Zobrazeno 1 - 10
of 847
pro vyhledávání: '"Bruce D Walker"'
Autor:
Noah J Silverstein, Yetao Wang, Zachary Manickas-Hill, Claudia Carbone, Ann Dauphin, Brittany P Boribong, Maggie Loiselle, Jameson Davis, Maureen M Leonard, Leticia Kuri-Cervantes, MGH COVID-19 Collection & Processing Team, Nuala J Meyer, Michael R Betts, Jonathan Z Li, Bruce D Walker, Xu G Yu, Lael M Yonker, Jeremy Luban
Publikováno v:
eLife, Vol 11 (2022)
Background: Risk of severe COVID-19 increases with age, is greater in males, and is associated with lymphopenia, but not with higher burden of SARS-CoV-2. It is unknown whether effects of age and sex on abundance of specific lymphoid subsets explain
Externí odkaz:
https://doaj.org/article/800cf5781b104e70b2080fb87ce76c0d
Autor:
Vinicius A Vieira, Emily Adland, David F G Malone, Maureen P Martin, Andreas Groll, M Azim Ansari, Maria C Garcia-Guerrero, Mari C Puertas, Maximilian Muenchhoff, Claudia Fortuny Guash, Christian Brander, Javier Martinez-Picado, Alasdair Bamford, Gareth Tudor-Williams, Thumbi Ndung'u, Bruce D Walker, Veron Ramsuran, John Frater, Pieter Jooste, Dimitra Peppa, Mary Carrington, Philip J R Goulder
Publikováno v:
PLoS Pathogens, Vol 17, Iss 11, p e1010090 (2021)
Natural Killer (NK) cells contribute to HIV control in adults, but HLA-B-mediated T-cell activity has a more substantial impact on disease outcome. However, the HLA-B molecules influencing immune control in adults have less impact on paediatric infec
Externí odkaz:
https://doaj.org/article/2772898860cf475e98f5416e7e2940e4
Autor:
Elena Gonzalo-Gil, Patrick B Rapuano, Uchenna Ikediobi, Rebecca Leibowitz, Sameet Mehta, Ayse K Coskun, J Zachary Porterfield, Teagan D Lampkin, Vincent C Marconi, David Rimland, Bruce D Walker, Steven Deeks, Richard E Sutton
Publikováno v:
eLife, Vol 8 (2019)
HIV +Elite and Viremic controllers (EC/VCs) are able to control virus infection, perhaps because of host genetic determinants. We identified 16% (21 of 131) EC/VCs with CD4 +T cells with resistance specific to R5-tropic HIV, reversed after introducti
Externí odkaz:
https://doaj.org/article/fc6ea9035e324f85a1801ebed0225c9a
Autor:
Allison S Thomas, Kimberley L Jones, Rajesh T Gandhi, Deborah K McMahon, Joshua C Cyktor, Dora Chan, Szu-Han Huang, Ronald Truong, Alberto Bosque, Amanda B Macedo, Colin Kovacs, Erika Benko, Joseph J Eron, Ronald J Bosch, Christina M Lalama, Samuel Simmens, Bruce D Walker, John W Mellors, R Brad Jones
Publikováno v:
PLoS Pathogens, Vol 13, Iss 9, p e1006629 (2017)
HIV-specific CD8+ T-cell responses limit viral replication in untreated infection. After the initiation of antiretroviral therapy (ART), these responses decay and the infected cell population that remains is commonly considered to be invisible to T-c
Externí odkaz:
https://doaj.org/article/296cd3ee852f419ca1a0fd1c12dbd3c1
Autor:
Ellen M Leitman, Christine D Palmer, Søren Buus, Fabian Chen, Lynn Riddell, Stuart Sims, Paul Klenerman, Asier Sáez-Cirión, Bruce D Walker, Paul R Hess, Marcus Altfeld, Philippa C Matthews, Philip J R Goulder
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0184496 (2017)
Antigen-specific T-cells are highly variable, spanning potent antiviral efficacy and damaging auto-reactivity. In virus infections, identifying the most efficacious responses is critical to vaccine design. However, current methods depend on indirect
Externí odkaz:
https://doaj.org/article/fb7a3d6217b74a1fa025d6dc51b45b58
Autor:
