Narrow microtunnel technology for the isolation and precise identification of axonal communication among distinct hippocampal subregion networks.

Autor: Udit Narula, Andres Ruiz, McKinley McQuaide, Thomas B DeMarse, Bruce C Wheeler, Gregory J Brewer

Publikováno v: PLoS ONE, Vol 12, Iss 5, p e0176868 (2017)

Communication between different sub regions of the hippocampus is fundamental to learning and memory. However accurate knowledge about information transfer between sub regions from access to the activity in individual axons is lacking. MEMS devices w

Externí odkaz: https://doaj.org/article/0299f10e90304692b6e2dd038362f375

Healthcare Innovations to Address the Challenges of the COVID-19 Pandemic

Autor: Metin Akay, Shankar Subramaniam, Colin Brennan, Paolo Bonato, Charlotte Mae K. Waits, Bruce C. Wheeler, Dimitrios I. Fotiadis

Publikováno v: IEEE journal of biomedical and health informatics. 26(7)

We have been faced with an unprecedented challenge in combating the COVID-19/SARS-CoV2 outbreak that is threatening the fabric of our civilization, causing catastrophic human losses and a tremendous economic burden globally. During this difficult tim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::648513b7f47b46d3dc40a27b82f1b4cc
https://pubmed.ncbi.nlm.nih.gov/35077374

Toward a self-wired active reconstruction of the hippocampal trisynaptic loop: DG-CA3

Autor: Gregory J. Brewer, Michael D. Boehler, Stathis eLeondopulos, Liangbin ePan, Sankaraleengam eAlagapan, Thomas eDeMarse, Bruce C Wheeler

Publikováno v: Frontiers in Neural Circuits, Vol 7 (2013)

The mammalian hippocampus functions to encode and retrieve memories by transiently changing synaptic strengths, yet encoding in individual subregions for transmission between regions remains poorly understood. Toward the goal of better understanding

Externí odkaz: https://doaj.org/article/1a9f08562ff94a2780bc40a2392d05d8

Current and Future Challenges in Point-of-Care Technologies: A Paradigm-Shift in Affordable Global Healthcare With Personalized and Preventive Medicine

Autor: Martin Gerber, Metin Akay, William J. Heetderks, Clifford C. Dacso, Balram Bhargava, T. Sunder, Atam P. Dhawan, Milind Shah, Nigel H. Lovell, Anurag Mairal, Bruce C. Wheeler, S. G. Senthilvel, Soumyadipta Acharya, Misha Pavel, May D. Wang

Publikováno v: IEEE Journal of Translational Engineering in Health and Medicine
IEEE Journal of Translational Engineering in Health and Medicine, Vol 3, Pp 1-10 (2015)

This paper summarizes the panel discussion at the IEEE Engineering in Medicine and Biology Point-of-Care Healthcare Technology Conference (POCHT 2013) held in Bangalore India from Jan 16–18, 2013. Modern medicine has witnessed interdisciplinary tec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d614562cab95a2622ec571241fae3103
https://doi.org/10.1109/jtehm.2015.2400919

Sparse and Specific Coding during Information Transmission between Co-cultured Dentate Gyrus and CA3 Hippocampal Networks

Autor: Daniele Poli, Bruce C. Wheeler, Gregory J. Brewer, Thomas B. DeMarse, Srikanth Thiagarajan

Publikováno v: Frontiers in Neural Circuits

To better understand encoding and decoding of stimulus information in two specific hippocampal sub-regions, we isolated and co-cultured rat primary dentate gyrus (DG) and CA3 neurons within a two-chamber device with axonal connectivity via micro-tunn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::798373de483df6c832d8159ec54fcb21
https://doi.org/10.3389/fncir.2017.00013