Zobrazeno 1 - 10
of 335
pro vyhledávání: '"Bruce D. Levy"'
Autor:
Jamie L. Everman, Satria P. Sajuthi, Maude A. Liegeois, Nathan D. Jackson, Erik H. Collet, Michael C. Peters, Maurizio Chioccioli, Camille M. Moore, Bhavika B. Patel, Nathan Dyjack, Roger Powell, Cydney Rios, Michael T. Montgomery, Celeste Eng, Jennifer R. Elhawary, Angel C. Y. Mak, Donglei Hu, Scott Huntsman, Sandra Salazar, Luigi Feriani, Ana Fairbanks-Mahnke, Gianna L. Zinnen, Cole R. Michel, Joe Gomez, Xing Zhang, Vivian Medina, Hong Wei Chu, Pietro Cicuta, Erin D. Gordon, Pamela Zeitlin, Victor E. Ortega, Nichole Reisdorph, Eleanor M. Dunican, Monica Tang, Brett M. Elicker, Travis S. Henry, Eugene R. Bleecker, Mario Castro, Serpil C. Erzurum, Elliot Israel, Bruce D. Levy, David T. Mauger, Deborah A. Meyers, Kaharu Sumino, David S. Gierada, Annette T. Hastie, Wendy C. Moore, Loren C. Denlinger, Nizar N. Jarjour, Mark L. Schiebler, Sally E. Wenzel, Prescott G. Woodruff, Jose Rodriguez-Santana, Chad G. Pearson, Esteban G. Burchard, John V. Fahy, Max A. Seibold
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract By incompletely understood mechanisms, type 2 (T2) inflammation present in the airways of severe asthmatics drives the formation of pathologic mucus which leads to airway mucus plugging. Here we investigate the molecular role and clinical si
Externí odkaz:
https://doaj.org/article/e5fbd453726447a6a3e42371a05beeb5
Autor:
Pier Giorgio Puzzovio, Hadas Pahima, Tresa George, David Mankuta, Ron Eliashar, Ekaterini Tiligada, Bruce D. Levy, Francesca Levi-Schaffer
Publikováno v:
Pharmacological Research, Vol 189, Iss , Pp 106691- (2023)
Background: Mast cells are initiators and main effectors of allergic inflammation, together with eosinophils, with whom they can interact in a physical and soluble cross-talk with marked pro-inflammatory features, the Allergic Effector Unit. The pro-
Externí odkaz:
https://doaj.org/article/8b8cdaaa773d47808e180f9133afa99f
Autor:
Victoria L. M. Herrera, Allan J. Walkey, Mai Q. Nguyen, Christopher M. Gromisch, Julie Z. Mosaddhegi, Matthew S. Gromisch, Bakr Jundi, Soeren Lukassen, Saskia Carstensen, Ridiane Denis, Anna C. Belkina, Rebecca M. Baron, Mayra Pinilla-Vera, Meike Mueller, W. Taylor Kimberly, Joshua N. Goldstein, Irina Lehmann, Angela R. Shih, Roland Eils, Bruce D. Levy, Nelson Ruiz-Opazo
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-24 (2022)
Abstract Neutrophil-mediated secondary tissue injury underlies acute respiratory distress syndrome (ARDS) and progression to multi-organ-failure (MOF) and death, processes linked to COVID-19-ARDS. This secondary tissue injury arises from dysregulated
Externí odkaz:
https://doaj.org/article/e3433c566fb14028b1c283831cb361bc
Autor:
Takuya Hino, Mizuki Nishino, Vladimir I. Valtchinov, Staci Gagne, Elizabeth Gay, Noriaki Wada, Shu Chi Tseng, Bruno Madore, Charles R.G. Guttmann, Kousei Ishigami, Yi Li, David C. Christiani, Gary M. Hunninghake, Bruce D. Levy, Kenneth M. Kaye, Hiroto Hatabu
Publikováno v:
European Journal of Radiology Open, Vol 10, Iss , Pp 100483- (2023)
Purpose: To investigate the association of the maximal severity of pneumonia on CT scans obtained within 6-week of diagnosis with the subsequent development of post-COVID-19 lung abnormalities (Co-LA). Methods: COVID-19 patients diagnosed at our hosp
Externí odkaz:
https://doaj.org/article/a6858ee7f73e4615ada59ca67fb5748c
Autor:
Thayse R. Brüggemann, Troy Carlo, Nandini Krishnamoorthy, Melody G. Duvall, Raja-Elie E. Abdulnour, Julie Nijmeh, Hong Yong Peh, Harilaos Filippakis, Roxanne H. Croze, Byoungsook Goh, Sungwhan F. Oh, Bruce D. Levy
Publikováno v:
iScience, Vol 25, Iss 10, Pp 105185- (2022)
Summary: Lipid phosphate phosphatases are a family of enzymes with diverse cellular metabolic functions. Phospholipid phosphatase 6 (PLPP6) is a regulator of cellular polyisoprenyl phosphates; however, its in vivo functions remain to be determined. H
Externí odkaz:
https://doaj.org/article/dba573f5d9f9430aac6578dbdef405d5
Autor:
Luciana P. Tavares, Thayse R. Brüggemann, Rafael M. Rezende, Marina G. Machado, R. Elaine Cagnina, Ashley E. Shay, Cristiana C. Garcia, Julie Nijmeh, Mauro M. Teixeira, Bruce D. Levy
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT Influenza A virus (IAV) infections are a leading cause of mortality worldwide. Excess mortality during IAV epidemics and pandemics is attributable to secondary bacterial infections, particularly pneumonia caused by Streptococcus pneumoniae.
