Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Bruce A. Thornburgh"'
Autor:
F. Barclay Shilliday, Xiaojun Fang, Chungang Gu, Daniel P. Walker, Gwendolyn D. Fate, Bruce A. Thornburgh, J. Scott Daniels
Publikováno v:
Drug Metabolism Letters. 4:163-172
The quinuclidine PHA-0568487(1) is an agonist of the alpha 7 nicotinic acetylcholine receptor that was designed to mitigate the bioactivation associated with the core scaffold and subsequently remove associated liabilities with in vivo tolerability.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4e777b592b0219f5ae9e7adaf437509
https://doi.org/10.2174/187231210791698429
https://doi.org/10.2174/187231210791698429
Autor:
Raymond S. Hurst, Bruce N. Rogers, Mihály Hajós, Rodney R. Walters, Donn G. Wishka, Brian A. Staton, David W. Piotrowski, Brad A. Acker, Kai S. Li, Michael Krause, Vincent E. Groppi, William E. Hoffmann, Daniel P. Walker, Barbara A. Olson, Laura Fitzgerald, E. Jon Jacobsen, Thomas J. Raub, Mark L. Wolfe, Bruce A. Thornburgh, Paula M. Tinholt, Steven Charles Reitz, Jason K. Myers
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:3611-3615
A novel α7 nAChR agonist, N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide (3a, PHA-709829), has been identified for the potential treatment of cognitive deficits in schizophrenia. The compound shows potent and selective α7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4401b56d4c1dc535fb66dd987f2e99f3
https://doi.org/10.1016/j.bmcl.2008.04.070
https://doi.org/10.1016/j.bmcl.2008.04.070
Autor:
Daniel P. Walker, Barbara A. Olson, Fusen Han, E. Jon Jacobsen, Raymond S. Hurst, Shaojuan Jia, Lester A. Dolak, Brandon J. Margolis, Nicole R. Higdon, Tatiana N. Vetman, David W. Piotrowski, Brian A. Staton, Matthew R. Hester, Luz A. Cortes-Burgos, Erik H. F. Wong, Theron M. Wall, Steven Charles Reitz, Vincent E. Groppi, Bruce N. Rogers, Kai S. Li, Brad A. Acker, Bruce A. Thornburgh, Paula M. Tinholt, Jason K. Myers, Mihály Hajós, Thomas J. Raub, Mark L. Wolfe, Karen M. Yates, William E. Hoffmann, Laura Fitzgerald, Donn G. Wishka, Eric P. Seest, Rodney R. Walters
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:8219-8248
A novel set of azabicyclic aryl amides have been identified as potent and selective agonists of the alpha7 nAChR. A two-pronged approach was taken to improve the potential hERG liability of previously disclosed alpha7 nAChR agonist, PNU-282,987, whil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::058d11e4149544128cfd448da56d7569
https://doi.org/10.1016/j.bmc.2006.09.019
https://doi.org/10.1016/j.bmc.2006.09.019
Publikováno v:
Drug Metabolism and Disposition. 34:1615-1623
The metabolism and excretion of N-(3R)-1-azabicyclo[2.2.2]oct-3-ylfuro[2,3-c]pyridine-5-carboxamide (1), an agonist of the alpha7 nicotinic acetylcholinergic receptor, were determined in both Sprague-Dawley rats and beagle dogs using [3H]1. Initially
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f21687fac539c61dcffdfcfd984f32b
https://doi.org/10.1124/dmd.106.010934
https://doi.org/10.1124/dmd.106.010934
Autor:
Arneric Sp, Karen K. Cook, Thomas J. Raub, Bruce N. Rogers, Mark L. Wolfe, Eric Jon Jacobsen, Vincent E. Groppi, Carey G, Brian A. Staton, Daniel P. Walker, Raymond S. Hurst, Luz A. Cortes-Burgos, Rodney R. Walters, Donn G. Wishka, Theron M. Wall, Jia S, Hanchar Aj, Karen M. Yates, Steven B. Sands, Bruce A. Thornburgh, Gold Lh, Soglia, Jason K. Myers, Franklin S, Steven Charles Reitz, Sabrina X. Zhao, Amit S. Kalgutkar, Nicole R. Higdon, Olson Kl, Erik H. F. Wong, Mihály Hajós, William E. Hoffmann
Publikováno v:
Journal of Medicinal Chemistry. 49:4425-4436
N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide (14, PHA-543,613), a novel agonist of the alpha7 neuronal nicotinic acetylcholine receptor (alpha7 nAChR), has been identified as a potential treatment of cognitive deficits in sch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09fbbbb19eb89de61edd6e606a68da00
https://doi.org/10.1021/jm0602413
https://doi.org/10.1021/jm0602413
Publikováno v:
Canadian journal of biochemistry. 56(8)
A procedure for the purification of Escherichia coli phosphofructokinase by affinity chromatography is described. The results of amino acid analyses of the purified protein and tryptic peptide mapping suggest that the tetrameric phosphofructokinase i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af5e98292635cdf9c34e7a9d076500ef
https://pubmed.ncbi.nlm.nih.gov/150935
https://pubmed.ncbi.nlm.nih.gov/150935