Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Bruce A. Steinbaugh"'
Autor:
Bradley Dean Tait, H. William Tedford, Chad A. Finkenbinder, Gary L. Benzon, Bruce A. Steinbaugh, Whitney Smith, Anna Tempczyk-Russell, Lin Bao, Robert M. Kennedy
Publikováno v:
Pesticide Biochemistry and Physiology. 106:124-140
Previously, scanning mutagenesis studies of the insecticidal peptide omega-hexatoxin-Hv1a identified a set of structural features used by the omega-hexatoxin-1 family to modulate insect calcium channels. These structural features were re-purposed as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c1f8843626551b275950f0f8e24c1c0
https://doi.org/10.1016/j.pestbp.2013.01.009
https://doi.org/10.1016/j.pestbp.2013.01.009
Autor:
Andrew Robertson, Gina Lu, Catherine Sekerke, Bruce A. Steinbaugh, Robert M. Kennedy, Scott D. Larsen, Bruce D. Roth, Mark C. Kowala, Valerie Askew, Bharat K. Trivedi, Kevin Sun, Steve Miller, Yuntao Song, Jeffrey C. Hanselman, Lisa Dillon, William Keun Chan Park, Bradley D. Tait, Bruce Auerbach, Zhiwu Lin
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(3)
4-Sulfamoyl pyrroles were designed as novel hepatoselective HMG-CoA reductase inhibitors (statins) to reduce myalgia, a statin-induced adverse effect. The compounds were prepared via a [3 + 2] cycloaddition of a Munchnone with a sulfonamide-substitut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::529bbd001cc056a0d63562fa2b448f60
https://pubmed.ncbi.nlm.nih.gov/18155906
https://pubmed.ncbi.nlm.nih.gov/18155906
Publikováno v:
Antiviral research. 52(3)
Human cytomegalovirus (HCMV) is a major opportunistic pathogen in immunocompromised individuals. Current therapies target viral DNA replication and accumulate mutations that yield cross-resistance among the approved drugs. A novel, non-nucleoside inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f2069a7165d02340017bf2386ec6750
https://pubmed.ncbi.nlm.nih.gov/11675146
https://pubmed.ncbi.nlm.nih.gov/11675146
Autor:
John R. Rubin, Neil Graham, Krishna R. Iyer, Steven VanderRoest, Elizabeth A. Lunney, Larry James Markoski, Christopher Andrew Gajda, Bradley D. Tait, James Saunders, Harriet W. Hamilton, Greg Zeikus, John M. Domagala, Stephen J. Gracheck, John W. Erickson, Alexander Pavlovsky, Christine Humblet, Donna Ferguson, J.V.N. Vara Prasad, Eric Andrew Zeikus, Edmund L. Ellsworth, Bruce A. Steinbaugh, Frederick E. Boyer, A. Urumov, Michael Sinz, Donald Hupe, Susan Elizabeth Hagen, Carolyn Nouhan, S V Gulnik, Joanne Brodfuehrer, Tod P. Holler, Peter J. Tummino
Publikováno v:
Bioorganicmedicinal chemistry. 7(12)
With the insight generated by the availability of X-ray crystal structures of various 5,6-dihydropyran-2-ones bound to HIV PR, inhibitors possessing various alkyl groups at the 6-position of 5,6-dihydropyran-2-one ring were synthesized. The inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0149491cd6b8b9d5773224b5a0e26cea
https://pubmed.ncbi.nlm.nih.gov/10658583
https://pubmed.ncbi.nlm.nih.gov/10658583
Autor:
Annette M. Doherty, Klutchko, Taylor, Michael J. Ryan, Cleo J. C. Connolly, William C. Patt, Bruce A. Steinbaugh, Harriet W. Hamilton, Sircar I, D G Taylor
Publikováno v:
Journal of medicinal chemistry. 35(14)
A series of renin inhibitors was synthesized that contained a 2-amino-4-thiazolyl moiety at the P2 position. These derivatives are potent inhibitors of monkey renin in vitro and are selective in that they only weakly inhibit the closely related aspar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::632339f245d463a8bbf23be0c751bb94
https://pubmed.ncbi.nlm.nih.gov/1635057
https://pubmed.ncbi.nlm.nih.gov/1635057
Publikováno v:
The Journal of Antibiotics. 39:372-379
The synthesis and in vitro antibacterial profile of a series of (Z)-(2-amino-4-thiazolyl)-[(2,3-dialkoxypropoxy)imino]acetyl derivatives of 7-aminocephalosporanic acid and 3-aminomonobactamic acid are reported.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1adaec02ea68715c1ce5109f87cbff0d
https://doi.org/10.7164/antibiotics.39.372
https://doi.org/10.7164/antibiotics.39.372