Boris Julg, Kathryn E. Stephenson, Frank Tomaka, Stephen R. Walsh, C. Sabrina Tan, Ludo Lavreys, Michal Sarnecki, Jessica L. Ansel, Diane G. Kanjilal, Kate Jaegle, Tessa Speidel, Joseph P. Nkolola, Erica N. Borducchi, Esmee Braams, Laura Pattacini, Eleanor Burgess, Shlomi Ilan, Yannic Bartsch, Katherine E. Yanosick, Michael S. Seaman, Daniel J. Stieh, Janine van Duijn, Wouter Willems, Merlin L. Robb, Nelson L. Michael, Bruce D. Walker, Maria Grazia Pau, Hanneke Schuitemaker, Dan H. Barouch
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-10 (2024)
Abstract Mosaic HIV-1 vaccines have been shown to elicit robust humoral and cellular immune responses in people living with HIV-1 (PLWH), that had started antiretroviral therapy (ART) during acute infection. We evaluated the safety and immunogenicity
Externí odkaz:
https://doaj.org/article/59601776515445b699048f239a5f3f75
Autor:
Alison E Mahan, Madeleine F Jennewein, Todd Suscovich, Kendall Dionne, Jacquelynne Tedesco, Amy W Chung, Hendrik Streeck, Maria Pau, Hanneke Schuitemaker, Don Francis, Patricia Fast, Dagna Laufer, Bruce D Walker, Lindsey Baden, Dan H Barouch, Galit Alter
Publikováno v:
PLoS Pathogens, Vol 12, Iss 6, p e1005694 (2016)
[This corrects the article DOI: 10.1371/journal.ppat.1005456.].
Externí odkaz:
https://doaj.org/article/38a0e1329c4b48319726437ed40f4767
Autor:
Damien C Tully, Colin B Ogilvie, Rebecca E Batorsky, David J Bean, Karen A Power, Musie Ghebremichael, Hunter E Bedard, Adrianne D Gladden, Aaron M Seese, Molly A Amero, Kimberly Lane, Graham McGrath, Suzane B Bazner, Jake Tinsley, Niall J Lennon, Matthew R Henn, Zabrina L Brumme, Philip J Norris, Eric S Rosenberg, Kenneth H Mayer, Heiko Jessen, Sergei L Kosakovsky Pond, Bruce D Walker, Marcus Altfeld, Jonathan M Carlson, Todd M Allen
Publikováno v:
PLoS Pathogens, Vol 12, Iss 5, p e1005619 (2016)
Due to the stringent population bottleneck that occurs during sexual HIV-1 transmission, systemic infection is typically established by a limited number of founder viruses. Elucidation of the precise forces influencing the selection of founder viruse
Externí odkaz:
https://doaj.org/article/247cdda96dd244d4b3f4719243dd631e
Autor:
R Brad Jones, Stefanie Mueller, Rachel O'Connor, Katherine Rimpel, Derek D Sloan, Dan Karel, Hing C Wong, Emily K Jeng, Allison S Thomas, James B Whitney, So-Yon Lim, Colin Kovacs, Erika Benko, Sara Karandish, Szu-Han Huang, Maria J Buzon, Mathias Lichterfeld, Alivelu Irrinki, Jeffrey P Murry, Angela Tsai, Helen Yu, Romas Geleziunas, Alicja Trocha, Mario A Ostrowski, Darrell J Irvine, Bruce D Walker
Publikováno v:
PLoS Pathogens, Vol 12, Iss 4, p e1005545 (2016)
Resting CD4+ T-cells harboring inducible HIV proviruses are a critical reservoir in antiretroviral therapy (ART)-treated subjects. These cells express little to no viral protein, and thus neither die by viral cytopathic effects, nor are efficiently c
Externí odkaz:
https://doaj.org/article/8d9eef0385234f16ae9fba721f3491fb
Autor:
Alison E Mahan, Madeleine F Jennewein, Todd Suscovich, Kendall Dionne, Jacquelynne Tedesco, Amy W Chung, Hendrik Streeck, Maria Pau, Hanneke Schuitemaker, Don Francis, Patricia Fast, Dagna Laufer, Bruce D Walker, Lindsey Baden, Dan H Barouch, Galit Alter
Publikováno v:
PLoS Pathogens, Vol 12, Iss 3, p e1005456 (2016)
Antibody effector functions, such as antibody-dependent cellular cytotoxicity, complement deposition, and antibody-dependent phagocytosis, play a critical role in immunity against multiple pathogens, particularly in the absence of neutralizing activi
Externí odkaz:
https://doaj.org/article/f6be0b9a5a874f1cbc6558a62cdcd27c