Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Bruce C McKay"'
Publikováno v:
Data in Brief, Vol 42, Iss , Pp 108126- (2022)
Isoginkgetin (IGG) is a compound originally derived from the leaves of Ginkgo biloba trees. It was subsequently identified through a chemical screen to be an inhibitor of both the major and minor spliceosome, with an IC50 value of 30 µM [1]. Little
Externí odkaz:
https://doaj.org/article/5793fca4667249e08ac76f4778abef03
Autor:
Erin J Vanzyl, Hadil Sayed, Alex B Blackmore, Kayleigh R C Rick, Pasan Fernando, Bruce C McKay
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0224953 (2020)
The spliceosome assembles on pre-mRNA in a stepwise manner through five successive pre-spliceosome complexes. The spliceosome functions to remove introns from pre-mRNAs to generate mature mRNAs that encode functional proteins. Many small molecule inh
Externí odkaz:
https://doaj.org/article/90ec183a8f8c474faf2968abd8490439
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Activating transcription factor 4 (ATF4) plays a central role in the integrated stress response (ISR) and one overlapping branch of the unfolded protein response (UPR). We recently reported that the splicing inhibitor isoginkgetin (IGG) indu
Externí odkaz:
https://doaj.org/article/f679efd2f57748fdb7b42e9d9ec0a6f5
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0191178 (2018)
The spliceosome is a large ribonucleoprotein complex that catalyzes the removal of introns from RNA polymerase II-transcribed RNAs. Spliceosome assembly occurs in a stepwise manner through specific intermediates referred to as pre-spliceosome complex
Externí odkaz:
https://doaj.org/article/29dbe8cccebf4e7cadf265d66c81b6d3
Autor:
Miguel A Cabrita, Erin J Vanzyl, Jeff D Hamill, Elysia Pan, Kristen A Marcellus, Victoria J Tolls, Rhea C Alonzi, Alyssa Pastic, Teeghan M E Rambo, Hadil Sayed, Bruce C McKay
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0148529 (2016)
The p53 tumour suppressor is a transcription factor that can regulate the expression of numerous genes including many encoding proteins and microRNAs (miRNAs). The predominant outcomes of a typical p53 response are the initiation of apoptotic cascade
Externí odkaz:
https://doaj.org/article/b1da1bea028b4c7dad446748d71f8161
Autor:
Christian Brochu, Miguel A Cabrita, Brian D Melanson, Jeffrey D Hamill, Rosanna Lau, M A Christine Pratt, Bruce C McKay
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57426 (2013)
The cold inducible RNA binding protein (CIRBP) responds to a wide array of cellular stresses, including short wavelength ultraviolet light (UVC), at the transcriptional and post-translational level. CIRBP can bind the 3'untranslated region of specifi
Externí odkaz:
https://doaj.org/article/336b4d24a8814229997c53e69a9a455d
Publikováno v:
PeerJ, Vol 11, p e16683 (2023)
Background Thapsigargin (Tg) is a compound that inhibits the SERCA calcium transporter leading to decreased endoplasmic reticulum (ER) Ca2+ levels. Many ER chaperones are required for proper folding of membrane-associated and secreted proteins, and t
Externí odkaz:
https://doaj.org/article/a6ace64f6cce496a8a154ec10fac51ba
Autor:
M.A. Christine Pratt, Tony Durst, James S. Wright, Leigh C. Murphy, Bruce C. McKay, Chelsea McGregor, Miguel A. Cabrita, Rosanna Lau, Samantha C. Ruddy
PDF - 130K, Effects of tamoxifen and fulvestrant on LCC9 and MCF-7 cell proliferation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f97be605e189e9892c46ab3107969fc
https://doi.org/10.1158/1535-7163.22501116
https://doi.org/10.1158/1535-7163.22501116
Autor:
M.A. Christine Pratt, Tony Durst, James S. Wright, Leigh C. Murphy, Bruce C. McKay, Chelsea McGregor, Miguel A. Cabrita, Rosanna Lau, Samantha C. Ruddy
PDF - 154K, Effects of ER ligands on cell cycle in MCF-7 and LCC9 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::068284d2079bc4c104d7d5adffe80aa9
https://doi.org/10.1158/1535-7163.22501113
https://doi.org/10.1158/1535-7163.22501113
Autor:
M.A. Christine Pratt, Tony Durst, James S. Wright, Leigh C. Murphy, Bruce C. McKay, Chelsea McGregor, Miguel A. Cabrita, Rosanna Lau, Samantha C. Ruddy
PDF - 84K, ERalpha knockdown in ERbeta overexpressing cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc560602cc86de5a6d26dbff36f6d4a6
https://doi.org/10.1158/1535-7163.22501107.v1
https://doi.org/10.1158/1535-7163.22501107.v1