Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Bruce E, Tomczuk"'
Autor:
Christopher J. Molloy, Bruce E. Tomczuk, Danielle Lawrence, Christian Baumann, Heidi Ott, Shelley K. Ballentine, Jinsheng Chen, Mark J. Wall, Kenneth J. Wilson, Sanath K. Meegalla, Lisa Boczon, Edward J. Yurkow, Yanmin Chen, Carl Crysler, Lee Zeng, Carol F. Franks, Robert R. Donatelli, Margery A. Chaikin, Judith F. Baker, Zhao Zhou, Robert W. Tuman, Carl R. Illig, Dana L. Johnson, Carl L. Manthey
Supplementary Figure 1, Tables 1-4 from JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb53737462ca7c21b088c7e98afca976
https://doi.org/10.1158/1535-7163.22485255.v1
https://doi.org/10.1158/1535-7163.22485255.v1
Autor:
Christopher J. Molloy, Bruce E. Tomczuk, Danielle Lawrence, Christian Baumann, Heidi Ott, Shelley K. Ballentine, Jinsheng Chen, Mark J. Wall, Kenneth J. Wilson, Sanath K. Meegalla, Lisa Boczon, Edward J. Yurkow, Yanmin Chen, Carl Crysler, Lee Zeng, Carol F. Franks, Robert R. Donatelli, Margery A. Chaikin, Judith F. Baker, Zhao Zhou, Robert W. Tuman, Carl R. Illig, Dana L. Johnson, Carl L. Manthey
There is increasing evidence that tumor-associated macrophages promote the malignancy of some cancers. Colony-stimulating factor-1 (CSF-1) is expressed by many tumors and is a growth factor for macrophages and mediates osteoclast differentiation. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da7c495ed76df00defda047352171a57
https://doi.org/10.1158/1535-7163.c.6531858.v1
https://doi.org/10.1158/1535-7163.c.6531858.v1
Autor:
Jeremy M. Travins, Carl Crysler, Hufnagel Heather Rae, Karen DiLoreto, Norman Huebert, Michael X. Kolpak, Nalin L. Subasinghe, Jennifer Kirkpatrick, Stephen H. Eisennagel, Bruce E. Tomczuk, Wenxi Pan, Christopher J. Molloy, Ehab Khalil, Nisha S. Ninan, Shelley K. Ballentine, Kristi A. Leonard, Roger F. Bone, Richard Soll, Farah Ali, Michael D. Gaul
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:5303-5307
Complement C1s protease inhibitors have potential utility in the treatment of diseases associated with activation of the classical complement pathway such as humorally mediated graft rejection, ischemia-reperfusion injury (IRI), vascular leak syndrom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44891a19d07c75d5617cf44b0ba3e337
https://doi.org/10.1016/j.bmcl.2012.06.030
https://doi.org/10.1016/j.bmcl.2012.06.030
Autor:
Christopher J. Molloy, Shelley K. Ballentine, Edward J. Yurkow, Carsten Schubert, Carl Crysler, Renee L. DesJarlais, Yanmin Chen, Sanath K. Meegalla, Carl L. Manthey, Mark J. Wall, Bruce E. Tomczuk, Carl R. Illig, Zhao Zhou, Jinsheng Chen, Kenneth J. Wilson, Mark R. Player, Robert R. Donatelli, Margery A. Chaikin
Publikováno v:
Journal of Medicinal Chemistry. 54:7860-7883
A class of potent inhibitors of colony-stimulating factor-1 receptor (CSF-1R or FMS), as exemplified by 8 and 21, was optimized to improve pharmacokinetic and pharmacodynamic properties and potential toxicological liabilities. Early stage absorption,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dea3adaebd4f6f20559806e92e11896f
https://doi.org/10.1021/jm200900q
https://doi.org/10.1021/jm200900q
Autor:
Danielle Lawrence, Yanmin Chen, Mark J. Wall, Carl L. Manthey, Christopher J. Molloy, Edward J. Yurkow, Kenneth J. Wilson, Sanath K. Meegalla, Dana L. Johnson, Carol F. Franks, Bruce E. Tomczuk, Lee Zeng, Shelley K. Ballentine, Baumann Christian Andrew, Zhao Zhou, Judith Baker, Robert R. Donatelli, Lisa Boczon, Carl Crysler, Carl R. Illig, Heidi Ott, Jinsheng Chen, Tuman Robert W, Margery A. Chaikin
Publikováno v:
Molecular Cancer Therapeutics. 8:3151-3161
There is increasing evidence that tumor-associated macrophages promote the malignancy of some cancers. Colony-stimulating factor-1 (CSF-1) is expressed by many tumors and is a growth factor for macrophages and mediates osteoclast differentiation. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a1dcd64b489777dd1393ee065709ba7
