Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Bruce Charles Baguley"'
Publikováno v:
Frontiers in Oncology, Vol 4 (2014)
High intravenous doses of vitamin C (ascorbic acid) have been reported to benefit cancer patients but the data are controversial and there is incomplete knowledge of what physiological mechanisms might be involved in any response. Vitamin C is taken
Externí odkaz:
https://doaj.org/article/d14c82020efb4f0ea71c3ea59647715b
Autor:
Herah eHansji, Euphemia Yee Leung, Bruce Charles Baguley, Graeme eFInlay, Marjan Effat Askarian-Amiri
Publikováno v:
Frontiers in Genetics, Vol 5 (2014)
The majority of the human genome is transcribed, even though only 2% of transcripts encode proteins. Non-coding transcripts were originally dismissed as evolutionary junk or transcriptional noise, but with the development of whole genome technologies
Externí odkaz:
https://doaj.org/article/486743b7ca064625ada836e0bcf30360
Autor:
Euphemia Yee Leung, Ji Eun eKim, Marjan eAskarian-Amiri, Wayne R Joseph, Mark J McKeage, Bruce Charles Baguley
Publikováno v:
Frontiers in Oncology, Vol 4 (2014)
The mTOR pathway is a key regulator of multiple cellular signaling pathways and is a potential target for therapy. We have previously developed two hormone-resistant sub-lines of the MCF-7 human breast cancer line, designated TamC3 and TamR3, which w
Externí odkaz:
https://doaj.org/article/02f98dd27c274e06a924a795a808a585
Autor:
Anshul eAwasthi, Adele G Woolley, Fabienne J Lecomte, Noelyn eHung, Bruce Charles Baguley, Sigurd M Wilbanks, Aaron R Jeffs, Joel David Alan Tyndall
Publikováno v:
Frontiers in Oncology, Vol 3 (2013)
GLI pathogenesis-related 1 (GLIPR1) was previously identified as an epigentically regulated tumour suppressor in prostate cancer and, conversely, an oncoprotein in glioma. More recently, GLIPR1 was shown to be differentially expressed in other cancer
Externí odkaz:
https://doaj.org/article/f08650053a7a42fe9c540f4abb4895b2
Autor:
Clare Judith Stones, Ji Eun eKim, Wayne Robert Joseph, Elaine Shirley Marshall, Euphemia eLeung, Graeme John Finlay, Andrew Neil Shelling, Bruce Charles Baguley
Publikováno v:
Frontiers in Genetics, Vol 4 (2013)
The NRAS and BRAF genes are frequently mutated in melanoma, suggesting that the NRAS-BRAF-MEK-ERK signalling pathway is an important target for therapy. Two classes of drugs, one targeting activated BRAF and one targeting MEK, are currently undergoin
Externí odkaz:
https://doaj.org/article/0ec4ab47df344ebeb002ce5d4579e55c
Publikováno v:
Frontiers in Genetics, Vol 4 (2013)
The epithelial-mesenchymal transition (EMT) describes a reversible switch from an epithelial-like to a mesenchymal-like phenotype. It is essential for the development of the normal epithelium and also contributes to the invasive properties of carcino
Externí odkaz:
https://doaj.org/article/2ea6710ba35a49f3b6dd41183a130f1c
Publikováno v:
Frontiers in Oncology, Vol 3 (2013)
The Hippo signalling pathway comprises a series of cytoplasmic tumour suppressor proteins including Merlin and the Lats1/2 and MST1/2 kinases, and is thought to play a critical role in determining the sizes of organs and tissues. The Hippo pathway is
Externí odkaz:
https://doaj.org/article/12649a0c02da41e683d5b8eb914c1ed9
Autor:
Leslie W. Deady, William Alexander Denny, Anthony J. Kaye, Bruce Charles Baguley, Graeme J. Finlay
Publikováno v:
Journal of Medicinal Chemistry. 40:2040-2046
A series of tetracyclic quinoline- and quinoxalinecarboxamides were prepared, and their cytotoxicities were evaluated in a series of murine human tumor cell lines. Most of the quinoline derivatives were prepared by an adaptation of the Pfitzinger syn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0e13baf3fd69584eb3f711f4b346dd8
https://doi.org/10.1021/jm970044r
https://doi.org/10.1021/jm970044r
Publikováno v:
ChemInform. 25
A series of azaacridine (benzonaphthyridine) analogues of the drug N-[2-(dimethylamino)ethyl]-acridine-4-carboxamide (DACA) (currently in clinical trial) were synthesized. These compounds showed DNA binding affinities similar to that of DACA, as dete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e80a50b7ba406bc785a63ec83ea5018a
https://doi.org/10.1002/chin.199427150
https://doi.org/10.1002/chin.199427150
Autor:
William Alexander Denny, Anthony J. Kaye, Leslie W. Deady, Graeme J. Finlay, Bruce Charles Baguley
Publikováno v:
ChemInform. 28
A series of tetracyclic quinoline- and quinoxalinecarboxamides were prepared, and their cytotoxicities were evaluated in a series of murine human tumor cell lines. Most of the quinoline derivatives were prepared by an adaptation of the Pfitzinger syn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::beec63dac8815532100cf0ed4b27a22d
https://doi.org/10.1002/chin.199741183
https://doi.org/10.1002/chin.199741183