Zobrazeno 1 - 10
of 180
pro vyhledávání: '"Bruce E Clurman"'
Autor:
Omar M. Khan, Jorge Almagro, Jessica K. Nelson, Stuart Horswell, Vesela Encheva, Kripa S. Keyan, Bruce E. Clurman, Ambrosius P. Snijders, Axel Behrens
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
The tumor suppressor FBW7 is a substrate adaptor for the E3 ubiquitin ligase complex SKP1-CUL1-F-box (SCF) and itself a target for ubiquitylation. Here, the authors show that TRIP12 mediates branched K11-linked ubiquitylation of FBW7, to regulate its
Externí odkaz:
https://doaj.org/article/6e27448b8929476da30da600acc41eb2
Autor:
H Nayanga Thirimanne, Feinan Wu, Derek H Janssens, Jherek Swanger, Ahmed Diab, Heather M Feldman, Robert A Amezquita, Raphael Gottardo, Patrick J Paddison, Steven Henikoff, Bruce E Clurman
Publikováno v:
eLife, Vol 11 (2022)
The Fbw7 ubiquitin ligase targets many proteins for proteasomal degradation, which include oncogenic transcription factors (TFs) (e.g., c-Myc, c-Jun, and Notch). Fbw7 is a tumor suppressor and tumors often contain mutations in FBXW7, the gene that en
Externí odkaz:
https://doaj.org/article/04134ed54862435e8033d1ac577697c2
Autor:
Nadish Goyal, Matthew J. Rossi, Olga M. Mazina, Yong Chi, Robert L. Moritz, Bruce E. Clurman, Alexander V. Mazin
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
RAD54 stimulates activity of the RAD51 recombinase and catalyzes branch migration of Holliday junctions during DNA repair and recombination. Here the authors show that the N-terminal domain of RAD54 mediates RAD54 oligomerization to promote branch mi
Externí odkaz:
https://doaj.org/article/b15bd6aeba5249c9abdcd8a19d96755d
Autor:
Philamer C. Calses, Kiranjit K. Dhillon, Nyka Tucker, Yong Chi, Jen-wei Huang, Masaoki Kawasumi, Paul Nghiem, Yemin Wang, Bruce E. Clurman, Celine Jacquemont, Philip R. Gafken, Kaoru Sugasawa, Masafumi Saijo, Toshiyasu Taniguchi
Publikováno v:
Cell Reports, Vol 19, Iss 1, Pp 162-174 (2017)
Ultraviolet (UV) radiation is a carcinogen that generates DNA lesions. Here, we demonstrate an unexpected role for DGCR8, an RNA binding protein that canonically functions with Drosha to mediate microRNA processing, in the repair of UV-induced DNA le
Externí odkaz:
https://doaj.org/article/d2a0ebcac7f646e3b21efe404b0f2b3c
Publikováno v:
PLoS Pathogens, Vol 15, Iss 1, p e1007543 (2019)
Merkel cell polyomavirus (MCPyV) accounts for 80% of all Merkel cell carcinoma (MCC) cases through expression of two viral oncoproteins: the truncated large T antigen (LT-t) and small T antigen (ST). MCPyV ST is thought to be the main driver of cellu
Externí odkaz:
https://doaj.org/article/4f1b05a618834a218d950755a744d4d6
Autor:
Chad M. Toledo, Yu Ding, Pia Hoellerbauer, Ryan J. Davis, Ryan Basom, Emily J. Girard, Eunjee Lee, Philip Corrin, Traver Hart, Hamid Bolouri, Jerry Davison, Qing Zhang, Justin Hardcastle, Bruce J. Aronow, Christopher L. Plaisier, Nitin S. Baliga, Jason Moffat, Qi Lin, Xiao-Nan Li, Do-Hyun Nam, Jeongwu Lee, Steven M. Pollard, Jun Zhu, Jeffery J. Delrow, Bruce E. Clurman, James M. Olson, Patrick J. Paddison
Publikováno v:
Cell Reports, Vol 13, Iss 11, Pp 2425-2439 (2015)
To identify therapeutic targets for glioblastoma (GBM), we performed genome-wide CRISPR-Cas9 knockout (KO) screens in patient-derived GBM stem-like cells (GSCs) and human neural stem/progenitors (NSCs), non-neoplastic stem cell controls, for genes re
Externí odkaz:
https://doaj.org/article/5e9fe4212e494c438694a02840440074
Autor:
Kripa S. Keyan, Jorge Almagro, Bruce E. Clurman, Ambrosius P. Snijders, Stuart Horswell, Vesela Encheva, Jessica K. Nelson, Axel Behrens, Omar M. Khan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications
The tumour suppressor FBW7 is a substrate adaptor for the E3 ubiquitin ligase complex SKP1-CUL1-F-box (SCF), that targets several oncoproteins for proteasomal degradation. FBW7 is widely mutated and FBW7 protein levels are commonly downregulated in c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52317b9d43255e960ff3720013d3922f
https://doaj.org/article/6e27448b8929476da30da600acc41eb2
https://doaj.org/article/6e27448b8929476da30da600acc41eb2
Autor:
Jherek Swanger, Eduardo Mendez, Keith R. Loeb, Hee Yeon Kim, Matthew Fitzgibbon, Ahmed Diab, Kaleb Smith, Hakan Gem, Bruce E. Clurman, Grace Zou, Michael Kao, Sharat Raju, Cristina P. Rodriguez, Julia M. Sidorova, Denise A. Galloway
Publikováno v:
Proc Natl Acad Sci U S A
Head and neck squamous cell carcinoma (HNSCC) associated with high-risk human papilloma virus (HPV) infection is a growing clinical problem. The WEE1 kinase inhibitor AZD1775 (WEE1i) overrides cell cycle checkpoints and is being studied in HNSCC regi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7366847be1a373a516b26872d55e6833
https://doi.org/10.1073/pnas.2013921117
https://doi.org/10.1073/pnas.2013921117
Autor:
H Nayanga Thirimanne, Feinan Wu, Derek H Janssens, Jherek Swanger, Ahmed Diab, Heather M Feldman, Robert A Amezquita, Raphael Gottardo, Patrick J Paddison, Steven Henikoff, Bruce E Clurman
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::557304f0d5b22ba5324ef50a540c5e00
https://doi.org/10.7554/elife.74338.sa2
https://doi.org/10.7554/elife.74338.sa2
Autor:
Markus Welcker, Baiyun Wang, Domniţa-Valeria Rusnac, Yasser Hussaini, Jherek Swanger, Ning Zheng, Bruce E. Clurman
Publikováno v:
Science Advances. 8
c-Myc (hereafter, Myc) is a cancer driver whose abundance is regulated by the SCF Fbw7 ubiquitin ligase and proteasomal degradation. Fbw7 binds to a phosphorylated Myc degron centered at threonine 58 (T58), and mutations of Fbw7 or T58 impair Myc deg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc5878e753c8b045be8b069d870fe2f8
https://doi.org/10.1126/sciadv.abl7872
https://doi.org/10.1126/sciadv.abl7872