https://doi.org/10.1158/1535-7163.mct-09-0255
https://doi.org/10.1158/1535-7163.mct-09-0255
Autor:
Yanmin Chen, Christopher J. Molloy, Carl R. Illig, Margery A. Chaikin, Carl L. Manthey, Renee L. DesJarlais, Carl Crysler, Carsten Schubert, Sanath K. Meegalla, Mark R. Player, Jinsheng Chen, Shelley K. Ballentine, Bruce E. Tomczuk, Mark J. Wall, Kenneth J. Wilson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:3632-3637
An anti-inflammatory 1,2,4-phenylenetriamine-containing series of FMS inhibitors with a potential to form reactive metabolites was transformed into a series with equivalent potency by incorporation of carbon-based replacement groups. Structure-based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae7fedad7a5539d69102e1d1474ac077
https://doi.org/10.1016/j.bmcl.2008.04.059
https://doi.org/10.1016/j.bmcl.2008.04.059
Autor:
Renee L. DesJarlais, Carl R. Illig, Shelley K. Ballentine, Margery A. Chaikin, M. Jonathan Rudolph, Carsten Schubert, Kenneth J. Wilson, Bruce E. Tomczuk, Jinsheng Chen, Mark R. Player, Ioanna Petrounia, Mark J. Wall, Christopher J. Molloy, Yanmin Chen, Sanath K. Meegalla, Carl Crysler, Carl L. Manthey
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:1642-1648
The optimization of the arylamide lead 2 resulted in identification of a highly potent series of 2,4-disubstituted arylamides. Compound 8 (FMS kinase IC(50)=0.0008 microM) served as a proof-of-concept candidate in a collagen-induced model of arthriti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bc7fcf0d95c0b945a2cac5006d4cedc
https://doi.org/10.1016/j.bmcl.2008.01.059
https://doi.org/10.1016/j.bmcl.2008.01.059
Autor:
Renee L. DesJarlais, Hui Huang, Jennifer Kirkpatrick, Nalin L. Subasinghe, Norman Huebert, Gaul Michael David, Nisha S. Ninan, Joan Gushue, Jeremy M. Travins, Bruce E. Tomczuk, Roger F. Bone, Shelley K. Ballentine, Christopher J. Molloy, Kristi A. Leonard, Ehab Khalil, Hufnagel Heather Rae, Farah Ali, Maxwell D. Cummings, Richard M. Soll, Wenxi Pan, Carl Crysler
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:1603-1606
Complement activation has been implicated in disease states such as hereditary angioedema, ischemia-reperfusion injury, acute respiratory distress syndrome, and acute transplant rejection. Even though the complement cascade provides several protein t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06eefcfefc962ecd7776e95a4980fdd8
https://doi.org/10.1016/j.bmcl.2008.01.064
https://doi.org/10.1016/j.bmcl.2008.01.064
Autor:
Jinsheng Chen, Carl L. Manthey, Kenneth J. Wilson, Marie Mazzulla, Margery A. Chaikin, Christopher J. Molloy, Bruce E. Tomczuk, Edward J. Yurkow, Shelley K. Ballentine, Carsten Schubert, Carl Crysler, Renee L. DesJarlais, Ioanna Petrounia, Robert R. Donatelli, Carl R. Illig, Lisa Boczon, Sanath K. Meegalla, Mark J. Wall, Raymond J. Patch, Mark R. Player
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:2097-2102
A series of 3,4,6-substituted 2-quinolones has been synthesized and evaluated as inhibitors of the kinase domain of macrophage colony-stimulating factor-1 receptor (FMS). The fully optimized compound, 4-(4-ethyl-phenyl)-3-(2-methyl-3H-imidazol-4-yl)-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8176b1c0c69b0ad2c4b2f6486901881a
https://doi.org/10.1016/j.bmcl.2008.01.088
https://doi.org/10.1016/j.bmcl.2008.01.088
Autor:
Yanmin Chen, Stephen H. Eisennagel, Cesar Tio, Norman Huebert, Natashia Kagan, Deping Cheng, Bruce E. Tomczuk, Roger F. Bone, Malini Dasgupta
Publikováno v:
Biopharmaceutics & Drug Disposition. 29:127-138
The pharmacokinetics of TDP4815 was evaluated in rats, rabbits, dogs and monkeys. After intravenous administration, TDP4815 achieved CO of 3255 ng/ml in rats at 5 mg/kg, 9066 ng/ml in rabbits and 7858 ng/ml in monkeys at 6 mg/kg, and 4457 ng/ml in do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a26d5e02f87abce37699357a3fb6a441
https://doi.org/10.1002/bdd.592
https://doi.org/10.1002/bdd.592