Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Bruce D. Harris"'
Autor:
Birdella D. Kenney, Cynthia A. Maryanoff, John E. Mills, Bruce D. Harris, Rosie Chang, Roland Glaser, Frank J. Villani, Armin Roessler, Michael Breslav, Brigitte E. Segmuller
Publikováno v:
The Journal of Organic Chemistry. 72:9798-9801
An efficient process to produce kilogram quantities of a key argininylbenzo[d]thiazole intermediate was developed for the preparation of the tryptase inhibitor RWJ-56423. A variety of activated arginine esters and benzo[d]thiazole nucleophiles were e
Autor:
John T. Hortenstine, Frank J. Villani, Lorraine Scott, Bruce D. Harris, Robin R. H. Webster, John E. Mills, Armin Roessler, Christian Weh, Kirk L. Sorgi, Cynthia A. Maryanoff, Cesco-Cancian Sergio, Michael Justus, Judith H. Cohen, Mary Ellen Bos, Stefan Muller
Publikováno v:
Organic Process Research & Development. 7:866-872
Elarofiban is a novel, nonpeptide, orally active fibrinogen receptor antagonist useful for the treatment of platelet mediated thrombotic disorders (Costanzo, M. J.; Hoekstra, W. J.; Maryanoff, B. E. WO, 97/41102, 1997). Herein we describe the process
Autor:
Bruce E. Maryanoff, Han-Cheng Zhang, Cynthia A. Maryanoff, Bruce D. Harris, Michael J. Costanzo, Edward C. Lawson
Publikováno v:
The Journal of Organic Chemistry. 63:7964-7981
For conformationally unconstrained, acyclic organic compounds, the control of stereogenic centers at remote positions of a chain, that is, at a distance of four or more atom centers, remains a challenging problem in asymmetric synthesis. We report on
Autor:
Bruce D. Harris, Frank J. Villani, Jack A. Kauffman, Hoekstra William J, Patricia Andrade-Gordon, Michael J. Costanzo, Judith H. Cohen, Bruce P. Damiano, Stephen C. Yabut, David F. McComsey, Bruce E. Maryanoff, Barbara J. Haertlein, Patricia Keane
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:2371-2376
A study of β-turn peptide mimetics, related to the C-terminal γ-chain of fibrinogen and containing a nipecotic acid scaffold, led to RWJ-50042 (1), an interesting fibrinogen receptor (GPIIb/IIIa) antagonist. To enhance potency, we employed solid-ph
Publikováno v:
Tetrahedron Letters. 37:7897-7900
Reduction of acyclic e-hydroxy ketone 3 with R-Alpine-Hydride® in methylene chloride provided a strong preponderance of the anti diastereomer of 4 (anti:syn = 12:1). This impressive 1,6 stereoselectivity is attributed to bicyclic chelation control o
Autor:
and Cynthia A. Maryanoff, Bruce D. Harris, Ahmed F. Abdel-Magid, Rekha D. Shah, Kenneth G. Carson
Publikováno v:
The Journal of Organic Chemistry. 61:3849-3862
Sodium triacetoxyborohydride is presented as a general reducing agent for the reductive amination of aldehydes and ketones. Procedures for using this mild and selective reagent have been developed for a wide variety of substrates. The scope of the re
Publikováno v:
ChemInform. 22
Didemnins A, B, and C were efficiently prepared in a stereocontrolled manner, producing the common macrocycle and, in a separate step, introducing the substituents on the amino group of L-threonine as optically pure units. We envisaged that disconnec
Publikováno v:
ChemInform. 25
Publikováno v:
ChemInform. 28
Reduction of acyclic e-hydroxy ketone 3 with R-Alpine-Hydride® in methylene chloride provided a strong preponderance of the anti diastereomer of 4 (anti:syn = 12:1). This impressive 1,6 stereoselectivity is attributed to bicyclic chelation control o
Publikováno v:
ChemInform. 27