Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Bruce D Wines"'
Autor:
Ebene R Haycroft, Timon Damelang, Ester Lopez, Mark A Rodgers, Bruce D Wines, Mark Hogarth, Cassaundra L Ameel, Stephen J Kent, Charles A Scanga, Shelby L O'Connor, Amy W Chung
Publikováno v:
Clinical & Translational Immunology, Vol 12, Iss 11, Pp n/a-n/a (2023)
Abstract Objectives Tuberculosis (TB) remains a substantial cause of morbidity and mortality among people living with human immunodeficiency virus (HIV) worldwide. However, the immunological mechanisms associated with the enhanced susceptibility amon
Externí odkaz:
https://doaj.org/article/4a87f15db7084ad890bf9bc3adf4e697
Autor:
Brendon Y Chua, Toshiki Sekiya, Marios Koutsakos, Naoki Nomura, Louise C Rowntree, Thi H O Nguyen, Hayley A McQuilten, Marumi Ohno, Yuki Ohara, Tomohiro Nishimura, Masafumi Endo, Yasushi Itoh, Jennifer R Habel, Kevin J Selva, Adam K Wheatley, Bruce D Wines, P Mark Hogarth, Stephen J Kent, Amy W Chung, David C Jackson, Lorena E Brown, Masashi Shingai, Katherine Kedzierska, Hiroshi Kida
Publikováno v:
PLoS Pathogens, Vol 18, Iss 10, p e1010891 (2022)
Although antibody-inducing split virus vaccines (SV) are currently the most effective way to combat seasonal influenza, their efficacy can be modest, especially in immunologically-naïve individuals. We investigated immune responses towards inactivat
Externí odkaz:
https://doaj.org/article/2b58f7e83fd641de88b948e2249be55b
Autor:
Elizabeth H Aitken, Timon Damelang, Amaya Ortega-Pajares, Agersew Alemu, Wina Hasang, Saber Dini, Holger W Unger, Maria Ome-Kaius, Morten A Nielsen, Ali Salanti, Joe Smith, Stephen Kent, P Mark Hogarth, Bruce D Wines, Julie A Simpson, Amy W Chung, Stephen J Rogerson
Publikováno v:
eLife, Vol 10 (2021)
Background: Plasmodium falciparum causes placental malaria, which results in adverse outcomes for mother and child. P. falciparum-infected erythrocytes that express the parasite protein VAR2CSA on their surface can bind to placental chondroitin sulfa
Externí odkaz:
https://doaj.org/article/80eddfad4d8d43b9ba30c10fe53a5992
Systems serology detects functionally distinct coronavirus antibody features in children and elderly
Autor:
Kevin J. Selva, Carolien E. van de Sandt, Melissa M. Lemke, Christina Y. Lee, Suzanne K. Shoffner, Brendon Y. Chua, Samantha K. Davis, Thi H. O. Nguyen, Louise C. Rowntree, Luca Hensen, Marios Koutsakos, Chinn Yi Wong, Francesca Mordant, David C. Jackson, Katie L. Flanagan, Jane Crowe, Shidan Tosif, Melanie R. Neeland, Philip Sutton, Paul V. Licciardi, Nigel W. Crawford, Allen C. Cheng, Denise L. Doolan, Fatima Amanat, Florian Krammer, Keith Chappell, Naphak Modhiran, Daniel Watterson, Paul Young, Wen Shi Lee, Bruce D. Wines, P. Mark Hogarth, Robyn Esterbauer, Hannah G. Kelly, Hyon-Xhi Tan, Jennifer A. Juno, Adam K. Wheatley, Stephen J. Kent, Kelly B. Arnold, Katherine Kedzierska, Amy W. Chung
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Antibody responses to SARS-CoV-2 are critical in the immune response to infection, but the potential cross-reactivity to other human corona viruses is poorly appreciated. Here the authors apply a systems based approach to characterise the antibody re
Externí odkaz:
https://doaj.org/article/b3735969bc2442d3bede1a835ba02866
Autor:
Gaoqian Feng, Bruce D. Wines, Liriye Kurtovic, Jo-Anne Chan, Philippe Boeuf, Vanessa Mollard, Anton Cozijnsen, Damien R. Drew, Rob J. Center, Daniel L. Marshall, Sandra Chishimba, Geoffrey I. McFadden, Arlene E. Dent, Kiprotich Chelimo, Michelle J. Boyle, James W. Kazura, P. Mark Hogarth, James G. Beeson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Antibodies plays critical roles in the adaptive immune response to infectious agents including malaria. Here the authors defined antibody interactions with -Fcγ-receptors expressed on immune cells with sporozoites of Plasmodium falciparum, and ident
