Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Bruce Clapham"'
Autor:
Wilson Noel S, Gagandeep Somal, Michael Z. Hoemann, Don Konopacki, Maria A. Argiriadi, Anil Vasudevan, David B. Duignan, Bruce Clapham, David Banach, Phil B. Cox, Andrew Burchat, David J. Calderwood
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:5562-5567
A series of furano[3,2-d]pyrimidine Syk inhibitors were synthesized and optimized for their enzyme potency and selectivity versus other kinases. In addition, ADME properties were assessed and compounds were prepared with optimized profiles for in viv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9516261e3731d757da98b64f609b1a0f
https://doi.org/10.1016/j.bmcl.2016.09.077
https://doi.org/10.1016/j.bmcl.2016.09.077
Autor:
Philip R. Kym, Arthur Gomtsyan, Gregory A. Gfesser, Bin Li, Regina M. Reilly, Bruce Clapham, Jerome F. Daanen, Rodger F. Henry, Torben R. Neelands, Pamela S. Puttfarcken, Susan M. Huang, Robert G. Schmidt, Robert J. Altenbach, S.K. Joshi, Huaqing Liu, Marlon D. Cowart, David N. Whittern, Phil B. Cox, Jill-Desiree Brederson, Michael J. Dart, Anurupa Shrestha, Donna Gauvin, Michael E. Kort, Erol K. Bayburt, Ping Song, Steve McGaraughty, Connie R. Faltynek, Heath A. McDonald, Patricia N. Banfor, Diana Schmidt, Eric A. Voight, Mohamad Shebley, Jason A. Segreti
Publikováno v:
Journal of Medicinal Chemistry. 59:4926-4947
Transient receptor potential vanilloid 3 (TRPV3) is a Ca(2+)- and Na(+)-permeable channel with a unique expression pattern. TRPV3 is found in both neuronal and non-neuronal tissues, including dorsal root ganglia, spinal cord, and keratinocytes. Recen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd1b773984159dd5e2a719a0398228e6
https://doi.org/10.1021/acs.jmedchem.6b00287
https://doi.org/10.1021/acs.jmedchem.6b00287
Autor:
Jeffrey Y. Pan, Bruce Clapham, David M Dingle, David P Blanchard, Daryl R. Sauer, Melissa J. Michmerhuizen, Thomas A. Nemcek, Wilson Noel S
Publikováno v:
Journal of Combinatorial Chemistry. 10:88-93
This manuscript details the construction of a fully automated flow hydrogenation apparatus for use in high-throughput organic synthesis. The instrument comprises of a Bohdan robot platform coupled with a ThalesNano H-cube hydrogenator and a series of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::460aa020e67597dcc1de17b61e0117bf
https://doi.org/10.1021/cc700178a
https://doi.org/10.1021/cc700178a
Publikováno v:
Tetrahedron Letters. 46:5495-5498
The preparation of Wang resin bound α-diazo-β-ketoesters is described. These highly useful intermediates were used for the synthesis of a series of heterocycle libraries, which were obtained from the resin using TFA cleavage. In addition, a novel r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6eadde744159eb5cbef7c03a119918b8
https://doi.org/10.1016/j.tetlet.2005.06.061
https://doi.org/10.1016/j.tetlet.2005.06.061
Autor:
Kim D. Janda, Kazuhiro Yoshida, Guido Koch, Bruce Clapham, Hana Matsushita, Sang-Hyeup Lee, Juerg Zimmermann
Publikováno v:
The Journal of Organic Chemistry. 69:8829-8835
Primary ureas have been used as substrates in rhodium-catalyzed N-H insertion reactions with an array of diazocarbonyls. The insertion reaction is efficient and gives excellent selectivity and yields. The products from the insertion reaction with dia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d18fe04a62e48b6793932921365ce4d
https://doi.org/10.1021/jo048353u
https://doi.org/10.1021/jo048353u
Autor:
Jürg Zimmermann, Guido Koch, Bruce Clapham,† and, Hana Matsushita, Kim D. Janda, Sang-Hyeup Lee
Publikováno v:
Journal of Combinatorial Chemistry. 6:822-827
The solid-phase synthesis of a library of di-, tri-, and tetrasubstituted ureas is described. In this approach, an array of polymer-bound carbamates was synthesized. These polymer-bound primary and secondary amine carbamates were then treated under "
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0284191a46a9390afd289db4c051b09c
https://doi.org/10.1021/cc049916i
https://doi.org/10.1021/cc049916i
Publikováno v:
The Journal of Organic Chemistry. 69:3319-3329
A series of norbornene-based resin beads were obtained by aqueous suspension ring-opening metathesis polymerization (ROMP) and used as polymeric supports for organic synthesis. These resins were prepared from norbornene, norborn-2-ene-5-methanol, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab8fe5a35d2e79e43bb93a734a76e08c
https://doi.org/10.1021/jo049827s
https://doi.org/10.1021/jo049827s
Publikováno v:
Tetrahedron. 60:3439-3443
The conversion of carbamates into ureas using aluminum amide complexes is reported. This reaction is a convenient method to prepare bi-, tri- and tetra-substituted ureas from carbamate-protected primary or secondary amines by reaction with primary or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::235884f882a7f133b3d12494ebaadaca
https://doi.org/10.1016/j.tet.2004.02.034
https://doi.org/10.1016/j.tet.2004.02.034
Publikováno v:
Tetrahedron Letters. 45:313-316
The preparation of an array of benzimidazoles and benzothiazoles from polymer-bound esters is described. Polymer-bound esters were treated with 2-aminothiophenols or 1,2-phenylenediamines in the presence of a Lewis acid to afford the corresponding be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bd7b474b3db4efb745bddaa51d36e76
https://doi.org/10.1016/j.tetlet.2003.10.168
https://doi.org/10.1016/j.tetlet.2003.10.168
Publikováno v:
Journal of Combinatorial Chemistry. 5:188-196
A solid-phase synthesis of an array of indoles is reported. The key step in our approach involves a N-H insertion reaction of N-alkylanilines into a highly reactive polymer-bound rhodium carbenoid intermediate to yield the corresponding alpha-arylami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::531294b78c1a9bbb13660cf67944a46b
https://doi.org/10.1021/cc020079z
https://doi.org/10.1021/cc020079z