Zobrazeno 1 - 10
of 189
pro vyhledávání: '"Bruce Demple"'
Autor:
Rachel A. Caston, Paola Fortini, Kevin Chen, Jack Bauer, Eugenia Dogliotti, Y. Whitney Yin, Bruce Demple
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 16, p 12715 (2023)
After cellular differentiation, nuclear DNA is no longer replicated, and many of the associated proteins are downregulated accordingly. These include the structure-specific endonucleases Fen1 and DNA2, which are implicated in repairing mitochondrial
Externí odkaz:
https://doaj.org/article/aabe021fbe59425c8c45609903af5d6d
Autor:
Zhouyiyuan Xue, Bruce Demple
Publikováno v:
Antioxidants, Vol 11, Iss 9, p 1817 (2022)
Apurinic/apyrimidinic endonuclease 1/redox effector-1 (Ape1/Ref-1) is the major apurinic/apyrimidinic (AP) endonuclease in mammalian cells. It functions mainly in the base excision repair pathway to create a suitable substrate for DNA polymerases. Hu
Externí odkaz:
https://doaj.org/article/abf01df0d54c4813887ad5872223941e
Publikováno v:
GeoHealth, Vol 2, Iss 4, Pp 139-148 (2018)
Abstract Previous missions to the lunar surface implicated potential dangers of lunar soil. In future explorations, astronauts may spend weeks or months on the Moon, increasing the risk of inhaling lunar dust. In an effort to understand the biologica
Externí odkaz:
https://doaj.org/article/6c5a5468061d4b21b0ca7435a6f9b14d
Autor:
Upasna Thapar, Bruce Demple
Publikováno v:
F1000Research, Vol 6 (2017)
Since the discovery of the base excision repair (BER) system for DNA more than 40 years ago, new branches of the pathway have been revealed at the biochemical level by in vitro studies. Largely for technical reasons, however, the confirmation of thes
Externí odkaz:
https://doaj.org/article/685c4e8c2a5d445da8d520e4ff1497d8
Publikováno v:
Toxics, Vol 6, Iss 3, p 35 (2018)
There is growing evidence of immunotoxicity related to exposure to toxic trace metals, and an examination of gene expression patterns in peripheral blood samples may provide insights into the potential development of these outcomes. This pilot study
Externí odkaz:
https://doaj.org/article/b48320a74fe4424ab03684db742b12ba
Autor:
M A Suresh Kumar, Michael Peluso, Pankaj Chaudhary, Jasbeer Dhawan, Afshin Beheshti, Krishnan Manickam, Upasna Thapar, Louis Pena, Mohan Natarajan, Lynn Hlatky, Bruce Demple, Mamta Naidu
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0133016 (2015)
Ionizing radiation causes degeneration of myelin, the insulating sheaths of neuronal axons, leading to neurological impairment. As radiation research on the central nervous system has predominantly focused on neurons, with few studies addressing the
Externí odkaz:
https://doaj.org/article/ae1ff896d5704cbc9df3625b2c011e2b
Autor:
Jamie Hsing-Ming Chang, Zhouyiyuan Xue, Jack Bauer, Barbara Wehle, Donald A Hendrix, Tristan Catalano, Joel A. Hurowitz, Hanna Nekvasil, Bruce Demple
During NASA’s Apollo missions, inhalation of dust particles from lunar regolith was identified as a potential occupational hazard for astronauts. These fine particles adhered tightly to spacesuits and were brought accidentally into the living areas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4adfd780ebdc48dd0dbea800a05fc7b3
https://doi.org/10.22541/essoar.168275926.64453531/v1
https://doi.org/10.22541/essoar.168275926.64453531/v1
Autor:
Bruce Demple, Upasna Thapar
Publikováno v:
DNA Repair. 76:11-19
There exist two major base excision DNA repair (BER) pathways, namely single-nucleotide or “short-patch” (SP-BER), and “long-patch” BER (LP-BER). Both pathways appear to be involved in the repair of small base lesions such as uracil, abasic s
Autor:
Upasna Thapar, Bruce Demple
Publikováno v:
Encyclopedia of Biological Chemistry III ISBN: 9780128220405
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8015e6fb6300d13f7222e229d4dc9ccd
https://doi.org/10.1016/b978-0-12-819460-7.00247-4
https://doi.org/10.1016/b978-0-12-819460-7.00247-4
Autor:
Daniela Marasco, Antonella Virgilio, Aldo Galeone, Gianluca Tell, Giulia Antoniali, Silvia Burra, Veronica Esposito, Matilde Clarissa Malfatti, Bruce Demple
Loss of telomeres stability is a hallmark of cancer cells. Exposed telomeres are prone to aberrant end-joining reactions leading to chromosomal fusions and translocations. Human telomeres contain repeated TTAGGG elements, in which the 3′ exposed st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3eee47fbd2da7ea31408035ee34a5a9
http://hdl.handle.net/11390/1147642
http://hdl.handle.net/11390/1147642