PC12 Variants Deficient in Catecholamine Transport

Autor: Mao‐bin Zhang, Catherine M. Bitler, Bruce D. Howard

Publikováno v: Journal of Neurochemistry. 47:1286-1293

We have isolated PC12 cell variants deficient in transporter-mediated uptake of 3,4-dihydroxyphenylethylamine (dopamine). The variants either were obtained nonselectively, or they were selected by resistance to guanethidine or N-methyl-4-phenyl-1,2,3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17b2c544bc673e95f85e07e163b324a0
https://doi.org/10.1111/j.1471-4159.1986.tb00752.x

Wnt-1 inhibits nerve growth factor-induced differentiation of PC12 cells by preventing the induction of some but not all late-response genes

Autor: Tomoko Itsukaichi, Alice H Chou, Shuang Zheng, Bruce D. Howard

Publikováno v: Molecular Brain Research. 77:232-245

The vertebrate Wnt-1 proto-oncogene is expressed transiently in embryonic brain and functions in the development of the central nervous system and neural crest. The role of Wnt-1 in neural crest development appears to be to increase the number of cer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e52c92e590cb6239118eb3d638eeb44
https://doi.org/10.1016/s0169-328x(00)00058-9

K252a-potentiation of EGF-induced neurite outgrowth from PC12 cells is not mimicked or blocked by other protein kinase activators or inhibitors

Autor: Can-fang Wu, Bruce D. Howard

Publikováno v: Developmental Brain Research. 86:217-226

Epidermal growth factor (EGF) has recently been shown to cause certain strains of PC12 cells to extend short neurites. This EGF-induced differentiation of PC12 was found to be potentiated by the protein kinase inhibitor, K252a, in that PC12 cells tre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::703c584b95b9932d1914439504a3f39c
https://doi.org/10.1016/0165-3806(95)00028-c

K252a potentiates epidermal growth factor-induced differentiation of PC12 cells

Autor: C.-F. Wu, Bruce D. Howard, Mao‐bin Zhang

Publikováno v: Journal of Neuroscience Research. 36:539-550

Epidermal growth factor (EFG) induced short neurites in two different strains of PC12 cells. The length of the EGF-induced neurites was markedly increased in the presence of the protein kinase inhibitor K252a, which is known to inhibit differentiatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e41fa8070a6dfc343d13bdc4b6b447e
https://doi.org/10.1002/jnr.490360506

Episodic ataxia associated with EAAT1 mutation C186S affecting glutamate reuptake

Autor: Bruce D. Howard, Elles M. J. Boon, Hafsa Mamsa, Stef L. M. Bakker, Rune R. Frants, Anine H. Stam, Michel D. Ferrari, Arn M. J. M. van den Maagdenberg, Boukje de Vries, Robert W. Baloh, Gisela M. Terwindt, Kaate R J Vanmolkot, Joost Haan, Joanna C. Jen, Jijun Wan

Publikováno v: Archives of Neurology, 66(1), 97-101. American Medical Association
De Vries, B, Mamsa, H, Stam, A H, Wan, J, Bakker, S L M, Vanmolkot, K R J, Haan, J, Terwindt, G M, Boon, E M J, Howard, B D, Frants, R R, Baloh, R W, Ferrari, M D, Jen, J C & Van Den Maagdenberg, A M J M 2009, ' Episodic ataxia associated with EAAT1 mutation C186S affecting glutamate reuptake ', Archives of Neurology, vol. 66, no. 1, pp. 97-101 . https://doi.org/10.1001/archneurol.2008.535

Background Episodic ataxia (EA) is variably associated with additional neurologic symptoms. At least 4 genes have been implicated. Recently, a mutation in the SLC1A3 gene encoding the glutamate transporter EAAT1 was identified in a patient with sever

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6777acfe54999158d4dc26418bfdb536
https://research.vumc.nl/en/publications/b8b3148f-d9df-4e6c-b313-97f1a6175f99