Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Bruce Carpick"'
Autor:
Kristen Kalbfleisch, Sasmit Deshmukh, Carmen Mei, Moriam Ore, Wayne Williams, Ibrahim Durowoju, Jessica Duprez, Sylvie Morin, Bruce Carpick, Marina Kirkitadze
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 17, Iss , Pp 14-20 (2019)
Purpose: The goal of this study is to set an empirical baseline to map the structure-function relation of the antigens from the commercialized vaccine products. Methods: To study the structural changes of protein antigens after adsorption several ana
Externí odkaz:
https://doaj.org/article/59cb11c9209845ce934473361a9087cc
Autor:
Carmen Mei, Sasmit Deshmukh, James Cronin, Shuxin Cong, Daniel Chapman, Nicole Lazaris, Liliana Sampaleanu, Ulrich Schacht, Katherine Drolet-Vives, Moriam Ore, Sylvie Morin, Bruce Carpick, Matthew Balmer, Marina Kirkitadze
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 17, Iss , Pp 1184-1194 (2019)
Purpose: Aluminum-based adjuvants including aluminum phosphate (AlPO4) are commonly used in many human vaccines to enhance immune response. The interaction between the antigen and adjuvant, including the physical adsorption of antigen, may play a rol
Externí odkaz:
https://doaj.org/article/027dd679e94c405880b32f10cfecb4ac
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 15, Iss , Pp 14-20 (2017)
This study describes the NMR-based method to determine the limit of quantitation (LOQ) and limit of detection (LOD) of cholesterol, a process-related impurity in the replication-deficient Herpes Simplex Virus (HSV) type 2 candidate vaccine HSV529. Th
Externí odkaz:
https://doaj.org/article/757898d02ea544e994b1949ecf3712a1
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 14, Iss C, Pp 154-160 (2016)
Bacille Calmette–Guerin, BCG, is a live attenuated bovine tubercle bacillus used for the treatment of non-muscle invasive bladder cancer. In this study, an Electrical Sensing Zone (ESZ) method was developed to measure the particle count and the siz
Externí odkaz:
https://doaj.org/article/b0f5a06327d5468ab762b76acadc07c9
Autor:
Eric Abachin, Melissa Vanhamme, Alexandre Dobly, Sylvie Uhlrich, Celine Vanhee, Raphael Esson, Jean-François Dierick, Bruce Carpick, Antoine Francotte
The tetanus neurotoxin (TeNT) is one of the most toxic proteins known to man, which prior to the use of the vaccine against the TeNT producing bacteria Clostridium tetani, resulted in a 20 % mortality rate upon infection. The clinical detrimental eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8454c9af160e211f93691176307690e
Autor:
Ulrich Schacht, Carmen Mei, Liliana M. Sampaleanu, Nicole Lazaris, Marina Kirkitadze, Shuxin Cong, James Cronin, Matthew Balmer, Sylvie Morin, Daniel Chapman, Sasmit S. Deshmukh, Katherine Drolet-Vives, Moriam O. Ore, Bruce Carpick
Publikováno v:
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 17, Iss, Pp 1184-1194 (2019)
Computational and Structural Biotechnology Journal, Vol 17, Iss, Pp 1184-1194 (2019)
Purpose Aluminum-based adjuvants including aluminum phosphate (AlPO4) are commonly used in many human vaccines to enhance immune response. The interaction between the antigen and adjuvant, including the physical adsorption of antigen, may play a role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2a91b17231a1a8e219974b19a3d4b8a
https://doi.org/10.1016/j.csbj.2019.08.003
https://doi.org/10.1016/j.csbj.2019.08.003
Autor:
Shaolong Zhu, Peter Liuni, Bruce Carpick, D. Andrew James, Tricia Chen, Luciano Ettorre, Jason Szeto, Derek J. Wilson
Publikováno v:
Biochemistry. 58:646-656
The diphtheria toxoid (DT) antigen is one of the major components in pediatric and booster combination vaccines and is known to raise a protective humoral immune response upon vaccination. However, a structurally resolved analysis of diphtheria toxin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c36f847edb6d75185efe75b958a1dbbc
https://doi.org/10.1021/acs.biochem.8b01123
https://doi.org/10.1021/acs.biochem.8b01123
Autor:
Kristen Kalbfleisch, Wayne Williams, Jessica Duprez, Bruce Carpick, Ibrahim Durowoju, Marina Kirkitadze, Moriam Ore, Sasmit S. Deshmukh, Sylvie Morin, Carmen Mei
Publikováno v:
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 17, Iss, Pp 14-20 (2019)
Computational and Structural Biotechnology Journal, Vol 17, Iss, Pp 14-20 (2019)
Purpose The goal of this study is to set an empirical baseline to map the structure-function relation of the antigens from the commercialized vaccine products. Methods To study the structural changes of protein antigens after adsorption several analy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a83198cc939aa5e6ebfdb2610bac5a
http://europepmc.org/articles/PMC6297905
http://europepmc.org/articles/PMC6297905
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 159:166-172
A novel qNMR method is described for the quantitative determination of total aluminum and phosphate in aluminum phosphate (AlPO4) adjuvanted vaccine samples using solution 27Al and 31P nuclear magnetic resonance (NMR) spectroscopy. External standard
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b4a55a81f44eebd74f039382dbb0229
https://doi.org/10.1016/j.jpba.2018.06.025
https://doi.org/10.1016/j.jpba.2018.06.025
Autor:
Laurent Thion, Audrey Toinon, Beata Gajewska, Sylvie Uhlrich, Nolwenn Nougarede, Christelle Fontaine, Bruce Carpick
Publikováno v:
Biologicals. 54:1-7
Background Recombinant proteins expressed in host cell systems may contain host cell proteins (HCP) as impurities. While there is no clear evidence of clinical adverse events attributable to HCP, HCP levels and profiles must be documented to meet reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35a9634f1254eae22cb7ce1fa8086364
https://doi.org/10.1016/j.biologicals.2018.05.006
https://doi.org/10.1016/j.biologicals.2018.05.006