Výsledky vyhledávání - "Bruce E Dornseif"

A proposed approach for analyzing post-study therapy effect in survival analysis

Autor: Bruce E. Dornseif, Mingyu Li, Qiang Xu, Gary G. Koch, Guang Chen, Xiaolong Luo, Markus F. Renschler, Chengqing Wu

Publikováno v: Journal of Biopharmaceutical Statistics. 26:790-800

Clinical trials that explore long-term endpoints may confound the analysis when post-study therapy effects are considered. This article introduces a procedure to mediate the effects of confounding and allow inferences of first-line experimental treat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8196a403d26cb2072a135707102f16a
https://doi.org/10.1080/10543406.2015.1074916

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Predicting analysis time in events-driven clinical trials using accumulating time-to-event surrogate information

Autor: Chunlei Ke, Bruce E. Dornseif, Zhinuan Yu, Jianming Wang, Lei Fu

Publikováno v: Pharmaceutical Statistics. 15:198-207

For clinical trials with time-to-event endpoints, predicting the accrual of the events of interest with precision is critical in determining the timing of interim and final analyses. For example, overall survival (OS) is often chosen as the primary e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a2ce401cdf6b0d9611f98d0d14965975
https://doi.org/10.1002/pst.1732

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Modelling and simulation of edoxaban exposure and response relationships in patients with atrial fibrillation

Autor: Robert P. Giugliano, Helen Kastrissios, Tomas S. Bocanegra, Simon Zhou, Michelle Green, Shashank Rohatagi, Indravadan Patel, Timothy J. Carrothers, Bruce E Dornseif, SaeHeum Song, Satoshi Kunitada, Minggao Shi, Jeanne Mendell, Daniel E. Salazar, Elliott M. Antman, Masaya Tachibana

Publikováno v: Thrombosis and Haemostasis. 107:925-934

SummaryEdoxaban is a novel, orally available, highly specific direct inhibitor of factor Xa and is currently being developed for the treatment and prevention of venous thromboembolism and prevention of stroke and systemic embolism in patients with no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1257db9dae2118086028e4446bbb590
https://doi.org/10.1160/th11-08-0566

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A proposed statistical framework for the management of subgroup analyses for large clinical trials

Autor: Guang Chen, Xiaolong Luo, Gary A. Cline, Zhezhen Jin, Qian Dong, Bruce E. Dornseif, Alan Chengqing Wu, Guohua Pan, Peng Chen, Mingyu Li

Publikováno v: Contemporary clinical trials. 45

Planned and unplanned subgroup analyses of large clinical trials are frequently performed and the results are sometimes difficult to interpret. The source of a nominal significant finding may come from a true signal, variation of the clinical trial o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6080e5425ef8a24876c94d0228e5327
https://pubmed.ncbi.nlm.nih.gov/26388115

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Dose Conversion and Titration with a Novel, Once-Daily, OROS® Osmotic Technology, Extended-Release Hydromorphone Formulation in the Treatment of Chronic Malignant or Nonmalignant Pain

Autor: Bruce E. Dornseif, Donald W. Northfelt, Russell K. Portenoy, Mark Palangio, Daniel Brookoff, Michael C Damask, Ralph T. Doyle

Publikováno v: Journal of Pain and Symptom Management. 23:355-368

The objective of this open-label, repeated-dose, single-treatment, multicenter study was to evaluate the outcomes associated with a standardized conversion from prior opioid therapy to a novel, once-daily, OROS osmotic technology, extended-release (E

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e254aabfdbac2121550682a731f0ab61
https://doi.org/10.1016/s0885-3924(02)00390-1

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Fluoxetine Not Associated With Increased Violence or Aggression in Controlled Clinical Trials

Autor: John H. Heiligenstein, Daniel N. Masica, Janet H. Potvin, Emil F. Coccaro, Bruce E. Dornseif, Charles M. Beasley

Publikováno v: Annals of Clinical Psychiatry. 4:285-295

Because of interest in the possible occurrence of violent 01 aggressive behavior with serotonin-enhancing drugs, three subpools of controlled clinical trial data were evaluated: fluoxetine (n = 2615) versus placebo (n = 1377) (18 trials; depression,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::18c9b9148cb1719a6a1c51ebdd490a1c
https://doi.org/10.3109/10401239209150461

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Fluoxetine and Suicide

Autor: Vicki L. Thompson, John H. Heiligenstein, Daniel N. Masica, Charles M. Beasley, Alvin H. Rampey, Janet C. Bosomworth, Mary E. Sayler, Bruce E. Dornseif, Dennis J. Murphy

Publikováno v: International Clinical Psychopharmacology. 6:35-57

OBJECTIVE--A comprehensive meta-analysis of clinical trial data was performed to assess the possible association of fluoxetine and suicidality (suicidal acts and ideation). DESIGN--Retrospective analysis of pooled data from 17 double blind clinical t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8a4af49316fbc5306cb2b82099504a5
https://doi.org/10.1097/00004850-199206006-00006

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Fluoxetine: no association with suicidality in obsessive-compulsive disorder

Autor: Charles M. Beasley, Janet H. Potvin, Laura A. Genduso, David E. Wheadon, Daniel N. Masica, Bruce E. Dornseif

Publikováno v: Journal of Affective Disorders. 24:1-10

Since (a) obsessive-compulsive disorder (OCD) may involve serotonergic neural transmission abnormalities also thought to be related to regulation of suicide and aggression, (b) comorbidity between OCD and depression is substantial, and (c) depression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f4e9608d0b0b3ef576629a0e46a65e6
https://doi.org/10.1016/0165-0327(92)90054-a

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