Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Bruce Clapham"'
Autor:
Wilson Noel S, Gagandeep Somal, Michael Z. Hoemann, Don Konopacki, Maria A. Argiriadi, Anil Vasudevan, David B. Duignan, Bruce Clapham, David Banach, Phil B. Cox, Andrew Burchat, David J. Calderwood
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:5562-5567
A series of furano[3,2-d]pyrimidine Syk inhibitors were synthesized and optimized for their enzyme potency and selectivity versus other kinases. In addition, ADME properties were assessed and compounds were prepared with optimized profiles for in viv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9516261e3731d757da98b64f609b1a0f
https://doi.org/10.1016/j.bmcl.2016.09.077
https://doi.org/10.1016/j.bmcl.2016.09.077
Autor:
Philip R. Kym, Arthur Gomtsyan, Gregory A. Gfesser, Bin Li, Regina M. Reilly, Bruce Clapham, Jerome F. Daanen, Rodger F. Henry, Torben R. Neelands, Pamela S. Puttfarcken, Susan M. Huang, Robert G. Schmidt, Robert J. Altenbach, S.K. Joshi, Huaqing Liu, Marlon D. Cowart, David N. Whittern, Phil B. Cox, Jill-Desiree Brederson, Michael J. Dart, Anurupa Shrestha, Donna Gauvin, Michael E. Kort, Erol K. Bayburt, Ping Song, Steve McGaraughty, Connie R. Faltynek, Heath A. McDonald, Patricia N. Banfor, Diana Schmidt, Eric A. Voight, Mohamad Shebley, Jason A. Segreti
Publikováno v:
Journal of Medicinal Chemistry. 59:4926-4947
Transient receptor potential vanilloid 3 (TRPV3) is a Ca(2+)- and Na(+)-permeable channel with a unique expression pattern. TRPV3 is found in both neuronal and non-neuronal tissues, including dorsal root ganglia, spinal cord, and keratinocytes. Recen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd1b773984159dd5e2a719a0398228e6
https://doi.org/10.1021/acs.jmedchem.6b00287
https://doi.org/10.1021/acs.jmedchem.6b00287
Publikováno v:
Tetrahedron Letters. 46:5495-5498
The preparation of Wang resin bound α-diazo-β-ketoesters is described. These highly useful intermediates were used for the synthesis of a series of heterocycle libraries, which were obtained from the resin using TFA cleavage. In addition, a novel r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6eadde744159eb5cbef7c03a119918b8
https://doi.org/10.1016/j.tetlet.2005.06.061
https://doi.org/10.1016/j.tetlet.2005.06.061
Publikováno v:
The Journal of Organic Chemistry. 69:3319-3329
A series of norbornene-based resin beads were obtained by aqueous suspension ring-opening metathesis polymerization (ROMP) and used as polymeric supports for organic synthesis. These resins were prepared from norbornene, norborn-2-ene-5-methanol, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab8fe5a35d2e79e43bb93a734a76e08c
https://doi.org/10.1021/jo049827s
https://doi.org/10.1021/jo049827s
Publikováno v:
Tetrahedron. 60:3439-3443
The conversion of carbamates into ureas using aluminum amide complexes is reported. This reaction is a convenient method to prepare bi-, tri- and tetra-substituted ureas from carbamate-protected primary or secondary amines by reaction with primary or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::235884f882a7f133b3d12494ebaadaca
https://doi.org/10.1016/j.tet.2004.02.034
https://doi.org/10.1016/j.tet.2004.02.034
Publikováno v:
Tetrahedron Letters. 45:313-316
The preparation of an array of benzimidazoles and benzothiazoles from polymer-bound esters is described. Polymer-bound esters were treated with 2-aminothiophenols or 1,2-phenylenediamines in the presence of a Lewis acid to afford the corresponding be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bd7b474b3db4efb745bddaa51d36e76
https://doi.org/10.1016/j.tetlet.2003.10.168
https://doi.org/10.1016/j.tetlet.2003.10.168
Publikováno v:
Journal of Combinatorial Chemistry. 5:188-196
A solid-phase synthesis of an array of indoles is reported. The key step in our approach involves a N-H insertion reaction of N-alkylanilines into a highly reactive polymer-bound rhodium carbenoid intermediate to yield the corresponding alpha-arylami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::531294b78c1a9bbb13660cf67944a46b
https://doi.org/10.1021/cc020079z
https://doi.org/10.1021/cc020079z
Publikováno v:
Organic Letters. 5:511-514
[reaction: see text] The solution and solid-phase synthesis of imidazolones is reported. The key step for the preparation of these compounds is the N-H insertion reaction of primary ureas into highly reactive rhodium carbenoid intermediates. Typicall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e7ffda2703846b614a259ff559f0718
https://doi.org/10.1021/ol020244j
https://doi.org/10.1021/ol020244j
Publikováno v:
Tetrahedron Letters. 43:5407-5410
A series of diverse polymer bound β-ketoesters have been prepared using a transesterification reaction between t-butyl β-ketoesters and a hydroxybutyl functionalized JandaJel resin. Additionally, these highly useful polymer bound substrates have al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1429cd2bba8dcd4484d30b375d9a92f
https://doi.org/10.1016/s0040-4039(02)01076-6
https://doi.org/10.1016/s0040-4039(02)01076-6
Publikováno v:
The Journal of Organic Chemistry. 67:3045-3050
A series of soluble microgel polymers have been synthesized using solution-phase polymerization reactions. In a systematic manner, several variables such as monomer concentration, cross-linker content, reaction solvent and reaction time were examined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8fe7758b3ba1e2be392b36dc47c32b4
https://doi.org/10.1021/jo016362m
https://doi.org/10.1021/jo016362m