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pro vyhledávání: '"Bruce Chang-Gu"'
Autor:
Mark L. Sowers, James W. Conrad, Bruce Chang-Gu, Ellie Cherryhomes, Linda C. Hackfeld, Lawrence C. Sowers
Publikováno v:
Molecules, Vol 28, Iss 3, p 970 (2023)
Although genomic DNA is predominantly duplex under physiological conditions, particular sequence motifs can favor the formation of alternative secondary structures, including the G-quadruplex. These structures can exist within gene promoters, telomer
Externí odkaz:
https://doaj.org/article/a33412c3fbe443a6b6675c6400251f67
Autor:
Tuvshintugs Baljinnyam, James W. Conrad, Mark L. Sowers, Bruce Chang-Gu, Jason L. Herring, Linda C. Hackfeld, Kangling Zhang, Lawrence C. Sowers
Publikováno v:
Chemical Research in Toxicology. 36:162-176
Publikováno v:
Methods
G-quadruplex structures (G4s) form readily in DNA and RNA and play diverse roles in gene expression and other processes, and their inappropriate formation and stabilization are linked to human diseases. G4s are inherently long-lived, such that their
Publikováno v:
Biol Chem
DHX36 is a eukaryotic DEAH/RHA family helicase that disrupts G-quadruplex structures (G4s) with high specificity, contributing to regulatory roles of G4s. Here we used a DHX36 truncation to examine the roles of the 13-amino acid DHX36-specific motif