Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Bruce D Wyse"'
Autor:
Pegah Varamini, Friederike M Mansfeld, Joanne T Blanchfield, Bruce D Wyse, Maree T Smith, Istvan Toth
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e41909 (2012)
To enhance the drug-like properties of the endogenous opioid peptide endomorphin-1 (1 = Tyr-Pro-Trp-Phe-NH(2)), the N-terminus of the peptide was modified with 2-aminodecanoic acid, resulting in compound 3. Tyr in compound 1 was replaced with 2,6-dim
Externí odkaz:
https://doaj.org/article/21fea07637ff47759063f511330e0f1d
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 46:676-685
Painful diabetic neuropathy (PDN) is a type of peripheral neuropathic pain that develops as a consequence of prolonged hyperglycaemia-induced injury to the long nerves. Apart from pain, PDN is also characterized by morphine hyposensitivity. Intriguin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c95a4b5abe2432a429535736161fc20f
https://doi.org/10.1111/1440-1681.13091
https://doi.org/10.1111/1440-1681.13091
Autor:
Åsa Andersson, Maree T. Smith, Ai Leen Lam, Julia Magiera, Nursyazwani Rethwan, Andy Kuo, Wim Meutermans, Richard J. Lewis, Bruce D. Wyse
Publikováno v:
European Journal of Pharmacology. 872:172947
Previously, we showed that no two of seven opioids administered by the intracerebroventricular route had the same potency rank order for evoking antinociception, constipation and respiratory depression in rats. To gain insight at the cellular level,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f00fc358c463ce7fc4725fa2aabe0240
https://doi.org/10.1016/j.ejphar.2020.172947
https://doi.org/10.1016/j.ejphar.2020.172947
Publikováno v:
Behavioural Pharmacology. 25:732-740
Chemotherapy-induced peripheral neuropathy (CIPN) is the major dose-limiting side-effect of many front-line anticancer drugs. This study was designed to establish and pharmacologically characterize a refined rat model of cisplatin-induced CIPN. Adult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffb077db1225177619a85f93b41da46f
https://doi.org/10.1097/fbp.0000000000000090
https://doi.org/10.1097/fbp.0000000000000090
Publikováno v:
British Journal of Pharmacology. 172:532-548
Background and Purpose For patients experiencing inadequate analgesia and intolerable opioid-related side effects on one strong opioid analgesic, pain relief with acceptable tolerability is often achieved by rotation to a second strong opioid. These
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fae515d2c97a28f4083e92f4305c2b3c
https://doi.org/10.1111/bph.12696
https://doi.org/10.1111/bph.12696
Publikováno v:
Behavioural Pharmacology. 25:137-146
Individuals infected with the HIV and taking certain antiretroviral drugs to suppress viral replication have a high prevalence of neuropathic pain that is not alleviated by analgesic/adjuvant drugs that are often efficacious for the relief of other t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b3fafa802c82faf9e7c2d3d9077b3bf
https://doi.org/10.1097/fbp.0000000000000025
https://doi.org/10.1097/fbp.0000000000000025
Autor:
Ai-Leen Lam, Bowen Song, Sunder Sekar, Cai Jun, Akihiro Ambo, Ma Yu, Lawrence H. Lazarus, Maree T. Smith, Julia Magiera, Bruce D. Wyse, Tingyou Li, Yunxin Cai, Yusuke Sasaki
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:2208-2219
Analogues of endomorphin (Dmt-Pro-Xaa-Xaa-NH2) modified at position 4 or at positions 4 and 3, and tripeptides (Dmt-Pro-Xaa-NH2) modified at position 3, with various phenylalanine analogues (Xaa=Trp, 1-Nal, 2-Nal, Tmp, Dmp, Dmt) were synthesized and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::303b5849d4a8b5e37b2459c41ef22f58
https://doi.org/10.1016/j.bmc.2014.02.015
https://doi.org/10.1016/j.bmc.2014.02.015
Publikováno v:
Pain Medicine. 14:1557-1568
ObjectiveThere is an unmet clinical need for novel analgesics for neuropathic pain. This study was designed to elucidate the mechanism through which EMA300, a small molecule antagonist of the angiotensin II type 2 receptor (AT(2)R) with >1,000-fold s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9612cf4ce6743a01011a2ccfb08adf5
https://doi.org/10.1111/pme.12157
https://doi.org/10.1111/pme.12157
Publikováno v:
Pharmacology Biochemistry and Behavior. 106:33-46
The major limitation of currently utilized rodent models of prostate cancer (PCa)-induced bone pain (PCIBP) involving intra-osseous injection of PCa cells, is their relatively short-term applicability due to progressive deterioration of animal health
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5da152c1552d1aa831ffe2f8e2ee3310
https://doi.org/10.1016/j.pbb.2013.02.020
https://doi.org/10.1016/j.pbb.2013.02.020
Publikováno v:
Pain Medicine. 14:692-705
Objective Neuropathic pain is an area of unmet clinical need. The objective of this study was to define the pharmacokinetics, oral bioavailability, and efficacy in rats of small molecule antagonists of the angiotensin II type 2 receptor (AT2R) for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d6d9e683208916f21a6c858929a60cd
https://doi.org/10.1111/pme.12063
https://doi.org/10.1111/pme.12063