Mutation of KCNK5 or Kir3.2 Potassium Channels in Mice Does Not Change Minimum Alveolar Anesthetic Concentration

Autor: Diane H. Gong, Bruce D. Winegar, Edmond I. Eger, Karin M. Gerstin, Mona Abdallah, Andrew T. Gray

Publikováno v: Anesthesia & Analgesia. :1345-1349

Several reports suggest that clinically used concentrations of inhaled anesthetics can increase conductance through noninactivating potassium channels and that the resulting hyperpolarization might decrease excitability, thereby leading to the anesth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faa608b0e66eb507869e683e24d57ce7
https://doi.org/10.1213/01.ane.0000056921.15974.ec

Abstract

Autor: Douglas D. Snider, Brendan T. Finucane, Donna Clarke, J. Loiselle, G. Doak, B. Anderson, Dan Wood, Sandy Shysh, Michel-Antoine Perrault, Philippe Chouinard, François Fugère, François Girard, Monique Ruel, Wendy C. E. Hall, Jiri Hrazdil, Donald T. Jolly, John C. Galbraith, Maria C. Greacen, Alexander S. Clanachan, Duminda N. Wijeysundera, W. Scott Beattie, Michelle Chochinov, Stephen Halpern, Dolores M. McKeen, Robert T. Nunn, Brendan S. Barrett, G. Allen Finley, Susan Buffett-Jerrott, Sherry Stewart, Donna Millington, Keyvan Karkouti, Yoga R. Rampersaud, Stuart A. McCluskey, Lucia Evans, Mohammed M. Ghannam, Nizar N. Mahomed, Sudha Singh, Patricia Morley-Forster, Mohammed Shamsah, Ian R. Thomson, Aaron D. Brown, Jeffrey I. Freedman, Robert J. Hudson, Murray Hong, Sean Hall, Brian Milne, Louie Wang, Chris Loomis, Ian Gilron, Debbie Tod, Allan Bell, Elizabeth Orr, Gary Dobson, Mustafa Karamanoglu, John V. Tyberg, Frances Chung, Charles Imarengiaye, Angela Rocchi, Lindy Forte, Elizabeth G. Van Den Kerkhof, David H. Goldstein, Mike Rimmer, Hoi Kwan Lee, Isabelle Charest, René Martin, François Plante, Shaheen Shaikh, Damian Yung, Mark Bernstein, Ngozi Imasogie, David Wong, Ken Luk, Suntheralingam Yogendran, Atul Prabhu, Ayman Hendy, Glenn McGuire, Jean Wong, M. Denise Daley, Peter H. Norman, Una Srejic, Thomas Dougherty, Sarah Hogervorst, Thomas M. Hemmerling, Joachim Schmidt, Pierre Beaulieu, Klaus E. Jacobi, Pamela H. Lennox, Kelly V. Mayson, Toshimi Arai, Kaori Saito, Masao Yamashita, Alain Gauthier, Daniel Boudreault, Dominique C. Girard, Louie T. S. Wang, Nancy Sikich, Guy Petroz, Jerrold Lerman, Gregory M. T. Hare, Andrew J. Baker, Kathryn M. Hum, Steve Y. Kim, Aiala Barr, C. David Mazer, Terrance A. Yemen, Thomas Howlett, Andrew Baker, Nicholas Phan, N. Persaud, Min Zhao, Elaine Liu, Michael Fehlings, Davinia E. Withington, T. AlAyed, G. Michael Davis, David M. Ansley, B. S. Dhaliwal, Zhengyuan Xia, Anthony M. -H. Ho, Anna Lee, Elizabeth Ling, Alan Daly, Kevin Teoh, Theodore E. Warkentin, David V. Godin, Thomas K. H. Chang, Joanne D. Fortier, Fadi Basile, Ignacio Prieto, David Mazer, Peter Duke, Barry Finegan, Davy Cheng, Richard Hall, B. Lim, J. Shannon, C. M. Ho, S. K. Tsai, Margaret Srebrnjak, Vivien Walsh, Geena Joseph, Teresa Valois Gomez, Carmen Rivero Fuenmayor, Paul S. Bach, Allaudin Kamani, Joanne Douglas, Mark Esler, Vit Gunka, Pamela Angle, Sam Tang, Dorothy Thompson, Jean Kronberg, Anwar Morgan, Craig H. Leicht, Ivan A. Velickovic, David T. Raphael, Maxim Benbassat, Dimiter Arnaudov, Alex Bohorquez, Bita Nasseri, D. John Doyle, Jacelyn Kolman, Ian Keith, Pamela J. Morgan, Doreen Cleave-Hogg, Susan Eveleigh, Jordan Tarshis, Sharon Davies, John Doyle, Heather Lee Loughlin, J. Patrick O’Connor, John F. Dolman, Fred S. Mikelberg, Gordana Dulovic, Brian G. Feagan, Cindy J. Wong, Alexandra Kirkley, D. W. C. Johnston, Frank C. Smith, Paul Whitsitt, William Li Pi Shanl, Steven B. Backman, Jeffrey Barkun, Peter Metrakos, John Tchervenkov, Mary Jane Salpeter, Leah Jamnicky, Michael Jewett, Ramiro Arellano, Brian Muirhead, Saifundin Rashiq, Meera Shah, Vikki Wilkinson, Samantha J. Woolsey, Barry A. Finegan, Carol Fiorilli, Joel L. Parlow, Nicole D. Avery, George N. Djaiani, Jayanta Muhkerji, Jacek M. Karski, Jo A. Carroll, Stuart McCluskey, Linda Harris, Jan Paton, Emmanuel Kanetos, William G. Williams, Cristina Hurtado, Manoj Gandhi, Sandy Clanachan, Woo Jong Shin, Bruce, D. Winegar, Jae Hang Shim, Woo Jae Jeon, Kyung Hun Kim, Bing Wang, David P. Archer, Naaznin Samanani, Sheldon H. Roth, Claudia Coimbra, Manon Choinière, Denis Babin, Francois Donati, Cynthia L. Henderson, John H. P. Friesen, Michael Jacka, Alan Cheng, Finlay McAlister, Jessie A. Leak, Tao Bui, Dy Nguyen, Alicia Kowalski, Keruyi Popat, Henry Kuerer, Paul Serowka, Kim Turner, Ted Ashbury, Tianlong Wang, Driss El-Kebir, Bernard Hubert, Ruud A. W. Veldhuizen, Dominique Gauvin, Gilbert Blaise, Fan Yang, Patricia Amicone

