Zobrazeno 1 - 10
of 300
pro vyhledávání: '"Bruce D Trapp"'
Autor:
Zhihong Chen, Weiwei Hu, Mynor J. Mendez, Zachary C. Gossman, Anthony Chomyk, Brendan T. Boylan, Grahame J. Kidd, Timothy W. Phares, Cornelia C. Bergmann, Bruce D. Trapp
Publikováno v:
ASN Neuro, Vol 15 (2023)
The central nervous system (CNS) can be preconditioned to resist damage by peripheral pretreatment with low-dose gram-negative bacterial endotoxin lipopolysaccharide (LPS). Underlying mechanisms associated with transient protection of the cerebral co
Externí odkaz:
https://doaj.org/article/b4dc86464cac4cc9a5e6880b2e23680d
Autor:
Yasuyuki Kihara, Yunjiao Zhu, Deepa Jonnalagadda, William Romanow, Carter Palmer, Benjamin Siddoway, Richard Rivera, Ranjan Dutta, Bruce D. Trapp, Jerold Chun
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Multiple sclerosis (MS) is an immune-mediated demyelinating disease that alters central nervous system (CNS) functions. Relapsing-remitting MS (RRMS) is the most common form, which can transform into secondary-progressive MS (SPMS) that is associated
Externí odkaz:
https://doaj.org/article/253d48ea8e324c959cd159fe3faa35e5
Autor:
Selva Baltan, Safdar S. Jawaid, Anthony M. Chomyk, Grahame J. Kidd, Jacqueline Chen, Harsha D. Battapady, Ricky Chan, Ranjan Dutta, Bruce D. Trapp
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-15 (2021)
Abstract Cognitive dysfunction occurs in greater than 50% of individuals with multiple sclerosis (MS). Hippocampal demyelination is a prominent feature of postmortem MS brains and hippocampal atrophy correlates with cognitive decline in MS patients.
Externí odkaz:
https://doaj.org/article/b680dd10db08431a81269324a9403942
Autor:
Yushan Wan, Bo Feng, Yi You, Jie Yu, Cenglin Xu, Haibin Dai, Bruce D. Trapp, Peng Shi, Zhong Chen, Weiwei Hu
Publikováno v:
Cell Reports, Vol 33, Iss 5, Pp 108346- (2020)
Summary: Complex febrile seizures (FSs) lead to a high risk of intractable temporal lobe epilepsy during adulthood, yet the pathological process of complex FSs is largely unknown. Here, we demonstrate that activated microglia extensively associated w
Externí odkaz:
https://doaj.org/article/feb994f2aa354d63966054fa6906f2f8
Autor:
Aniruddha Das, Chinthasagar Bastian, Lexie Trestan, Jason Suh, Tanujit Dey, Bruce D. Trapp, Selva Baltan, Hod Dana
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2020)
Demyelination of axons in the central nervous system (CNS) is a hallmark of multiple sclerosis (MS) and other demyelinating diseases. Cycles of demyelination, followed by remyelination, appear in the majority of MS patients and are associated with th
Externí odkaz:
https://doaj.org/article/a82e56dd1b304380918d61d9edbfb218
Autor:
Anthony M. Chomyk, Christina Volsko, Ajai Tripathi, Sadie A. Deckard, Bruce D. Trapp, Robert J. Fox, Ranjan Dutta
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Multiple Sclerosis (MS) is an immune-mediated demyelinating disease of the human central nervous system (CNS). Memory impairments and hippocampal demyelination are common features in MS patients. Our previous data have shown that demyelinati
Externí odkaz:
https://doaj.org/article/0f24d60627be461e9f277645c33faa5b
Autor:
Ajai Tripathi, Christina Volsko, Jessie P. Garcia, Eneritz Agirre, Kevin C. Allan, Paul J. Tesar, Bruce D. Trapp, Goncalo Castelo-Branco, Fraser J. Sim, Ranjan Dutta
Publikováno v:
Cell Reports, Vol 29, Iss 4, Pp 904-919.e9 (2019)
Summary: Remyelination requires the generation of new oligodendrocytes (OLs), which are derived from oligodendrocyte progenitor cells (OPCs). Maturation of OPCs into OLs is a multi-step process. Here, we describe a microRNA expressed by OLs, miR-27a,
Externí odkaz:
https://doaj.org/article/97335eff7e1749298f244aa49f96c578
Publikováno v:
Myelin ISBN: 9780203746141
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52c7a9cb5e9107921fbdc422924f225e
https://doi.org/10.1201/9780203746141-16
https://doi.org/10.1201/9780203746141-16
Autor:
Laura Ghezzi, Bryan Bollman, Luca De Feo, Laura Piccio, Bruce D. Trapp, Robert E. Schmidt, Anne H. Cross
Publikováno v:
Laboratory Investigation. 103:100128
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4471c25fa333b43d17019dba8d4db088
https://doi.org/10.1016/j.labinv.2023.100128
https://doi.org/10.1016/j.labinv.2023.100128
Publikováno v:
Curr Opin Neurol
Purpose of review In multiple sclerosis, currently approved disease-modifying treatments are effective in modulating peripheral immunity, and coherently, in reducing clinical/radiological relapses, but still, they perform poorly in preventing disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6010b231d9920b8af361562008555c4f
https://doi.org/10.1097/wco.0000000000000818
https://doi.org/10.1097/wco.0000000000000818