Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Bruce A. Pearlman"'
Publikováno v:
Tetrahedron Letters. 47:6417-6420
Si(0)/KF is introduced as a strong, inexpensive, environmentally friendly, and safe reagent for ‘dissolving metal’-type reduction. PMHS/hexamethyldisiloxane/pTSA is introduced as an inexpensive substitute for Et3SiH/TFA for ‘ionic hydrogenation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::905b06552f6ce90efb45a6aea11ba45c
https://doi.org/10.1016/j.tetlet.2006.06.136
https://doi.org/10.1016/j.tetlet.2006.06.136
Publikováno v:
Organic Process Research & Development. 10:921-926
A chromatography-free process for synthesis of 6-piperazinyl-2,4-bis-pyrrolidinylpyrimidine in isomerically pure form is described. The key step is the purification of a crude 6-chloro-2,4-bis-pyrrolidinylpyrimidine/2-chloro-4,6-bis-pyrrolidinylpyrim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22137d8f03383f477675b0f22a8a5e12
https://doi.org/10.1021/op060093q
https://doi.org/10.1021/op060093q
Publikováno v:
The Journal of Organic Chemistry. 71:5646-5657
The first efficient, one-pot method for methylenation of p-toluyl sulfones (i.e., the transformation of p-MePhSO2CHR2 into R2CCH2) is described. Methods for effecting that transformation involving alkylation of sulfones with reagents of the general f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d0ce52b088312b3e83a6b88f92fd32a
https://doi.org/10.1021/jo060669+
https://doi.org/10.1021/jo060669+
Autor:
Thomas J. Thamann, Wayne K. Duholke, Brian D. Kaluzny, Russell H. Robins, Jane E. Guido, Bruce A. Pearlman, Frank W. Crow, Chad E. Hadden, Gary E. Martin
Publikováno v:
Journal of Heterocyclic Chemistry. 36:1107-1114
TipranavirTM (PNU-140690) is a protease inhibitor under clinical investigation for the treatment of human acquired immunodeficiency syndrome (AIDS). During scale-up synthesis of clinical quantities of the bulk drug, a colored, transient by-product of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3a6cd94e9f57f059ddc9d5eaca9726d
https://doi.org/10.1002/jhet.5570360448
https://doi.org/10.1002/jhet.5570360448
Publikováno v:
Organic Letters. 8:2111-2113
[reaction: see text] Whereas ozonization of furan 3a affords little or no carboxylic acid 5, ozonization of the corresponding trans-enedione 6 afforded carboxylic acid 5 in 82.4% yield (cryst., overall from furan, 100 g scale; after workup with dimet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc66a6b5bcdc0bc50e79d31ab3a8d6a9
https://doi.org/10.1021/ol060503v
https://doi.org/10.1021/ol060503v
Publikováno v:
The Journal of organic chemistry. 71(15)
The first efficient, one-pot method for methylenation of p-toluyl sulfones (i.e., the transformation of p-MePhSO2CHR2 into R2CCH2) is described. Methods for effecting that transformation involving alkylation of sulfones with reagents of the general f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1cb61c53b58304f445b16a7cc4bea972
https://pubmed.ncbi.nlm.nih.gov/16839145
https://pubmed.ncbi.nlm.nih.gov/16839145
Publikováno v:
The Journal of organic chemistry. 68(25)
N-Methyl-N-[(1S)-1-[(3R)-pyrrolidin-3-yl]ethyl]amine (1)(1) is a key intermediate in the preparation of premafloxacin (2), which was under development as an antibiotic for use against pathogens of veterinary importance. This paper describes the devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24471d06d81b85c7add83a314a0d3241
https://pubmed.ncbi.nlm.nih.gov/14656085
https://pubmed.ncbi.nlm.nih.gov/14656085
Autor:
David J. C. Constable, Peter J. Dunn, John D. Hayler, Guy R. Humphrey, Johnnie L. Leazer Jr., Russell J. Linderman, Kurt Lorenz, Julie Manley, Bruce A. Pearlman, Andrew Wells, Aleksey Zaks, Tony Y. Zhang
Publikováno v:
Green Chemistry; May2007, Vol. 9 Issue 5, p411-420, 10p
Autor:
Bruce A. Pearlman
Publikováno v:
Journal of the American Chemical Society. 101:6398-6404
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0a933117b46118c95fba614380609d8
https://doi.org/10.1021/ja00515a039
https://doi.org/10.1021/ja00515a039