Danuta Z. Loesch, Bruce E. Kemp, Minh Q. Bui, Paul R. Fisher, Claire Y. Allan, Oana Sanislav, Kevin R. W. Ngoei, Anna Atkinson, Flora Tassone, Sarah J. Annesley, Elsdon Storey
Publikováno v:
Frontiers in Psychiatry, Vol 12 (2021)
Fragile X Associated Tremor/Ataxia Syndrome (FXTAS) is a neurodegenerative disorder affecting carriers of premutation alleles (PM) of the X-linked FMR1 gene, which contain CGG repeat expansions of 55–200 range in a non-coding region. This late-onse
Externí odkaz:
https://doaj.org/article/ae4074102c024825816d2c1abaa6b6b0
Autor:
Nolan J. Hoffman, Jamie Whitfield, Natalie R. Janzen, Mehdi R. Belhaj, Sandra Galic, Lisa Murray-Segal, William J. Smiles, Naomi X.Y. Ling, Toby A. Dite, John W. Scott, Jonathan S. Oakhill, Robert Brink, Bruce E. Kemp, John A. Hawley
Publikováno v:
Molecular Metabolism, Vol 41, Iss , Pp 101048- (2020)
Objective: Glycogen is a major energy reserve in liver and skeletal muscle. The master metabolic regulator AMP-activated protein kinase (AMPK) associates with glycogen via its regulatory β subunit carbohydrate-binding module (CBM). However, the phys
Externí odkaz:
https://doaj.org/article/87aacaf855cb400a99375db49d1f3201
Autor:
Vanessa P. Houde, Sara Donzelli, Andrea Sacconi, Sandra Galic, Joanne A. Hammill, Jonathan L. Bramson, Robert A. Foster, Theodoros Tsakiridis, Bruce E. Kemp, Giuseppe Grasso, Giovanni Blandino, Paola Muti, Gregory R. Steinberg
Publikováno v:
Molecular Oncology, Vol 11, Iss 9, Pp 1143-1155 (2017)
The AMP‐activated protein kinase (AMPK) is a heterotrimeric protein complex that is an important sensor of cellular energy status. Reduced expression of the AMPK β1 isoform has been linked to reduced survival in different cancers, but whether this
Externí odkaz:
https://doaj.org/article/2f7ed24678f9476889ae039ad8531ce5
Autor:
Toby A. Dite, Naomi X. Y. Ling, John W. Scott, Ashfaqul Hoque, Sandra Galic, Benjamin L. Parker, Kevin R. W. Ngoei, Christopher G. Langendorf, Matthew T. O’Brien, Mondira Kundu, Benoit Viollet, Gregory R. Steinberg, Kei Sakamoto, Bruce E. Kemp, Jonathan S. Oakhill
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
AMPK is involved in sensing of metabolic stress. The authors show that the autophagy initiator ULK1 phosphorylates β1-Ser108 on the regulatory β1-subunit, sensitizing AMPK to allosteric drugs, and activates signaling pathways that appear independen
Externí odkaz:
https://doaj.org/article/165d7eeb69bd4fda9ad259d85d17b5a6
Autor:
Sarah J. Annesley, Sui T. Lay, Shawn W. De Piazza, Oana Sanislav, Eleanor Hammersley, Claire Y. Allan, Lisa M. Francione, Minh Q. Bui, Zhi-Ping Chen, Kevin R. W. Ngoei, Flora Tassone, Bruce E. Kemp, Elsdon Storey, Andrew Evans, Danuta Z. Loesch, Paul R. Fisher
Publikováno v:
Disease Models & Mechanisms, Vol 9, Iss 11, Pp 1295-1305 (2016)
In combination with studies of post-mortem Parkinson's disease (PD) brains, pharmacological and genetic models of PD have suggested that two fundamental interacting cellular processes are impaired – proteostasis and mitochondrial respiration. We ha
Externí odkaz:
https://doaj.org/article/96d199417b6546faba92ecd66b2679dc