Publikováno v: Canadian Journal of Anaesthesia. 49:A60-A148

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2b6e5db8d663fbfb97fef7ed852c3d4d
https://doi.org/10.1007/bf03018138

TOK1 Is a Volatile Anesthetic Stimulated K+Channel

Autor: John Forsayeth, Spencer C. Yost, Dmitri Leonoudakis, Andrew T. Gray, Bruce D. Winegar

Publikováno v: Anesthesiology. 88:1076-1084

Background Volatile anesthetic agents can activate the S channel, a baseline potassium (K+) channel, of the marine mollusk Aplysia. To investigate whether cloned ion channels with electrophysiologic properties similar to the S channel (potassium sele

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9c42ed6dbd6468519d47b3ef69f653a
https://doi.org/10.1097/00000542-199804000-00029

Subconductance block of single mechanosensitive ion channels in skeletal muscle fibers by aminoglycoside antibiotics

Autor: C. M. Haws, Bruce D. Winegar, Jeffry B. Lansman

Publikováno v: The Journal of General Physiology
The Journal of general physiology, vol 107, iss 3

The activity of single mechanosensitive channels was recorded from cell-attached patches on acutely isolated skeletal muscle fibers from the mouse. The experiments were designed to investigate the mechanism of channel block produced by externally app

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a055eb176745be39cb66df93946236c
https://doi.org/10.1085/jgp.107.3.433

Localization of the tandem pore domain K+ channel KCNK5 (TASK-2) in the rat central nervous system

Autor: Anja Gabriel, Mona Abdallah, C.Spencer Yost, Bruce D Winegar, Christoph H Kindler

Publikováno v: Brain research. Molecular brain research. 98(1-2)

Tandem pore domain K+ channels (2P K+ channels) are responsible for background K+ currents. 2P K+ channels are the most numerous encoded K+ channels in the Caenorhabditis elegans and Drosophila melanogaster genomes and to date 14 human 2P K+ channels

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29d450165f25f150eb156d28911e3320
https://pubmed.ncbi.nlm.nih.gov/11834308