Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Bruce E Clurman"'
Autor:
H Nayanga Thirimanne, Feinan Wu, Derek H Janssens, Jherek Swanger, Ahmed Diab, Heather M Feldman, Robert A Amezquita, Raphael Gottardo, Patrick J Paddison, Steven Henikoff, Bruce E Clurman
Publikováno v:
eLife, Vol 11 (2022)
The Fbw7 ubiquitin ligase targets many proteins for proteasomal degradation, which include oncogenic transcription factors (TFs) (e.g., c-Myc, c-Jun, and Notch). Fbw7 is a tumor suppressor and tumors often contain mutations in FBXW7, the gene that en
Externí odkaz:
https://doaj.org/article/04134ed54862435e8033d1ac577697c2
Publikováno v:
PLoS Pathogens, Vol 15, Iss 1, p e1007543 (2019)
Merkel cell polyomavirus (MCPyV) accounts for 80% of all Merkel cell carcinoma (MCC) cases through expression of two viral oncoproteins: the truncated large T antigen (LT-t) and small T antigen (ST). MCPyV ST is thought to be the main driver of cellu
Externí odkaz:
https://doaj.org/article/4f1b05a618834a218d950755a744d4d6
Publikováno v:
PLoS Biology, Vol 11, Iss 6, p e1001586 (2013)
FBW7 is a crucial component of an SCF-type E3 ubiquitin ligase, which mediates degradation of an array of different target proteins. The Fbw7 locus comprises three different isoforms, each with its own promoter and each suspected to have a distinct s
Externí odkaz:
https://doaj.org/article/f5fb39c356274714acdaf7ed508dfa86
Autor:
Daniel A Kuppers, Harry C Hwang, Aimee L Jackson, Peter S Linsley, Bruce E Clurman, Matthew L Fero
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e14758 (2011)
Mice lacking the p27(Kip1) Cdk inhibitor (Cdkn1b) exhibit increased susceptibility to lymphomas from the Maloney murine leukemia virus (M-MuLV), and exhibit a high frequency of viral integrations at Xpcl1 (Kis2), a locus on the X-chromosome. Xpcl1 en
Externí odkaz:
https://doaj.org/article/d72def821bff4b12b228cd374b202ed2
Autor:
Carrie M Garrett-Engele, Michael A Tasch, Harry C Hwang, Matthew L Fero, Roger M Perlmutter, Bruce E Clurman, James M Roberts
Publikováno v:
PLoS Genetics, Vol 3, Iss 12, p e219 (2007)
The cyclin-dependent kinase inhibitor p27(KIP1) is a tumor suppressor gene in mice, and loss of p27 protein is a negative prognostic indicator in human cancers. Unlike other tumor suppressors, the p27 gene is rarely mutated in tumors. Therefore misre
Externí odkaz:
https://doaj.org/article/3c113f238bd94d4da9eb5f2d05bb5853
Autor:
Kripa S. Keyan, Jorge Almagro, Bruce E. Clurman, Ambrosius P. Snijders, Stuart Horswell, Vesela Encheva, Jessica K. Nelson, Axel Behrens, Omar M. Khan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications
The tumour suppressor FBW7 is a substrate adaptor for the E3 ubiquitin ligase complex SKP1-CUL1-F-box (SCF), that targets several oncoproteins for proteasomal degradation. FBW7 is widely mutated and FBW7 protein levels are commonly downregulated in c
Autor:
Jherek Swanger, Eduardo Mendez, Keith R. Loeb, Hee Yeon Kim, Matthew Fitzgibbon, Ahmed Diab, Kaleb Smith, Hakan Gem, Bruce E. Clurman, Grace Zou, Michael Kao, Sharat Raju, Cristina P. Rodriguez, Julia M. Sidorova, Denise A. Galloway
Publikováno v:
Proc Natl Acad Sci U S A
Head and neck squamous cell carcinoma (HNSCC) associated with high-risk human papilloma virus (HPV) infection is a growing clinical problem. The WEE1 kinase inhibitor AZD1775 (WEE1i) overrides cell cycle checkpoints and is being studied in HNSCC regi
Autor:
H Nayanga Thirimanne, Feinan Wu, Derek H Janssens, Jherek Swanger, Ahmed Diab, Heather M Feldman, Robert A Amezquita, Raphael Gottardo, Patrick J Paddison, Steven Henikoff, Bruce E Clurman
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::557304f0d5b22ba5324ef50a540c5e00
https://doi.org/10.7554/elife.74338.sa2
https://doi.org/10.7554/elife.74338.sa2
Autor:
Markus Welcker, Baiyun Wang, Domniţa-Valeria Rusnac, Yasser Hussaini, Jherek Swanger, Ning Zheng, Bruce E. Clurman
Publikováno v:
Science Advances. 8
c-Myc (hereafter, Myc) is a cancer driver whose abundance is regulated by the SCF Fbw7 ubiquitin ligase and proteasomal degradation. Fbw7 binds to a phosphorylated Myc degron centered at threonine 58 (T58), and mutations of Fbw7 or T58 impair Myc deg
Autor:
Raphael Gottardo, Bruce E. Clurman, Feinan Wu, Patrick J. Paddison, H. Nayanga Thirimanne, Robert A. Amezquita, Jherek Swanger, Heather Feldman, Derek H. Janssens, Steven Henikoff
Fbw7 is a ubiquitin ligase substrate receptor that targets proteins for proteasomal degradation. Most known Fbw7 substrates are transcription factors (TFs) and many are also oncoproteins (e.g., c-Myc, c-Jun, Notch). Fbw7 is an important tumor suppres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2aee674b1a69a3cd3cbfe81f73f1b2d6
https://doi.org/10.1101/2021.10.19.464955
https://doi.org/10.1101/2021.10.19.464955