Equine grass sickness (a multiple systems neuropathy) is associated with alterations in the gastrointestinal mycobiome

Autor: Bruce C. McGorum, Zihao Chen, Laura Glendinning, Hyun S. Gweon, Luanne Hunt, Alasdair Ivens, John A. Keen, R. Scott Pirie, Joanne Taylor, Toby Wilkinson, Gerry McLachlan

Publikováno v: Animal Microbiome, Vol 3, Iss 1, Pp 1-15 (2021)

Abstract Background Equine grass sickness (EGS) is a multiple systems neuropathy of grazing horses of unknown aetiology. An apparently identical disease occurs in cats, dogs, rabbits, hares, sheep, alpacas and llamas. Many of the risk factors for EGS

Externí odkaz: https://doaj.org/article/a2d77d2e792d4bf695a5161262b441b5

Establishment of a model for equine small intestinal disease: effects of extracorporeal blood perfusion of equine ileum on metabolic variables and histological morphology – an experimental ex vivo study

Autor: Maria S. Unterköfler, Bruce C. McGorum, Elspeth M. Milne, Theresia F. Licka

Publikováno v: BMC Veterinary Research, Vol 15, Iss 1, Pp 1-12 (2019)

Abstract Background In horses a number of small intestinal diseases is potentially life threatening. Among them are Equine Grass Sickness (EGS), which is characterised by enteric neurodegeneration of unknown aetiology, as well as reperfusion injury o

Externí odkaz: https://doaj.org/article/2b9e59d135dd434eb495daaf8d7b0808

Optical Detection of Distal Lung Enzyme Activity in Human Inflammatory Lung Disease

Autor: Alicia Megia-Fernandez, Adam Marshall, Ahsan R. Akram, Bethany Mills, Sunay V. Chankeshwara, Emma Scholefield, Amy Miele, Bruce C. McGorum, Chesney Michaels, Nathan Knighton, Tom Vercauteren, Francois Lacombe, Veronique Dentan, Annya M. Bruce, Joanne Mair, Robert Hitchcock, Nik Hirani, Chris Haslett, Mark Bradley, Kevin Dhaliwal

Publikováno v: BME Frontiers, Vol 2021 (2021)

Objective and Impact Statement. There is a need to develop platforms delineating inflammatory biology of the distal human lung. We describe a platform technology approach to detect in situ enzyme activity and observe drug inhibition in the distal hum

Externí odkaz: https://doaj.org/article/a1b6469c03914e899bda822a8f0334af

The effect of season, management and endocrinopathies on vitamin D status in horses

Autor: Miranda C. M. C. Dosi, Bruce C. McGorum, Roxane D. Kirton, Eugenio Cillán‐García, Richard J. Mellanby, John A. Keen, Emma A. Hurst, Ruth A. Morgan

Publikováno v: Dosi, M, McGorum, B, Kirton, R D, Cillan-Garcia, E, Mellanby, R, Keen, J, Hurst, E & Morgan, R 2023, ' The effect of season, management and endocrinopathies on vitamin D status in horses ', Equine Veterinary Journal, vol. 55, no. 4, pp. 672-680 . https://doi.org/10.1111/evj.13873

BackgroundVitamin D deficiency is common in humans and is increasingly linked to the pathogenesis of a multitude of diseases including obesity and metabolic syndrome. The biology of vitamin D in horses is poorly described; the relative contribution o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f18e0d0b9e6bba734f18e1a273b0f12
https://doi.org/10.1111/evj.13873

Equine Dysautonomia

Autor: Bruce C, McGorum, R Scott, Pirie

Publikováno v: McGorum, B C & Pirie, R S 2018, ' Equine Dysautonomia ', Veterinary Clinics of North America: Equine Practice, vol. 34, no. 1, pp. 113-125 . https://doi.org/10.1016/j.cveq.2017.11.010

Equine dysautonomia (ED; also known as equine grass sickness) is a neurological disease of unknown cause, which primarily affects grazing adult horses. The clinical signs reflect degeneration of specific neuronal populations, predominantly within the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d689eae86f9200e9cef8cc95f4c2405b
https://www.pure.ed.ac.uk/ws/files/57993018/AAM.pdf