Externí odkaz:
https://doaj.org/article/6df085e64a2441099441e81ae6947fa5
Autor:
Melissa M. Lemke, Robert M. Theisen, Emily R. Bozich, Milla R. McLean, Christina Y. Lee, Ester Lopez, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sorachai Nitayaphan, Sven Kratochvil, Bruce D. Wines, P. Mark Hogarth, Stephen J. Kent, Amy W. Chung, Kelly B. Arnold
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Fc-mediated immune functions have been correlated with protection in the RV144 HIV vaccine trial and are important for immunity to a range of pathogens. IgG antibodies (Abs) that form complexes with Fc receptors (FcRs) on innate immune cells can acti
Externí odkaz:
https://doaj.org/article/35b3306aabcb40c09ff91806b53e7bb8
Autor:
Damian. A. Oyong, Jessica. R. Loughland, Megan. S.F. Soon, Jo-Anne Chan, Dean Andrew, Bruce D. Wines, P. Mark Hogarth, Stuart D. Olver, Alika D. Collinge, Antiopi Varelias, James G. Beeson, Enny Kenangalem, Ric N. Price, Nicholas M. Anstey, Gabriela Minigo, Michelle J. Boyle
Publikováno v:
EBioMedicine, Vol 75, Iss , Pp 103784- (2022)
Summary: Background: Protective malarial antibodies are acquired more rapidly in adults than children, independently of cumulative exposure, however the cellular responses mediating these differences are unknown. CD4 T-follicular helper (Tfh) cells h
Externí odkaz:
https://doaj.org/article/5dad9189a89a42f9808a70848568eb43
Autor:
Thomas S. Fulford, Huy Van, Nicholas A. Gherardin, Shuning Zheng, Marcin Ciula, Heidi E. Drummer, Samuel Redmond, Hyon-Xhi Tan, Irene Boo, Rob J. Center, Fan Li, Samantha L. Grimley, Bruce D. Wines, Thi H.O. Nguyen, Francesca L. Mordant, Paula Ellenberg, Louise C. Rowntree, Lukasz Kedzierski, Allen C. Cheng, Denise L. Doolan, Gail Matthews, Katherine Bond, P. Mark Hogarth, Zoe McQuilten, Kanta Subbarao, Katherine Kedzierska, Jennifer A. Juno, Adam K. Wheatley, Stephen J. Kent, Deborah A. Williamson, Damian F.J. Purcell, David A. Anderson, Dale I. Godfrey
Publikováno v:
EBioMedicine, Vol 74, Iss , Pp 103729- (2021)
Background: As vaccines against SARS-CoV-2 are now being rolled out, a better understanding of immunity to the virus, whether from infection, or passive or active immunisation, and the durability of this protection is required. This will benefit from
Externí odkaz:
https://doaj.org/article/b797a15ea4c145e7a13177048c7b5ebe
Autor:
Karunasinee Suphaphiphat, Sibylle Bernard-Stoecklin, Céline Gommet, Benoit Delache, Nathalie Dereuddre-Bosquet, Stephen J. Kent, Bruce D. Wines, P. Mark Hogarth, Roger Le Grand, Mariangela Cavarelli
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
HIV-1 infection is transmitted primarily by sexual exposure, with semen being the principal contaminated fluid. However, HIV-specific immune response in semen has been understudied. We investigated specific parameters of the innate, cellular, and hum
Externí odkaz:
https://doaj.org/article/34d77fb2988340c0860ef0bfa37e54ae
Autor:
Ester Lopez, Nichollas E. Scott, Bruce D. Wines, P. Mark Hogarth, Adam K. Wheatley, Stephen J. Kent, Amy W. Chung
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Evaluating the biophysical and functional nature of IgG is key to defining correlates of protection in infectious disease, and autoimmunity research cohorts, as well as vaccine efficacy trials. These studies often require small quantities of IgG to b
Externí odkaz:
https://doaj.org/article/ae86f405791b48d6aea05f5df18209eb