Externí odkaz:
https://doaj.org/article/3a864d6cb7fe4807bf4973222976c38d
Autor:
Silva Kasela, Victor E. Ortega, Molly Martorella, Suresh Garudadri, Jenna Nguyen, Elizabeth Ampleford, Anu Pasanen, Srilaxmi Nerella, Kristina L. Buschur, Igor Z. Barjaktarevic, R. Graham Barr, Eugene R. Bleecker, Russell P. Bowler, Alejandro P. Comellas, Christopher B. Cooper, David J. Couper, Gerard J. Criner, Jeffrey L. Curtis, MeiLan K. Han, Nadia N. Hansel, Eric A. Hoffman, Robert J. Kaner, Jerry A. Krishnan, Fernando J. Martinez, Merry-Lynn N. McDonald, Deborah A. Meyers, Robert Paine, Stephen P. Peters, Mario Castro, Loren C. Denlinger, Serpil C. Erzurum, John V. Fahy, Elliot Israel, Nizar N. Jarjour, Bruce D. Levy, Xingnan Li, Wendy C. Moore, Sally E. Wenzel, Joe Zein, NHLBI SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS), NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Charles Langelier, Prescott G. Woodruff, Tuuli Lappalainen, Stephanie A. Christenson
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-17 (2021)
Abstract Background The large airway epithelial barrier provides one of the first lines of defense against respiratory viruses, including SARS-CoV-2 that causes COVID-19. Substantial inter-individual variability in individual disease courses is hypot
Externí odkaz:
https://doaj.org/article/87ab72a86e144f1c976576cc59d3efd7
Autor:
Noriaki Wada, Yi Li, Takuya Hino, Staci Gagne, Vladimir I. Valtchinov, Elizabeth Gay, Mizuki Nishino, Bruno Madore, Charles R.G. Guttmann, Sheila Bond, Kousei Ishigami, Gary M. Hunninghake, Bruce D. Levy, Kenneth M. Kaye, David C. Christiani, Hiroto Hatabu
Publikováno v:
European Journal of Radiology Open, Vol 9, Iss , Pp 100456- (2022)
Purpose: To investigate the effect of vaccinations and boosters on the severity of COVID-19 pneumonia on CT scans during the period of Delta and Omicron variants. Methods: Retrospectively studied were 303 patients diagnosed with COVID-19 between July
Externí odkaz:
https://doaj.org/article/128f216640b14d07a32320b2e44ebec9
Autor:
Bakr Jundi, Do-Hyun Lee, Hyungkook Jeon, Melody G. Duvall, Julie Nijmeh, Raja-Elie E. Abdulnour, Mayra Pinilla-Vera, Rebecca M. Baron, Jongyoon Han, Joel Voldman, Bruce D. Levy
Publikováno v:
JCI Insight, Vol 6, Iss 15 (2021)
Sepsis is a critical illness characterized by dysregulated inflammatory responses lacking counter-regulation. Specialized proresolving mediators are agonists for antiinflammation and for promoting resolution, and they are protective in preclinical se
Externí odkaz:
https://doaj.org/article/b595397ae9854810a9f346a8ea230f92
Autor:
Katherine H. Walker, Nandini Krishnamoorthy, Thayse R. Brüggemann, Ashley E. Shay, Charles N. Serhan, Bruce D. Levy
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Viral pneumonias are a major cause of morbidity and mortality, owing in part to dysregulated excessive lung inflammation, and therapies to modulate host responses to viral lung injury are urgently needed. Protectin conjugates in tissue regeneration 1
Externí odkaz:
https://doaj.org/article/9375ae0da5bd41c392dc0477946984d8